Psoriasis in the elderly: epidemiological and clinical aspects, and evaluation of patients with very late onset psoriasis

Phan, C.; Sigal, M.-L.; Estève, É.; Réguiai, Z.; Barthélémy, H.; Bénéton, N.; Maccari, F.; Lahfa, M.; Thomas‐Beaulieu, D.; Guyadec, T. Le; Vermersch‐Langlin, A.; Méry‐Bossard, L.; Pallure, V.; Kemula, M.; Labeille, B.; Beauchet, Alain; Mahé, E.; Resopso, Gem

doi:10.1111/jdv.12850

Cited by 56 publications

(77 citation statements)

References 16 publications

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“…We found also that the patients who have an occupation in contact with the public scored significantly higher, probably for the same reasons. Earlier studies also noted the decreasing impact of disease with age . It was confirmed herein.…”

Section: Clinical Data and Comparisons Of Discordant Groupssupporting

confidence: 87%

Characteristics of patients with plaque psoriasis who have discordance between Psoriasis Area Severity Index and dermatology life quality index scores

Bretèque

Beauchet

Quiles‐Tsimaratos

et al. 2016

Acad Dermatol Venereol

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Section: Clinical Data and Comparisons Of Discordant Groupssupporting

confidence: 87%

Characteristics of patients with plaque psoriasis who have discordance between Psoriasis Area Severity Index and dermatology life quality index scores

Bretèque

Beauchet

Quiles‐Tsimaratos

et al. 2016

Acad Dermatol Venereol

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“…A cross-sectional study including 2201 adults with psoriasis in France found that childhood onset of psoriasis was not associated with higher frequencies of large waist circumference, obesity, diabetes, dyslipidemia and hypertension; however, these outcomes were associated with increased age[7]. Another similar study investigating very late onset psoriasis (over age of 70) found that very late onset patients tended to have lower frequencies of obesity, diabetes, hypertension, and dyslipidemia than ‘early’ onset patients[8]. In our study, comorbidity prevalence did not increase or decrease with age as indicated in the previous study of psoriatic patients; this may be due to the inclusion of only moderate to severe patients, as metabolic diseases have been found to be more prevalent among these patients and more highly associated with systemic inflammation, these patients may have different distribution patterns of metabolic comorbidities than general patients.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have examined the association between childhood and very late onset psoriasis and metabolic and cardiovascular comorbidities[7,8]. Age at onset was not found to be an independent risk factor for comorbidities in patients with childhood onset psoriasis.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Nonalcoholic Fatty Liver Disease and Related Metabolic Comorbidities Was Associated with Age at Onset of Moderate to Severe Plaque Psoriasis: A Cross-Sectional Study

Gao

et al. 2017

PLoS ONE

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Nonalcoholic fatty liver disease (NAFLD) has been found to be highly prevalent in psoriatic patients. Adult onset psoriasis could be divided into either early or late onset psoriasis. The associations between NAFLD and related metabolic comorbidities and age at onset of psoriasis have not yet been investigated. Our study was to evaluate the associations between prevalence of NAFLD and related metabolic conditions and early, late, and childhood onset psoriasis. A cross-sectional observational study was conducted on patients with moderate to severe plaque psoriasis. Data on clinical characteristics of NAFLD and related metabolic diseases (diabetes, hypertriglyceridemia, hyperuricemia, and metabolic syndrome) were collected. The prevalence of NAFLD in 439 patients (mean: 51±14 years, range: 18–85 years) was 55.8%. NAFLD was frequently identified in early onset patients (74.2%), and this diagnosis was particularly common in patients currently younger than 40 (85.3%). Diabetes was the least prevalent component of metabolic syndrome in early onset patients with metabolic syndrome but the most often found component in late onset ones. Patients with childhood onset psoriasis had the lowest frequencies of all metabolic comorbidities except hyperuricemia among the three groups. In the multivariate analyses, early onset was independently and positively associated with NAFLD, hypertriglyceridemia and hyperuricemia and independently and negatively associated with diabetes among early and late onset patients. The results suggested prevalence of NAFLD and related metabolic comorbidities was associated with age at onset of moderate to severe plaque psoriasis. Early onset of psoriasis was independently associated with greater odds of NAFLD, hypertriglyceridemia, hyperuricemia and smaller odds of diabetes compared to late onset. Early onset patients have metabolic syndrome mainly related to lipid disorders and abnormal glucose metabolism was not often involved.

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“…Bei etwa jedem dritten Patienten mit klassischer Psoriasis vulgaris treten auch intertriginöse Hautveränderun-gen auf. Bei Kindern und älteren Patienten tritt Psoriasis intertriginös etwas häu-figer auf [7,10]. Bei der Psoriasis inversa besteht eine vornehmliche Beteiligung der Beugeseiten der großen Gelenke (Ellenbeuge, Kniebeuge; [2,9,14]).…”

Section: Epidemiologieunclassified

Psoriasis inversa

Weisenseel

Reich

2015

Hautarzt

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Inverse psoriasis is clinically defined by chronic inflammatory lesions in intertrigineous areas. Colonisation or infection with Candida ssp. or bacteria is common. The disease-related quality of life is significantly reduced especially regarding sexual behavior. After the exclusion of relevant differential diagnoses, therapy should be adapted to the clinical outcome and potential comorbidities. Substances which are efficacious in psoriasis vulgaris are generally efficacious in inverse psoriasis, but have to be used off-label. Controlled clinical studies are only available for topical ascomycin.

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Psoriasis in the elderly: epidemiological and clinical aspects, and evaluation of patients with very late onset psoriasis

Abstract: This study highlights phenotypic features of psoriasis in elderly and in very late onset psoriasis. The management of these fragile patients remains poorly codified and needs further investigation.

Cited by 56 publications

References 16 publications

Characteristics of patients with plaque psoriasis who have discordance between Psoriasis Area Severity Index and dermatology life quality index scores

Characteristics of patients with plaque psoriasis who have discordance between Psoriasis Area Severity Index and dermatology life quality index scores

The Prevalence of Nonalcoholic Fatty Liver Disease and Related Metabolic Comorbidities Was Associated with Age at Onset of Moderate to Severe Plaque Psoriasis: A Cross-Sectional Study

Psoriasis inversa

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