Pullulan-based nanomaterials in drug delivery applications

Rajalekshmy, G. P.; Mariya, Rajan Annie; Rekha, M.R.

doi:10.1016/b978-0-12-820874-8.00010-5

Cited by 4 publications

(7 citation statements)

References 60 publications

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“…The NPs exhibited much lower IC50 value against HepG2 cells in comparion to free components of nanomaterial. Biodistribution analysis confirmed that elevated degree of Au was internalized in cells as compared to other organs, suggesting that pullulan stabilized AuNPs are suitable for targeted delivery [128]. Fullerene (C60)-pullulan conjugates act as photodynamic antitumor therapeutics exhibited a higher affinity with the asialoglycoprotein receptors to target HepG2 cells [129].…”

Section: Paclitaxel (Ptx)-loaded Chitosan Nanoparticles (Nps) Modifie...mentioning

confidence: 84%

Microbial polysaccharides: An emerging family of natural biomaterials for cancer therapy and diagnostics

Prateeksha

Sharma

Liu

et al. 2022

Seminars in Cancer Biology

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Section: Paclitaxel (Ptx)-loaded Chitosan Nanoparticles (Nps) Modifie...mentioning

confidence: 84%

Microbial polysaccharides: An emerging family of natural biomaterials for cancer therapy and diagnostics

Prateeksha

Sharma

Liu

et al. 2022

Seminars in Cancer Biology

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“…Integrin-mediated cell adhesion can lead to cell internalization of different pullulan forms. 40 2.7. Xanthan.…”

Section: Levanmentioning

confidence: 99%

“…For efficient bioactive compound delivery, pullulan can be transformed into multiple forms, including nanospheres, nanogels, and nanoparticles. Integrin-mediated cell adhesion can lead to cell internalization of different pullulan forms …”

Section: Microbial Polysaccharidesmentioning

confidence: 99%

“…Pullulan is extensively used in food, biomedical, and pharmacological industries due to its numerous properties, such as high solubility, structural flexibility, thickening, and encapsulation ability. With the incidence of several reactive hydroxyl groups, pullulan is a versatile polymer that can be altered with various conjugation techniques to introduce additional functional groups or to conjugate with different bioactive compounds . For efficient bioactive compound delivery, pullulan can be transformed into multiple forms, including nanospheres, nanogels, and nanoparticles.…”

Section: Microbial Polysaccharidesmentioning

confidence: 99%

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Microbial Polysaccharide-Based Nanoformulations for Nutraceutical Delivery

Srivastava

Choudhury

2022

ACS Omega

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In recent times, nutrition and diet have become prominent health paradigms due to sedentary lifestyle disorders. Preventive health care strategies are becoming increasingly popular instead of treating and managing diseases. A nutraceutical is an innovative concept that offers additional health benefits beyond its fundamental nutritional value. These nutraceuticals have the potential to reduce the exorbitant use of synthetic drugs because the modern medicine approach of treating diseases with high-tech, expensive supplements, and long-term consequences aggravates consumers. However, most nutraceuticals are plant-derived, making them susceptible to degradation and prone to chemical instability, poor solubility, unpleasant taste, and bioactivity loss before absorption to the targeted site. To counteract this problem, the bioavailability of these labile compounds can be maximized by encapsulating them in protective nanocarriers. It is crucial that nanoencapsulation technologies convert bioactive compounds into forms that can be easily combined with functional foods and beverages without adversely affecting their organoleptic properties. In recent years, nanoformulations using food-grade materials, such as polysaccharides, proteins, lipids, etc., have received considerable attention. Among them, microbial polysaccharides are biocompatible, nontoxic, and nonimmunogenic, and most of them are US-FDA approved and can undergo tailored modifications. The nanoformulation of microbial polysaccharide is a relatively new frontier which has several advantages over existing systems. The present article, for the first time, comprehensively reviews microbial polysaccharides-based nanodelivery systems for nutraceuticals and discusses various techno-commercial aspects of these nanotechnological preparations. Moreover, this has also attempted to draw a future research perspective in this area.

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“…Pullulan is another FDA-approved polysaccharide of interest for bio-nanomedicine. It is non-toxic, non-mutagenic, non-immunogenic, and non-carcinogenic; thus, pullulanbased nanoparticles have important scientific value, receiving great research interest in designing excellent vaccine delivery systems [6,[75][76][77]. In addition, pH-sensitive pullulanbased nanocarriers can be employed in anti-angiogenesis and chemotherapy against hepatocellular carcinoma, acting as targeted carriers of genes or proteins without presenting cytotoxic effects to normal cells [75].…”

Section: Pullulanmentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

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Pullulan-based nanomaterials in drug delivery applications

Cited by 4 publications

References 60 publications

Microbial polysaccharides: An emerging family of natural biomaterials for cancer therapy and diagnostics

Microbial polysaccharides: An emerging family of natural biomaterials for cancer therapy and diagnostics

Microbial Polysaccharide-Based Nanoformulations for Nutraceutical Delivery

Polymer-Based Nanosystems—A Versatile Delivery Approach

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