Pulmonary apoptotic and oxidative damaging effects of Triclosan alone or in combination with Fluoride in Sprague Dawley rats

Mohammed, Amira; Mohamed, Amany Abdel-Rahman; Ali, Haytham

doi:10.1016/j.acthis.2017.03.004

Cited by 24 publications

(14 citation statements)

References 32 publications

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“…The decline in the uterine CaBP‐9k expression following NAF treatment together with the normal thyroid function could be responsible for the former outcome. Similar antagonism between TCS and NAF in the lung tissue was previously reported . They attributed this antagonism to the mechanism through which each chemical induces its apoptotic effect while they were administered together to the animal.…”

Section: Discussionsupporting

confidence: 81%

“…TCS induced various disorders in the lung, skin, and heart . In mammals, TCS could be considered as an endocrine disruptor .…”

Section: Introductionmentioning

confidence: 99%

“…and NaF (50 mg NaF /kg b.wt.) for 30 days have been investigated in the lung of Sprague–Dawley rats . However, the outcomes of TCS and NaF oral coexposure on the endocrine system of the female rat are still unknown.…”

Section: Introductionmentioning

confidence: 99%

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Impact of subchronic exposure to triclosan and/or fluoride on estrogenic activity in immature female rats: The expression pattern of calbindin‐D9k and estrogen receptor α genes

Abd‐Elhakim

Mohammed

Ali

2018

J Biochem & Molecular Tox

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This study explored the influence of triclosan (TCS) in the absence and presence of sodium fluoride (NaF) on estrogenic activity and thyroid function of adolescent female rats. The results indicated that the individual exposure to TCS evoked a significant decline in T and T but the levels of estradiol, FSH, and LH were significantly elevated beside marked up regulation of calbindin-D9k and estrogen α mRNA expression. On the other hand, the single exposure to NaF causes insignificant changes in thyroid hormones, but evoked a trend toward an increase in both estradiol and LH levels. No significant differences in the TSH level were recorded among the experimental groups. The joint exposure to TCS and NaF induced a significant improvement in thyroid and reproductive hormone levels. Overall, these findings revealed that exposure to TCS resulted in significant endocrine and reproductive alterations in immature female rats, while TCS + NaF coexposure resulted in lessening most effects.

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Section: Discussionsupporting

confidence: 81%

“…TCS induced various disorders in the lung, skin, and heart . In mammals, TCS could be considered as an endocrine disruptor .…”

Section: Introductionmentioning

confidence: 99%

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Impact of subchronic exposure to triclosan and/or fluoride on estrogenic activity in immature female rats: The expression pattern of calbindin‐D9k and estrogen receptor α genes

Abd‐Elhakim

Mohammed

Ali

2018

J Biochem & Molecular Tox

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“…Evidence for testicular DNA damage, elevated malondialdehyde (MDA), and superoxide dismutase (SOD), in addition to diminished catalase (CAT), was related to TCS treatment in weanling rats [104]. Similarly, in lung homogenates of female albino rats, TCS was found to induce lipid peroxidation and severely deplete the levels of other crucial antioxidants: SOD, CAT, and glutathione (GSH) [105]. Increased expression of glutathione peroxidase 1 ( Gpx1 ) and aldehyde oxidase 1 ( Aox1 ) was also observed as a consequence to TCS exposure in C57BL/6 mice [106].…”

Section: Oxidative Stressmentioning

confidence: 99%

Triclosan: An Update on Biochemical and Molecular Mechanisms

Alfhili

Lee

2019

Oxidative Medicine and Cellular Longevity

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Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in commercial and healthcare products. Items made with TCS include soaps, deodorants, shampoos, cosmetics, textiles, plastics, surgical sutures, and prosthetics. A wealth of information obtained from in vitro and in vivo studies has demonstrated the therapeutic effects of TCS, particularly against inflammatory skin conditions. Nevertheless, extensive investigations on the molecular aspects of TCS action have identified numerous adversaries associated with the disinfectant including oxidative injury and influence of physiological lifespan and longevity. This review presents a summary of the biochemical alterations pertaining to TCS exposure, with special emphasis on the diverse molecular pathways responsive to TCS that have been elucidated during the present decade.

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“…The results of the immunohistochemical staining were evaluated using light microscopy, as was described previously [ 14 ]. Briefly, the quantitative analysis of MAO-B in kidney cancer tissues was performed using ImageJ software accompanied by IHC profiler plugin developed by Varghese et al [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Monoamine Oxidase B in Renal Cell Carcinoma

et al. 2018

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BackgroundStudies on monoamine oxidase B (MAO-B) expression in renal cell carcinoma (RCC) are lacking. This study focused on the immunohistochemical evaluation of MAO-B in RCC.Material/MethodsSixty-three RCC samples were compared on basic clinical and histopathological parameters, including histopathological type and tumor grade. RCC samples were divided according to the histopathological type into 2 groups: conventional type (51 samples) and other types (12 samples). For MAO-B detection, a standard immunohistochemical procedure was employed.ResultsIn healthy kidney samples, MAO-B was detected predominantly in tubules. Fifty-two cancer tissue samples were MAO-B negative and 11 tissue samples were MAO-B low positive. Enzymes were detected only in the cytoplasm. We did not find any significant correlation between the percentage of positive MAO-B specimens and nuclear grade. Additionally, Fisher’s test did not reveal any difference in numbers of positive and negative MAO-B samples between the 2 RCC types (P>0.05).ConclusionsFrom our results, it was clear that MAO-B expression played no significant role in stimulation of renal cancer development. We found that MAO-B occurred only in 19% of kidney tumors and that the positivity of protein expression was low. Moreover, it seems that the disappearance of this enzyme in RCC is a consequence of replacement of healthy tissue by cancer cells. On the other hand, one can assume that the loss of MAO-B expression could be associated with severe pathological processes in the kidney.

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Pulmonary apoptotic and oxidative damaging effects of Triclosan alone or in combination with Fluoride in Sprague Dawley rats

Cited by 24 publications

References 32 publications

Impact of subchronic exposure to triclosan and/or fluoride on estrogenic activity in immature female rats: The expression pattern of calbindin‐D9k and estrogen receptor α genes

Impact of subchronic exposure to triclosan and/or fluoride on estrogenic activity in immature female rats: The expression pattern of calbindin‐D9k and estrogen receptor α genes

Triclosan: An Update on Biochemical and Molecular Mechanisms

Monoamine Oxidase B in Renal Cell Carcinoma

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