Chemotherapy of pulmonary blastoma: A case report and review of the literature

Kummet, Thomas; Doll, Donald C.

doi:10.1002/mpo.2950100106

Cited by 14 publications

(4 citation statements)

References 32 publications

(4 reference statements)

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“…In the first case, the prognosis was worse because the tumor was huge on presentation and patient had delay of starting chemotherapy. Unfortunately, she couldn't receive complete chemotherapy regimen or radiotherapy [6].…”

Section: Discussionmentioning

confidence: 99%

Pleuropulmonary blastoma is a rare malignancy in young adult and childhood

Zareifar

Karimi

Tasbihi

et al. 2015

Korean J Clin Oncol

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Case 1 A 3.5-year-old girl presented with 3 week history of shortness of breath, non-productive cough, fever and right-sided non-pleuritic chest pain. She was taken two courses of oral antibiotics but without any improvement. She was previously fit and well without history of exposure to second hand smoking. Initial investigations showed normal complete blood counts, liver and kidney function tests. Serum electrolytes and urine analysis were also normal. Chest radiography revealed complete opacification of the right hemithorax, contralateral mediastinal shifting consistent with right sided large pleural effusion (Fig. 1). Contrast enhanced chest computed tomography scan (CT scan) confirmed large right pleural effusion with associated mediastinal shift and complete right lung collapse. No abnormality was reported in the left hemithorax or upper abdomen. Right thoracotomy and decortication revealed large un-resectable masses with adherent deposits on the diaphragm and enlarged pericardial lymph nodes. The right middle lobe was obliterated. Multiple biopsies were taken from tumor and lymph nodes. Pleural fluid analysis demonstrated an exudative pattern. Bone marrow aspiration and biopsy were normal.Due to her critical condition with suspicion of primitive neuroec-

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Section: Discussionmentioning

confidence: 99%

Pleuropulmonary blastoma is a rare malignancy in young adult and childhood

Zareifar

Karimi

Tasbihi

et al. 2015

Korean J Clin Oncol

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“…In 1982, Kummet et al presented a chemotherapeutic regimen that achieved a partial response in an adult patient with a metastatic pulmonary blastoma [36]. The patient was a 31-year-old female who presented with a cough and was found to have a large right upper lobe mass.…”

Section: Reviewmentioning

confidence: 99%

“…She eventually developed local recurrence and died seven months from the initiation of chemotherapy. The authors conclude that patients with large primary tumors (> 5 cm) may benefit from a combination of surgery and chemotherapy [36].…”

Section: Reviewmentioning

confidence: 99%

Cure of Oligometastatic Classic Biphasic Pulmonary Blastoma Using Aggressive Tri-modality Treatment: Case Series and Review of the Literature

Lewis

Petty

Urbanic

et al. 2018

Cureus

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Pulmonary blastoma is a rare lung cancer classified into three subtypes: classic biphasic pulmonary blastoma (CBPB), well-differentiated fetal adenocarcinoma (WDFA), and pleuropulmonary blastoma (PPB) of childhood. Compared to the other subtypes, CPPB is an aggressive tumor with an overall five-year survival of 16% across all stages. We present two cases of biopsy-proven metastatic CBPB, who have been disease-free for over 10 years since treatment completion. Both patients were treated with surgery to the primary tumor followed by an adjuvant cisplatin-based chemotherapy for four cycles and thoracic radiation. One patient relapsed shortly after the completion of thoracic radiation with brain metastases and underwent craniotomy, gamma knife radiosurgery (GKRS), and whole brain radiation therapy. The other patient presented with synchronous pelvic metastases and underwent metastasectomy after the completion of chemotherapy but before the initiation of thoracic radiation. We review the literature regarding surgical, chemotherapeutic, and radiation treatment for patients with metastatic pulmonary blastoma. Based on our experience and review of the existing case reports, aggressive tri-modality treatment including surgery, chemotherapy with a cisplatin backbone, and a definitive treatment of oligometastatic lesions amenable to local therapy including resection or radiosurgery is reasonable to consider for medically fit patients with CBPB.

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“…Effective treatment is still a matter of controversy [3]. Surgery, radiation, and chemotherapy all have been utilized for locally recurrent and metastatic pulmonary blastoma.…”

mentioning

confidence: 99%