Psoriasis as a disease associated with the immune system disorders

Chomiczewska-Skóra, Dorota; Trznadel-Grodzka, Ewa; Rotsztejn, Helena

doi:10.5114/ceji.2013.34370

Cited by 7 publications

(10 citation statements)

References 49 publications

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“…The pathogenesis of psoriasis is complex and depends on many factors, including genetic, neurogenic, hormonal or autoimmune ones [ 1 – 6 ]. Immunological disturbances with predominance of Th1 response and oversynthesis of proinflammatory cytokines especially in combination with genetic predisposition lead to a pathogenic vicious circle with the inception and maintenance of the chronic inflammation and abnormal epidermal proliferation [ 7 ]. In recent years clear links have been established between psoriasis and a number of diseases such as obesity, cardiovascular diseases, diabetes and metabolic syndrome [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…In patients with coronary artery disease, leptin is a new and promising predictive factor of the occurrence of cardiovascular events in the future [ 26 ]. Postulated leptin's impact on coexistence of hypertension with severe obesity may have a more negative impact on the course of psoriasis [ 7 ]. Leptin also exerts an influence on the immune system.…”

Section: Introductionmentioning

confidence: 99%

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Effect of psoriasis activity on serum adiponectin and leptin levels

Baran¹,

Flisiak²,

Jaroszewicz³

et al. 2015

pdia

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IntroductionPsoriasis is an inflammatory and chronic skin disease associated with obesity, cardiovascular diseases, diabetes and metabolic syndrome. Adipokines, as bioactive substances secreted from adipose tissue, are involved in various metabolic diseases.AimTo investigate the association between psoriasis severity and serum adiponectin and leptin levels in patients with psoriasis.Material and methodsSerum fasting adiponectin and leptin levels were examined by an enzyme-linked immunosorbent assay in 49 patients with relapse of plaque-type psoriasis and 16 healthy controls. The results were correlated with the Psoriasis Area and Severity Index (PASI), body mass index (BMI), several inflammatory markers, duration of the disease and present relapse.ResultsSerum adiponectin and leptin levels were significantly decreased in psoriatic patients in comparison to the control group. There were no correlations between the above measures and PASI scores, patients’ age, duration of the disease, present relapse and hospitalization, neither between white blood cells or platelets counts. Serum adiponectin levels significantly correlated with C-reactive protein (CRP) levels. Adiponectin was negatively and leptin positively correlated to BMI at statistical significance. Multivariate analysis demonstrated a significant positive correlation between adiponectin and CRP or PASI concentrations as well as between BMI and leptin concentration.ConclusionsThe data showed that serum adiponectin levels increase and serum leptin levels decrease with psoriasis severity. Leptin might be useful in assessing severity and the risk of complications of psoriasis. Moreover, these results confirmed the relationship between leptin, obesity and psoriasis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of psoriasis activity on serum adiponectin and leptin levels

Baran¹,

Flisiak²,

Jaroszewicz³

et al. 2015

pdia

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“…The etiopathogenesis of psoriasis has not been fully elucidated. Nowadays, psoriasis is perceived as a multifactorial disease of genetic origin, in which complex immunological disorders concerning specific and non-specific defense mechanisms play a key role [ 20 , 21 ]. New treatment possibilities for psoriasis and other inflammatory diseases using biological medicines has given patients the opportunity to achieve remission in severe forms of the disease.…”

Section: Discussionmentioning

confidence: 99%

Biosimilars in dermatology

Mazur¹,

Olek‐Hrab²,

Karczewski³

et al. 2015

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Over the last decade the availability of biological drugs for the treatment of psoriasis vulgaris, psoriatic arthritis and many other inflammatory diseases has revolutionized the treatment of these diseases around the world. Due to the high cost of therapy, the search has started for biosimilars. In dermatology the greatest interest in biosimilar medicines concerns inhibitors of tumor necrosis factor a (TNF-α), for use in the treatment of psoriasis vulgaris and psoriatic arthritis (infliximab, etanercept, adalimumab). The most important element of the safety of biologicals is their immunogenicity. Therefore, when discussing biosimilars, attention needs to be paid to the dangers of their immune activity. In view of the fact that the drugs contain and aggregates, produced by living organisms or cultures of living cells, they cannot be compared in any way to low molecular weight synthetic generics (called generics). Biosimilars are authorized for use in patients and treated as equivalent to the reference medicine only after passing a number of studies and assessments. As it is well known, the development of medicine and pharmacology is extremely intense, and the market in biological medicine is developing much faster than that of all other drugs, which underlines their important role in modern medicine. Currently, the subject of biosimilars is one of the most important challenges and topics of discussion around the world, including pharmacovigilance and legal and economic regulatory standards. It seems inevitable that biosimilar products will be introduced for the treatment of diseases with indications corresponding to the original product on which they are based.

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“…T cells with type 1 cytokine profile [(T helper (Th)1 and cytotoxic (Tc)1 cells)], Th17 and Th22 lymphocytes, regulatory T (Treg) cells, natural killer (NK) and NK T cells, antigen‐presenting cells (dendritic cells, including Langerhans cells), keratinocytes, neutrophils, monocytes and macrophages are among the cells that take part in the formation of psoriatic lesions. Other important factors include growth factors, cytokines, adhesion molecules and chemokines …”

Section: Introductionmentioning

confidence: 99%

“…Other important factors include growth factors, cytokines, adhesion molecules and chemokines. [1][2][3] Chemokines are a superfamily of small secreted proteins that regulate cell traffic in both homeostatic and inflammatory conditions. Two of the most investigated chemokines are monocyte chemoattractant protein (MCP)-1 (also known as chemokine ligand 2; CCL2) and regulated upon activation normal T-cell expressed and secreted (RANTES) (also known as CCL5).…”

Section: Introductionmentioning

confidence: 99%