PUK22 Comparison of Utility Score and Quality of Life Score in Thai Patient Between Twice and Thrice-Weekly Hemodialysis

Abstract

with pharmacist-managed ESA clinics (nϭ314) and at six sites with usual care only (nϭ167); outpatients were followed for 6 months in 2009. We took a VA perspective with projections over a five-year time horizon; costs and effectiveness values were discounted at 3%/yr. Strategy-specific likelihoods of target range hemoglobin values (10-12 g/dl) were based on study results. Utilities for ND-CKD and ESA-related adverse events and their likelihood were obtained from the literature. ESA costs were based on average monthly epoetin and darbepoetin doses per patient during the study and VA ESA cost data. RESULTS: In the base case analysis, cost and effectiveness were $12,500 and 2.096 quality-adjusted life-years (QALYs) in the pharmacistmanaged ESA clinics and $15,500 and 2.093 QALYs in usual care; ESA clinics dominated usual care. In one-way sensitivity analyses, ESA clinics no longer dominated if their patients' probability of being in the target range fell to 0.54 (base case 0.71) or if the mean cost/month of epoetin or darbepoetin in ESA clinics increased to approximately $360 (base case $211) or $460 (base case $250), respectively. When all parameters were varied simultaneously in a probabilistic sensitivity analysis, ESA clinics were favored Ն80% of the time regardless of willingness-to-pay threshold. CONCLUSIONS: Pharmacist-managed ESA clinics were less costly and more effective than usual care in patients receiving ESAs for anemia and ND-CKD. Results were robust to variation and support the use of pharmacist-managed ESA clinics.

Kidney Disease–Specific Scores and Health Utility of Continuous Ambulatory Peritoneal Dialysis and Automated Peritoneal Dialysis Patients and Their Caregivers

“…The disease-specific questionnaires include the Kidney Disease Quality of Life 36-Item Short-Form Survey (KDQOL-36), the Kidney Disease Quality of Life Short Form Version 1.3, and the Thai Health Related Quality of Life Dialysis. 11,14,[18][19][20][21] Most HRQOL studies on dialysis patients have used KDQOL-36 measurements to evaluate the impact of dialysis on quality of life. 11,20,[22][23][24][25][26][27][28][29] As for the general questionnaires, the EQ-5D can be used to compute a utility score, which is the recommended utility tool for economic evaluations in Thailand.…”

“…11,14,[18][19][20][21] Most HRQOL studies on dialysis patients have used KDQOL-36 measurements to evaluate the impact of dialysis on quality of life. 11,20,[22][23][24][25][26][27][28][29] As for the general questionnaires, the EQ-5D can be used to compute a utility score, which is the recommended utility tool for economic evaluations in Thailand. 30 The present study assessed the HRQOL scores of PD patients by using the KDQOL-36, the EuroQol 5-dimension 5-level questionnaire (EQ-5D-5L), and the visual analogue scale (VAS).…”

Assessment of quality of life determinants in hemodialysis patients of a developing country: A cross-sectional study during ongoing COVID-19 pandemic

“…[ 30 ] Abundant studies conducted regarding frequency of twice or thrice sessions a week in sufferers of CKD reported age range of 50–60 years in maximum individuals. [ 8 , 30 – 33 ] No gender discrimination was observed in encountering CKD among both genders, while in terms of sessions of dialysis, increased frequency of twice-weekly dialysis was detected among females. [ 8 , 30 – 33 ] Significant frequency of thrice-weekly dialysis was reported in males.…”

“…[8] Maximum population of United States of America (USA), Europe, and Japan undergo a traditional thrice weekly course of dialysis while patients of Thailand undergo twiceweekly course of dialysis due to economic restrictions, curtail the decline of QoL. [8] A thrice-weekly plan of dialysis ensures the prolong duration of treatment and higher Kt/V were associated with decline in rate of mortalities due to adequate dialysis. [8] Hemodialysis patients from Taiwan showed lower scores of QoL when compared with patients undergoing peritoneal dialysis.…”

“…[ 8 ] A thrice-weekly plan of dialysis ensures the prolong duration of treatment and higher Kt/V were associated with decline in rate of mortalities due to adequate dialysis. [ 8 ]…”