Publisher Correction: Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning

Weider, Matthias; Starost, Laura; Groll, Katharina; Küspert, Melanie; Sock, Elisabeth; Wedel, Miriam; Fröb, Franziska; Schmitt, Christian; Baroti, Tina; Hartwig, Anna C.; Hillgärtner, Simone; Piefke, Sandra; Fadler, Tanja; Ehrlich, Marc; Ehlert, Corinna; Stehling, Martin; Albrecht, Stefanie; Jabali, Ammar; Schöler, Hans R.; Winkler, Jürgen

doi:10.1038/s41467-018-03871-z

Cited by 8 publications

(1 citation statement)

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“…Some people have done a postmortem pathological study on suicidal patients with severe depression, they found that oligodendrocyte density and the expression of oligodendrocyte function related genes are reduced for these patients, and they drew a conclusion for that patients with severe depression put up severe white matter demyelination (59)(60)(61). There are evidences that olig2 can promote the differentiation of oligodendrocyte progenitor cell (OPC) into myelin oligodendrocytes (62)(63)(64). And LINGO-1 is a negative regulator of myelin formation of oligodendrocytes in the central nervous system (65,66).…”

Section: Exosomes Are Expected To Be a Nano-therapeutic Agent For Depmentioning

confidence: 99%

The Progress in Diagnosis and Treatment of Exosomes and MicroRNAs on Epileptic Comorbidity Depression

et al. 2020

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The occurrence of epilepsy can increase the incidence of depression, and the risk of epilepsy in the patients with depression is also high, both of which have an adverse effect on the life and the psychology of the patient, which is not conducive to the prognosis of the patients with epilepsy. With lucubrating the function of exosomes and microRNAs, some scholars found that the exosomes and its microRNAs have development prospect in the diagnosis and treatment of the disease. MicroRNAs are involved in the regulation of seizures and depression, as biomarkers, that can significantly improve the management of epileptic patients and play a preventive role in the occurrence of epilepsy and epilepsy depressive disorder. Moreover, due to its regulation to genes, appropriate application of microRNAs may have therapeutic effect on epilepsy and depression with the characteristics of long distance transmission and stability of exosomes, to a certain extent. This provides a great convenience for the diagnosis and treatment of epileptic comorbidity depression.

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Section: Exosomes Are Expected To Be a Nano-therapeutic Agent For Depmentioning

confidence: 99%

The Progress in Diagnosis and Treatment of Exosomes and MicroRNAs on Epileptic Comorbidity Depression

et al. 2020

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Quantitative analysis of transcription start site selection inSaccharomyces cerevisiaereveals control by DNA sequence, RNA Polymerase II activity, and NTP levels

Zhu¹,

Vvedenskaya

Nickels

et al. 2021

Preprint

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DNA sequence at Transcription Start Sites (TSSs) is a key determinant of initiation by RNA Polymerase II (Pol II). To function as a TSS, an initiation compatible sequence must be specified by a promoter in an appropriate chromatin context. We report the development of a method for quantitative analysis of transcription initiation by Pol II that involves construction of DNA libraries of barcoded promoter variants, production of RNA transcripts, and analysis of transcript 5’ ends and transcript yields (Pol II MAssively Systematic Transcript End Readout, “Pol II MASTER”). Using Pol II MASTER, we measure the efficiency of transcription initiation during “promoter scanning” by Saccharomyces cerevisiae Pol II for ~1 million unique TSS sequences. Furthermore, we employ Pol II MASTER to determine how Pol II activity, known to widely alter TSS selection in vivo, alters TSS efficiencies across our promoter variants. Pol II MASTER recapitulates known critical qualities of Saccharomyces cerevisiae TSS −8, −1, and +1 positions while demonstrating that surrounding sequences modulate initiation efficiency over a wide range. We discover functional interactions between neighboring sequence positions, indicating that adjacent positions likely function together. We demonstrate that initiation efficiencies are altered for +1 A TSSs relative to +1 G TSSs when Pol II activity is perturbed through genetic means. Pol II MASTER provides data for predictive models of TSS initiation efficiency at genomic promoters.

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Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

Wang

Malik

Suh

et al. 2022

Preprint

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Glioblastoma (GBM) is an aggressive malignant disorder with high recurrence rates and poor survival. Here, we aimed to simultaneously inhibit two aberrant oncomiRs miR 21 and miR 10b which have been previously associated with GBM invasiveness and progression. We synthesized short, gamma-modified peptide nucleic acids (sgPNA) targeted to the miR seed regions and loaded the sgPNAs into bioadhesive nanoparticles (BNPs). When the sgPNA BNPs were added to cultured tumor cells, we observed significant reduction of target oncomiRs and increase of apoptosis in vitro. When delivered in vivo by convection enhanced delivery, sgPNA BNPs dramatically increased the survival in two orthotopic (intracranial) mouse models of GBM. Moreover, the combination of sgPNA BNPs with temozolomide (TMZ) increased the survival of mice with GBM beyond the planned endpoint (120 days) with significant improvements in histopathology. The proposed strategy of sgPNA BNP with TMZ provides an alternative, promising approach for treatment of GBM.

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Publisher Correction: Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning

Abstract: The originally published version of this Article omitted Tanja Kuhlmann and Michael Wegner as jointly supervising authors. This has now been corrected in both the PDF and HTML versions of the Article.

Cited by 8 publications

References 0 publications

The Progress in Diagnosis and Treatment of Exosomes and MicroRNAs on Epileptic Comorbidity Depression

The Progress in Diagnosis and Treatment of Exosomes and MicroRNAs on Epileptic Comorbidity Depression

Quantitative analysis of transcription start site selection inSaccharomyces cerevisiaereveals control by DNA sequence, RNA Polymerase II activity, and NTP levels

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

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