Pulmonary Blastoma: A Case Report and Review of the Literature

Cox, James L.; Fuson, Robert L.; Daly, John T.

doi:10.1016/s0003-4975(10)65521-x

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…The commonest clinical presentation was with cough and haemoptysis (9 out of 13 cases). Three cases had no symptoms and in one, symptoms were due to cerebral metastases (Cox et al, 1970). Preoperatively, diagnosis is difficult.…”

Section: Discussionmentioning

confidence: 95%

“…Pulmonary blastoma is a rare tumour and only 19 cases are reported in the world literature (Cox, Fuson, and Daly, 1970). The commonest clinical presentation was with cough and haemoptysis (9 out of 13 cases).…”

Section: Discussionmentioning

confidence: 99%

“…The longest survival reported after resection is 15 years and the shortest is three months. The average age was 48 years, the range being 19 to 74 years (Cox et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary blastoma: a case report

et al. 1974

Thorax

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. (1974). Thorax, 29,[138][139][140][141]. Pulmonary blastoma. A case report of a pulmonary blastoma is presented. A tumour was suspected at surgery and on histological examination this proved to be a pulmonary blastoma. A short review of the histogenesis and methods of treatment is given.Pulmonary blastoma is the least common of all tumours of the lung. This histological entity was first recognized in 1952. To date only 19 cases have been reported in the literature. There is considerable controversy regarding its histogenesis which has not yet been settled. The purpose of this communication is to present a case of pulmonary blastoma that we recently encountered. CASE REPORTMrs. K., a 30-year-old woman, was admitted to hospital on account of pain in the posterior part of the right lower chest of 30 days' duration. The pain was episodic, radiating down the intercostal spaces and not aggravated by cough or respiratory excursions. She was afebrile and had no cough. There was no weight loss. Her physician had diagnosed a loculated effusion in the right chest from the radiograph. Two attempts at thoracentesis were made. It was reported that clear fluid was aspirated but this was not definitely documented. Before the onset of this illness she was in good health.At the time of admission her general condition was satisfactory. There was no clubbing. The trachea was central and there was no mediastinal shift. The percussion note was impaired and vocal fremitus and resonance were decreased markedly at the right base. The breath sounds were decreased on the posterior aspect of the lower part of the right hemiithorax. Other systems were normal. The white cell count was 8,500/mm3, with 72-0% neutrophils, 8-0% eosinophils, and 20-0% lymphocytes. The erythrocyte sedimentation rate was not raised. Casoni's test was negative. The chest radiograph (Fig. 1) showed a large, homogeneous, well-defined mass in the region of the right lower lobe. The (Fig. 3)

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Pulmonary blastoma: a case report

et al. 1974

Thorax

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“…There were three intraoperative deaths [ 1 I , 14, 381. Three patients died postoperatively; one of "cachexia" at three months [9], one sudden death at four months [ 1 11, and one of a pyopneumothorax following bronchial stump breakdown five months after surgery [2]. Two patients had incomplete surgical resections [ 15, 291. Of the remaining 38 patients, 16 are alive and without evidence of disease at the reported time of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy of pulmonary blastoma: A case report and review of the literature

Kummet

Doll

1982

Med. Pediatr. Oncol.

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“…She survived a total of 11 years after her initial resection but eventually died from complications of metastatic disease [19]. Cox et al employed an adjuvant radiation therapy, which the patient tolerated well and continued to have no evidence of disease [20].…”

Section: Reviewmentioning

confidence: 99%

Cure of Oligometastatic Classic Biphasic Pulmonary Blastoma Using Aggressive Tri-modality Treatment: Case Series and Review of the Literature

Lewis

Petty

Urbanic

et al. 2018

Cureus

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Pulmonary blastoma is a rare lung cancer classified into three subtypes: classic biphasic pulmonary blastoma (CBPB), well-differentiated fetal adenocarcinoma (WDFA), and pleuropulmonary blastoma (PPB) of childhood. Compared to the other subtypes, CPPB is an aggressive tumor with an overall five-year survival of 16% across all stages. We present two cases of biopsy-proven metastatic CBPB, who have been disease-free for over 10 years since treatment completion. Both patients were treated with surgery to the primary tumor followed by an adjuvant cisplatin-based chemotherapy for four cycles and thoracic radiation. One patient relapsed shortly after the completion of thoracic radiation with brain metastases and underwent craniotomy, gamma knife radiosurgery (GKRS), and whole brain radiation therapy. The other patient presented with synchronous pelvic metastases and underwent metastasectomy after the completion of chemotherapy but before the initiation of thoracic radiation. We review the literature regarding surgical, chemotherapeutic, and radiation treatment for patients with metastatic pulmonary blastoma. Based on our experience and review of the existing case reports, aggressive tri-modality treatment including surgery, chemotherapy with a cisplatin backbone, and a definitive treatment of oligometastatic lesions amenable to local therapy including resection or radiosurgery is reasonable to consider for medically fit patients with CBPB.

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Pulmonary Blastoma: A Case Report and Review of the Literature

Cited by 8 publications

References 9 publications

Pulmonary blastoma: a case report

Pulmonary blastoma: a case report

Chemotherapy of pulmonary blastoma: A case report and review of the literature

Cure of Oligometastatic Classic Biphasic Pulmonary Blastoma Using Aggressive Tri-modality Treatment: Case Series and Review of the Literature

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