Psoriasis inversa

Abstract

Inverse psoriasis is clinically defined by chronic inflammatory lesions in intertrigineous areas. Colonisation or infection with Candida ssp. or bacteria is common. The disease-related quality of life is significantly reduced especially regarding sexual behavior. After the exclusion of relevant differential diagnoses, therapy should be adapted to the clinical outcome and potential comorbidities. Substances which are efficacious in psoriasis vulgaris are generally efficacious in inverse psoriasis, but have to be used off-label. Controlled clinical studies are only available for topical ascomycin.

<p>Inverse Psoriasis: From Diagnosis to Current Treatment Options</p>

“…Differential diagnosis of IP includes any erythematous rash involving the body folds, generically defined as "intertrigo". 12,13 This may be caused by simple mechanical friction, infectious disorders such as fungal and bacterial infections, and some inflammatory diseases. 14 Diagnosis may be troublesome, especially in case of few/ isolated lesions, and laboratory exams and/or histopathology are often required to reach a definitive diagnosis.…”

Efficacy and Microbiota Modulation Induced by LimpiAL 2.5%, a New Medical Device for the Inverse Psoriasis Treatment

“…A moist and warm milieu of fold sites causes the superficial erosions and maceration of tissues, resulting in intense itching, irritation from sweating, and soreness [ 2 , 8 ]. In addition, since the moist and damaged skin provide all the favorite conditions for microbial growth, the development of bacterial and fungal superinfection is also quite frequent, as well as the microbial proliferation at the body fold itself, could promote the IP onset [ 2 , 6 , 9 , 10 , 11 ]. However, the lack of microbiota studies based on advanced sequencing methods makes it hard to establish the role of some microbes detected at affected sites.…”