Cytomorphology of Crystal Storing Histiocytosis in the Breast Associated with Lymphoma: A Case Report

Abstract

Crystal storing histiocytosis (CSH) is a very rare immunoglobulin (Ig) deposition disorder in which macrophages accumulate light chains or Ig crystalline inclusions. It is frequently associated with lymphoproliferative disorders, but can be seen in some reactive conditions too. This article reports the cytomorphologic, histopathologic, and ancillary study findings of a marginal zone B cell lymphoma of the breast with CSH in a 54-year-old woman. To the best of our knowledge, this is the first report describing CSH in the breast and one of a few reports describing the cytomorphology of CSH. In breast fine-needle aspiration biopsies, CSH can be confused with benign processes such as fat necrosis and histiocytic lesions. Thus, awareness of this rare entity and its frequent association with lymphoproliferative disorders is useful in order to triage a specimen appropriately and exclude the possibility of a lymphoproliferative process.

Localized Crystal-Storing Histiocytosis Presenting as a Breast Nodule: An Unusual Presentation of a Rare Entity

“…Localized solitary extra medullary presentation is extremely rare and is exceptionally rare in breast. Till date, only one case of multifocal breast involvement by CSH has been reported in a patient with past history of marginal zone lymphoma . Our case is unique for the localized presentation in breast with no past history of LP‐PCD.…”