Psoriasis Increases the Risk of Sudden Sensorineural Hearing Loss: A Longitudinal Follow Up Study Using a National Sample Cohort

Choi, Hyo Geun; Park, Bumjung; Hong, Seok Min; Park, Il‐Seok; Kim, Sung Kyun

doi:10.3390/ijerph17249310

Cited by 4 publications

(18 citation statements)

References 40 publications

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“…Two included population-based studies focused specifically on rates of SSNHL (33,44). Our pooled analysis showed that psoriasis patients had higher rates of SSNHL.…”

Section: Discussionmentioning

confidence: 99%

“…Sudden Sensorineural Hearing Loss Two large population-based studies (33,44) specifically examined sudden sensorineural hearing loss (SSNHL) using medical claims codes or the International Classification of Disease for psoriasis and SSNHL. One study (33) reported that SSNHL was confirmed with audiometry examination. It is unclear if the second study (44) confirmed SSNHL in the same manner.…”

Section: Patient-reported Symptomsmentioning

confidence: 99%

“…One study used the Charlson Comorbidity index, which does not control for each individual disease but instead controls for the number of comorbidities (45). This same study also included patients who used acitretin (an oral retinoid for psoriasis) and topical salicylate (33). Whereas salicylate has known ototoxicity, acitretin has been associated with sudden-onset hypoacusis in only a few published cases (52)(53)(54).…”

Section: Summary Of Key Findingsmentioning

confidence: 99%

“…Individuals with psoriasis were 1.50-fold more likely to report difficulty with hearing compared with controls. Pure-tone hearing thresholds (averaged between 0.5 and 4 kHz) were highest in psoriasis with arthritis (30.7 [19.8] dB), followed by no psoriasis (18.7 [14.5] dB) then psoriasis without arthritis (13.0 [16.9]) (33).…”

Section: Patient-reported Symptomsmentioning

confidence: 99%

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Otologic Manifestations of Psoriasis: A Systematic Review and Meta-Analysis

et al. 2022

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Introduction: Psoriatic skin lesions are often seen in the auricle and external auditory canal, but middle ear and inner ear manifestations are not easily identified. Several studies have indicated hearing loss and vestibular dysfunction with psoriasis, but the extent of association has not been well defined. Methods: A systematic search of PubMed, CINAHL, Scopus, and Cochrane Library was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Included studies described audiometric or vestibular assessment of psoriasis patients. Meta-analysis was represented with odds ratios (ORs) or mean difference (MD) with 95% confidence intervals. Results: A total of 13 studies with 589 psoriasis patients and 617 healthy controls were included. Age did not significantly differ between psoriasis patients (47.1 [12.4] yr) and healthy controls (45.4 [11.2] yr). Psoriasis area and severity index score was 9.9 (8.4), and body surface area scores was 7.9 (14.7). Pure-tone audiometry analysis showed higher mean hearing thresholds in psoriasis patients compared with healthy controls across all frequencies, with the greatest difference at 4000 Hz (MD,; p < 0.00001). Speech reception thresholds were worse with psoriasis (MD,; p < 0.0001). Abnormal stapedial reflex was more common in psoriasis (OR,; p = 0.004). Abnormal vestibular testing was more common in psoriasis for caloric testing (OR,; p < 0.0001). Two additional studies of 41,681 psoriasis patients and 80,273 healthy controls found that psoriasis patients were at higher risk for sudden sensorineural hearing loss (OR,; p < 0.0001). Conclusion:Our study shows that psoriasis is associated with hearing loss and vestibular dysfunction, but clinical significance remains undefined. The trends noted in our study require more investigation, and the pathophysiologic mechanisms need to be defined.

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“…Two included population-based studies focused specifically on rates of SSNHL (33,44). Our pooled analysis showed that psoriasis patients had higher rates of SSNHL.…”

Section: Discussionmentioning

confidence: 99%

Section: Patient-reported Symptomsmentioning

confidence: 99%

Section: Summary Of Key Findingsmentioning

confidence: 99%

Section: Patient-reported Symptomsmentioning

confidence: 99%

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Otologic Manifestations of Psoriasis: A Systematic Review and Meta-Analysis

et al. 2022

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“…A recent report showed that psoriasis increased the risk of sudden sensorineural hearing loss in a follow-up study in Korea. 2 A clinical study of auditory function showed that hearing loss, mostly of the sensorineural type, was significantly more frequent in psoriasis patients than in controls, and psoriasis was more severe in patients with hearing loss than in those without hearing loss. 3 Psoriasis is a T-helper 17-mediated autoimmune disorder with overproduction of pro-inflammatory cytokines such as tumor necrosis factor (TNF)α. TNFα has been shown to mediate damage to the inner ear, which can result in sensorineural hearing impairment.…”

Section: Generalized Pustular Psoriasis With Deficiency Of Interleukin-36 Receptor Antagonist Associated With Sensorineural Hearing Impaimentioning

confidence: 99%

Generalized pustular psoriasis with deficiency of interleukin‐36 receptor antagonist associated with sensorineural hearing impairment

Ichiyama

Sugiura

Hoashi

et al. 2021

The Journal of Dermatology

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Risk Factors for the Development of Bilateral Ménière's Disease

Phillips,

Murdin,

Grant

et al. 2023

Otol Neurotol

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Objective To identify key risk factors for the development of bilateral Ménière's disease. Study Designs Observational study. Setting Four NHS Trusts and four independent hospitals or clinics, within three distinct urban and rural regions within the United Kingdom (Norfolk, Leicestershire, and London). Methods Patients with Ménière's disease were identified at ENT or audiovestibular medicine secondary/tertiary care and specialist private clinics. A range of patient-reported data, questionnaire data, and clinical data (audiometric, radiological, and specialist balance testing data) was inputted into a bespoke database. A logistic regression model was used to identify potential risk factors for bilateral Ménière's disease compared with unilateral Ménière's disease. Results A total of 411 participants were recruited into this study, 263 from NHS Trusts and 148 from independent hospitals or clinics. In our cohort of patients, 22% of individuals were identified as having bilateral Ménière's disease. Two statistically significant independent variables were identified as risk factors for the development of bilateral Ménière's disease: the presence of psoriasis and a history of ear infections. Conclusions Psoriasis and a history of ear infection have been identified as key risk factors for the development of bilateral Ménière's disease. It is anticipated that further work based on this finding will allow a better understanding of the underlying pathophysiological mechanisms that predispose to the development of Ménière's disease symptoms.

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Psoriasis Increases the Risk of Sudden Sensorineural Hearing Loss: A Longitudinal Follow Up Study Using a National Sample Cohort

Cited by 4 publications

References 40 publications

Otologic Manifestations of Psoriasis: A Systematic Review and Meta-Analysis

Otologic Manifestations of Psoriasis: A Systematic Review and Meta-Analysis

Generalized pustular psoriasis with deficiency of interleukin‐36 receptor antagonist associated with sensorineural hearing impairment

Risk Factors for the Development of Bilateral Ménière's Disease

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