Mood states, sympathetic activity, and in vivo β-adrenergic receptor function in a normal population

Abstract

The purpose of this study was to examine the relationship between mood states and β-adrenergic receptor function in a normal population. We also examined if sympathetic nervous system activity is related to mood states or β-adrenergic receptor function. Sixty-two participants aged 25-50 years were enrolled in this study. Mood states were assessed using the Profile of Mood States (POMS). β-adrenergic receptor function was determined using the chronotropic 25 dose isoproterenol infusion test. Level of sympathetic nervous system activity was estimated from 24-hr urine norepinephrine excretion. Higher tension-anxiety, depression-dejection, and anger-hostility were related to decreased β-adrenergic receptor sensitivity (i.e., higher chronotropic 25 dose values), but tensionanxiety was the only remaining independent predictor of β-adrenergic receptor function after controlling for age, gender, ethnicity, and body mass index (BMI). Urinary norepinephrine excretion was unrelated to either mood states or β-adrenergic receptor function. These findings replicate previous reports that anxiety is related to decreased (i.e., desensitized) β-adrenergic receptor sensitivity, even after controlling for age, gender, ethnicity, and body mass index.

Symptoms of anxiety and depression are related to cardiovascular responses to active, but not passive, coping tasks

“…37,38 For example, several studies have shown that participants with depression and anxiety have fewer betaadrenergic receptors. 22,23,39 Yu et al found that mood states (tension-anxiety, depression-dejection, and angerhostility) were associated with downregulation of betaadrenergic receptors in individuals without a clinical diagnosis of depression or anxiety. 39 Responses to active coping tasks have been extensively characterized by relatively large increases in CO, indicative of a betaadrenergic mediated pattern of responses via central mechanisms.…”

“…22,23,39 Yu et al found that mood states (tension-anxiety, depression-dejection, and angerhostility) were associated with downregulation of betaadrenergic receptors in individuals without a clinical diagnosis of depression or anxiety. 39 Responses to active coping tasks have been extensively characterized by relatively large increases in CO, indicative of a betaadrenergic mediated pattern of responses via central mechanisms. 40 The present study provides further evidence for the involvement of blunted beta-adrenergic receptor responsiveness in participants with high anxiety and depression scores, as these participants showed a smaller magnitude of CO response (a marker of betaadrenergic responsiveness) to the active coping task.…”

Habitual total water intake and dimensions of mood in healthy young women

“…However, two theoretical mechanisms have been advanced. The first involves an association between negative mood state and β-adrenergic receptors (Yu, Kang, Ziegler, Mills, & Dimsdale, 2008), the target receptors of catecholamines. Water deprivation (graded and chronic) elicits an amplification of the sympathetic nervous system (Antunes, Yao, Pickering, Murphy, & Paton, 2006;Colombari et al, 2011, respectively), which may in turn induce negative mood states via reduced sensitization of β-adrenergic receptors.…”

Gating of hippocampal output by β-adrenergic receptor activation in the pilocarpine model of epilepsy

“…Experimental models and studies in humans suggest that seizures go along with disturbances in the adrenergic system (Trottier et al, 1981;Yu et al, 2009). Norepinephrine acting via b-adrenergic receptors (b-ARs) plays a central role in memory formation and http://dx.doi.org/10.1016/j.neuroscience.2014.11.055 0306-4522/Ó 2014 IBRO.…”