Psychological States and Lymphocyte β-Adrenergic Receptor Responsiveness

Yu, Bum-Hee; Dimsdale, Joel E.; Mills, Paul J.

doi:10.1016/s0893-133x(98)00133-x

Cited by 33 publications

(22 citation statements)

References 28 publications

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“…A decreased ionotropic responsiveness in overcommitment would be congruent with the conclusions of previous studies showing chronic psychological stress (52) or personality characteristics like anxiety, depression (53,54), and hostility (55) to be associated with lower ␤-adrenergic receptor responsiveness. The mechanism that could explain all these findings is decreased responsivity of ␤-receptors by the effect of chronic exposure to catecholamines.…”

Section: Discussionsupporting

confidence: 90%

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Vrijkotte

Doornen

Geus

2004

Psychosomatic Medicine

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Objective: Work stress is associated with an increased risk for cardiovascular disease (CVD). Exaggerated cardiovascular reactivity to work-related stressors or incomplete recovery after work is a proposed mechanism underlying this increase in risk. This study examined the effects of work stress on 24-hour profiles of the pre-ejection period (PEP), a measure of cardiac sympathetic activity, obtained from ambulatory measurement of the impedance cardiogram. Methods: A total of 67 male white-collar workers (age 47.1 Ϯ 5.2) underwent ambulatory monitoring on 2 workdays and 1 non-workday. Work stress was defined according to Siegrist's model as 1) a combination of high effort and low reward at work (high imbalance) or 2) an exhaustive work-related coping style (high overcommitment). Results: High overcommitment was associated with shorter absolute PEP levels during all periods on all 3 measurement days, reduced wake-to-sleep PEP differences and reduced PEP variability, as indexed by the SD. Conclusions: Overcommitment to work was associated with an increase in basal sympathetic drive and a reduction in the dynamic range of cardiac sympathetic regulation. Both findings are compatible with the hypothesis that overcommitment induces ␤-receptor down-regulation.

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Section: Discussionsupporting

confidence: 90%

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Vrijkotte

Doornen

Geus

2004

Psychosomatic Medicine

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“…STAI State anxiety and BSI anxiety measures may tap into a combination of these two anxiety constructs and that is why these measures were not associated significantly with either haplotype. Consistent with our findings, it has been reported that increased POMS measures of anxiety, but not STAI Anxiety measures, are highly associated with the down-regulation of ADRB on human lymphocytes (Yu et al, 1999). …”

Section: A Heuristic Model Of Functional Variants Of Adrb2supporting

confidence: 93%

“…For example, the STAI Trait Anxiety scale measures trait or chronic levels of perceived anxiety and based on our model is negatively correlated with the haplotype that produce and maintain high levels of ADRB2 expression (i.e., H2). Anxiety assessed with the POMS scale assesses the level of anxiety experienced in the 'here and now" (Yu et al, 1999), and based on our model, should be dynamically associated with the efficiency of agonist-induced receptor internalization that occurs in response to acutely stressful environmental events (i.e., H3). STAI State anxiety and BSI anxiety measures may tap into a combination of these two anxiety constructs and that is why these measures were not associated significantly with either haplotype.…”

Section: A Heuristic Model Of Functional Variants Of Adrb2mentioning

confidence: 99%

“…Panic disorder, with agoraphobia, is associated with decreased lymphocyte β-adrenergic receptor density and diminished stimulation-evoked cAMP production (Maddock et al, 1993). β-adrenergic desensitization is correlated with the severity of psychomotor agitation seen in depressed patients (Mann et al, 1985) and the density of ADRB2 is negatively correlated with anxiety, depression, and hostility assessed with Profile of Mood States (POMS) questionnaire (Yu et al, 1999). Recent studies have also shown that the stimulation of central ADRB2 produces anti-depressive effects in rodents (Zhang et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Three major haplotypes of the β₂ adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder

Diatchenko¹,

Anderson

Slade

et al. 2006

American J of Med Genetics Pt B

174

127

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Adrenergic receptor β 2 (ADRB2) is a primary target for epinephrine. It plays a critical role in mediating physiological and psychological responses to environmental stressors. Thus, functional genetic variants of ADRB2 will be associated with a complex array of psychological and physiological phenotypes. These genetic variants should also interact with environmental factors such as physical or emotional stress to produce a phenotype vulnerable to pathological states. In this study, we determined whether common genetic variants of ADRB2 contribute to the development of a common chronic pain condition that is associated with increased levels of psychological distress and low blood pressure, factors which are strongly influenced by the adrenergic system. We genotyped 202 female subjects and examined the relationships between three major ADRB2 haplotypes and psychological factors, resting blood pressure, and the risk of developing a chronic musculoskeletal pain condition -Temporomandibular Joint Disorder (TMD). We propose that the first haplotype codes for lower levels of ADRB2 expression, the second haplotype codes for higher ADRB2 expression, and the third haplotype codes for higher receptor expression and rapid agonist-induced internalization. Individuals who carried one haplotype coding for high and one coding for low ADRB2 expression displayed the highest positive psychological traits, had higher levels of resting arterial pressure, and were about 10 times less likely to develop TMD. Thus, our data suggest that either positive or negative imbalances in ADRB2 function increase the vulnerability to chronic pain conditions such as TMD through different etiological pathways that imply the need for tailored treatment options.

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“…Stress, hostility, and tension-anxiety have been shown to be associated with lymphocyte β-adrenergic receptor down-regulation in healthy people [Dimsdale et al, 1994;Mills et al, 1997;Suarez et al, 1997;Yu et al, 1999]. There are limitations, however, to using the lymphocyte β 2 -adrenergic receptor as an index of end-organ β-adrenergic receptor function: the distribution of lymphocyte subsets is influenced by acute and chronic stress and this can undermine the validity of this lymphocyte β 2 -adrenergic receptor model [Mills and Dimsdale, 1993].…”

Section: Introductionmentioning

confidence: 99%

Mood states, sympathetic activity, and in vivo β-adrenergic receptor function in a normal population

Kang

Mills

et al. 2008

Depress. Anxiety

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The purpose of this study was to examine the relationship between mood states and β-adrenergic receptor function in a normal population. We also examined if sympathetic nervous system activity is related to mood states or β-adrenergic receptor function. Sixty-two participants aged 25-50 years were enrolled in this study. Mood states were assessed using the Profile of Mood States (POMS). β-adrenergic receptor function was determined using the chronotropic 25 dose isoproterenol infusion test. Level of sympathetic nervous system activity was estimated from 24-hr urine norepinephrine excretion. Higher tension-anxiety, depression-dejection, and anger-hostility were related to decreased β-adrenergic receptor sensitivity (i.e., higher chronotropic 25 dose values), but tensionanxiety was the only remaining independent predictor of β-adrenergic receptor function after controlling for age, gender, ethnicity, and body mass index (BMI). Urinary norepinephrine excretion was unrelated to either mood states or β-adrenergic receptor function. These findings replicate previous reports that anxiety is related to decreased (i.e., desensitized) β-adrenergic receptor sensitivity, even after controlling for age, gender, ethnicity, and body mass index.

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Psychological States and Lymphocyte β-Adrenergic Receptor Responsiveness

Cited by 33 publications

References 28 publications

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Three major haplotypes of the β₂ adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder

Mood states, sympathetic activity, and in vivo β-adrenergic receptor function in a normal population

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Psychological States and Lymphocyte β-Adrenergic Receptor Responsiveness

Cited by 33 publications

References 28 publications

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Overcommitment to Work Is Associated With Changes in Cardiac Sympathetic Regulation

Three major haplotypes of the β2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder

Mood states, sympathetic activity, and in vivo β-adrenergic receptor function in a normal population

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Three major haplotypes of the β₂ adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder