Microbial polysaccharides: An emerging family of natural biomaterials for cancer therapy and diagnostics

Prateeksha,; Sharma, Vivek; Liu, Xiaowen; Oyarzún, Diego A.; Abdel-Azeem, Ahmed M.; Atanasov, Atanas G.; Hesham, Abd El-Latif; Barik, Saroj Kanta; Gupta, Vijai Kumar; Singh, Brahma N.

doi:10.1016/j.semcancer.2021.05.021

Cited by 20 publications

(10 citation statements)

References 287 publications

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“…Chitosan-based therapeutic agents have been demonstrated to enhance the efficacy of conventional anti-cancer treatment strategies (Prateeksha et al, 2021). For instance, chitosan nanoparticles have been shown to enhance the radiosensitivity of breast tumors in mice models (Castro et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Iron Oxide Nanoparticles Synthesized from Chitosan Aqueous Extract of Penaeus monodon Shrimp Shells Against Pc-3 Cell Line

Venkadachalam¹,

Indra²,

Sangeetha³

et al. 2022

IJZI

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Magnetic iron oxide nanoparticles (Cs-FeNPs) are increasingly being studied for potential anticancer applications to circumvent off-target cytotoxicity and other side effects from conventional chemotherapy. In this study chitosan aqueous extracts were used as natural stabilizers to synthesize Cs-FeNPs followed by a series of characterization experiments and in vitro anticancer evaluation. Morphological studies demonstrated that adding peel extract decreased the size of NPs with an average particle size below 100 nm. Cytotoxicity assay showed that the Cs-FeNPs were more reactive (IC50 29.759 µg/ml) against PC-3 cancer cell lines and normal Vero cell lines. Specifically, Cs-FeNPs displayed potent anticancer activities against PC-3 cell line. This study showed the characterization of eco-friendly synthesized Cs-FeNPs and their potential use as anticancer therapeutic agents against PC-3 cells.

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Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Iron Oxide Nanoparticles Synthesized from Chitosan Aqueous Extract of Penaeus monodon Shrimp Shells Against Pc-3 Cell Line

Venkadachalam¹,

Indra²,

Sangeetha³

et al. 2022

IJZI

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“…For example, hydrophobic and low molecular weight polysaccharides exhibit less antitumor potential as compared to their counterparts. On the other hand, polysaccharides containing β-(1 → 3) glycosidic bonds in their backbone structure, and β-(1 → 6) branching points, show superior anticancer activities ( 15 ). Before discussing microbial polysaccharides, we first discuss some of the well-known microbial monosaccharides.…”

Section: Types Of Microbial Polysaccharides and Their Applicationsmentioning

confidence: 99%

Bacterial polysaccharides—A big source for prebiotics and therapeutics

Khan

Shah

et al. 2022

Front. Nutr.

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Bacterial polysaccharides are unique due to their higher purity, hydrophilic nature, and a finer three-dimensional fibrous structure. Primarily, these polymers provide protection, support, and energy to the microorganism, however, more recently several auxiliary properties of these biopolymers have been unmasked. Microbial polysaccharides have shown therapeutic abilities against various illnesses, augmented the healing abilities of the herbal and Western medicines, improved overall health of the host, and have exerted positive impact on the growth of gut dwelling beneficial bacteria. Specifically, the review is discussing the mechanism through which bacterial polysaccharides exert anti-inflammatory, antioxidant, anti-cancer, and anti-microbial properties. In addition, they are holding promising application in the 3D printing. The review is also discussing a perspective about the metagenome-based screening of polysaccharides, their integration with other cutting-edge tools, and synthetic microbiome base intervention of polysaccharides as a strategy for prebiotic intervention. This review has collected interesting information about the bacterial polysaccharides from Google Scholar, PubMed, Scopus, and Web of Science databases. Up to our knowledge, this is the first of its kind review article that is summarizing therapeutic, prebiotics, and commercial application of bacterial polysaccharides.

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“…From what was described above, it can be seen that deeper and accurate identifying the conformational features of sanghuang polysaccharides contributes helpfully to probe their biological and functional activities, even in designing biomaterials for clinic therapy and vaccines (Zafar et al, 2016 ; Makvandi et al, 2020 ; Alturki, 2021 ; Prateeksha et al, 2021 ). There have been many powerful techniques applied in explaining the architecture of an individual polysaccharide, including the Congo Red test, SEC-MALLS-RI, capillary viscometer, AFM, XRD, molecular modeling, circular dichroism, DSC, DLS, etc.…”

Section: Physicochemical and Structural Propertiesmentioning

confidence: 99%

Current advances and potential trends of the polysaccharides derived from medicinal mushrooms sanghuang

Wang

Zhou

et al. 2022

Front. Microbiol.

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For thousands of years, sanghuang is distinctive as a general designation for a group of precious and rare Chinese medicinal mushrooms. Numerous investigations have revealed that polysaccharide is one of the important biological active ingredients of sanghuang with various excellent biological activities, including antioxidant, anti-aging, anti-tumor, immunomodulatory, anti-inflammatory, anti-diabetic, hepatoprotective, and anti-microbial functionalities. For the past two decades, preparation, structural characterization, and reliable bioactivities of the polysaccharides from fruiting bodies, cultured mycelia, and fermentation broth of sanghuang have been arousing extensive interest, and particularly, different strains, sources, and isolation protocols might result in obvious discrepancies in structural features and bioactivities. Therefore, this review summarizes the recent reports on preparation strategies, structural features, bioactivities, and structure-activity relationships of sanghuang polysaccharides, which will enrich the knowledge on the values of natural sanghuang polysaccharides and support their further development and utilization as therapeutic agents, vaccines, and functional foods in tonic and clinical treatment.

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Microbial polysaccharides: An emerging family of natural biomaterials for cancer therapy and diagnostics

Cited by 20 publications

References 287 publications

Anticancer Activity of Iron Oxide Nanoparticles Synthesized from Chitosan Aqueous Extract of Penaeus monodon Shrimp Shells Against Pc-3 Cell Line

Anticancer Activity of Iron Oxide Nanoparticles Synthesized from Chitosan Aqueous Extract of Penaeus monodon Shrimp Shells Against Pc-3 Cell Line

Bacterial polysaccharides—A big source for prebiotics and therapeutics

Current advances and potential trends of the polysaccharides derived from medicinal mushrooms sanghuang

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