The -2518 A/G<i>MCP-1</i>and -403 G/A<i>RANTES</i>promoter gene polymorphisms are associated with psoriasis vulgaris

Zabłotna, Monika; Sobjanek, Michał; Purzycka-Bohdan, Dorota; Szczerkowska-Dobosz, Aneta; Nedoszytko, Bogusław; Nowicki, Roman

doi:10.1111/ced.12937

Cited by 10 publications

(11 citation statements)

References 17 publications

(34 reference statements)

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“…Multiple studies have been performed to detect the polymorphisms as an important factor in the development of psoriasis: TNF α gene -238G/A polymorphism [ 27 ] -2518 A/G MCP-1 and -403 G/A RANTES promoter gene polymorphisms [ 28 ], CARD14 rs11652075 polymorphism [ 29 ] and support the genetic hypothesis in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients

Elneam¹,

Al‐Dhubaibi²,

Alrheam³

2018

Open Access Maced J Med Sci

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BACKGROUND:Psoriasis is a chronic, recurrent inflammatory skin disease. It is characterised by autoimmune, environmental factors and complex genetic disorder.AIM:To explore the role of IL-6, IL-8, and ACE I/D polymorphism in the pathogenesis of Psoriasis and investigation of the relationship between ACE polymorphism and occurrence of psoriasis.PATIENTS AND METHODS:In this study, we took 73 psoriasis patients and 47 healthy patients as a control. These two groups subjected to analysis for ACE gene I/D polymorphism by PCR and biochemical methods.RESULTS:The serum levels of ACE, IL-8 and IL-6 were statistically significantly higher in psoriasis patients compared to healthy subjects (P < 0.001). ID and DD polymorphism were more common in psoriasis patients than healthy subjects. Also, D allele was significantly over-represented in patients compared to controls (52.7% Vs 35.1%).CONCLUSION:ACE gene polymorphism might grant susceptibility to develop psoriasis.

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Section: Discussionmentioning

confidence: 99%

Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients

Elneam¹,

Al‐Dhubaibi²,

Alrheam³

2018

Open Access Maced J Med Sci

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“…With genotyping of hundreds of thousands of polymorphisms it led in the last decade to identification of novel genetic risk markers associated with psoriasis. The latest results of genetic analyses including patients with psoriasis from northern Poland have demonstrated the association of the –2518 A/G monocyte chemoattractant protein-1 ( MCP-1 ) and –403 G/A regulated on activation, normal T-cell expressed and secreted ( RANTES ) promoter gene polymorphisms with an increased risk of psoriasis and suggested the influence of polymorphisms in the Toll-like receptor 2 ( TRL2 ) and Toll-like receptor 9 ( TLR9 ) genes on the clinical manifestation of this dermatosis [ 31 , 32 ]. Among different genetic markers identified in the context of psoriasis susceptibility, HLA-C*06 still presents the strongest association with the early-onset type of the disease in Caucasians [ 3 , 7 , 8 , 33 – 35 ].…”

Section: Discussionmentioning

confidence: 99%

ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland

Stawczyk-Macieja

Szczerkowska-Dobosz

Rębała

et al. 2018

pdia

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IntroductionHLA-C*06 is a major psoriasis genetic risk marker. Recent reports have been focused on the role of different polymorphisms within genes involved in the functioning of the epidermal barrier and antigen processing in the pathogenesis of psoriasis. Data on the association between genetic variants of LCE3B_LCE3C, CSTA, ERAP1, ZAP70 and this dermatosis in the population from Eastern Europe are lacking.AimTo compare the association between known genetic risk markers and psoriasis in a cohort of northern Polish patients with psoriasis and healthy controls.Material and methodsBased on previous studies’ results, five susceptibility loci: HLA-C, LCE3C_LCE3B, ERAP1, ZAP70 and CSTA were selected for genotyping in 148 patients with chronic plaque psoriasis and 146 healthy controls. Each patient with this disease was clinically assessed with the Psoriasis Area and Severity Index.ResultsThe study population showed a significant association of psoriasis and a single nucleotide polymorphism in the ERAP1 – rs26653 (p = 3.11 × 10–5) and HLA-C*06 allele (p = 1.02 × 10–11) when compared with the control group. The presence of HLA-C*06 or rs26653 G allele significantly increased the risk of psoriasis by 2.4 times or twice, respectively. Carrying rs26653 C allele considerably decreased the risk of psoriasis by 1.5 times.ConclusionsIn the context of pathogenesis of psoriasis, our findings might give the evidence on disturbances in the proteolytic processing of N-terminal fragments of antigens presented via major histocompatibility complex class I to T cells.

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“…In our data analyses, the polymorphism rs1024611 in MCP1 did not show any association with PV susceptibility in genotype or allele. However, in the study by Zablotna et al, [ 20 ] MCP1 rs1024611 polymorphism was found to be significantly associated with the increased risk of PV in northern Poland. Such difference may result from the distribution difference of the polymorphism, different ethnicity, and sample size.…”

Section: Discussionmentioning

confidence: 92%

The association of genetic variants in chemokine genes with the risk of psoriasis vulgaris in Chinese population

et al. 2017

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This study aimed to investigate the influence of polymorphisms in chemokine genes, including MCP1, CCR2, and CCR5 with psoriasis vulgaris (PV) risk in a Chinese population.The genotyping of studied polymorphisms through polymerase chain reaction (PCR) and sequencing was conducted in 142 PV patients and 147 healthy controls. The genotype distribution of the polymorphisms in the control group was checked to determine whether it conformed to Hardy–Weinberg equilibrium (HWE). The genotype and allele frequencies were compared between PV patients and the healthy controls using Chi-square test. Odds ratio (OR) with 95% confidence interval (95% CI) was calculated to assess the relative risk of PV related to genetic variants.CCR2 rs1799864 polymorphism was associated with significantly elevated risk of PV (AA+AG vs GG: OR = 1.62, 95% CI = 1.02–2.59; A vs G: OR = 1.48, 95% CI = 1.02–2.16). In the meanwhile, CCR5 rs1800024 polymorphism also exhibited significant differences in genotype and allele distribution (P < .05), demonstrating its promoting effect on the risk of PV under heterozygous model (OR = 1.73, 95% CI = 1.06–2.82), dominance model (OR = 1.83, 95% CI = 1.14–2.94), and allele model (OR = 1.68, 95% CI = 1.13–2.48).CCR2 rs1799864 and CCR5 rs1800024 polymorphisms may function as independent risk factors for PV in Chinese population.

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The -2518 A/GMCP-1and -403 G/ARANTESpromoter gene polymorphisms are associated with psoriasis vulgaris

Abstract: The results of our analysis suggest that the -2518 A/G MCP-1 and -403 G/A RANTES promoter gene polymorphisms may be risk factors for psoriasis and may influence its clinical presentation.

Cited by 10 publications

References 17 publications

Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients

Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients

ERAP1 and HLA-C*06 are strongly associated with the risk of psoriasis in the population of northern Poland

The association of genetic variants in chemokine genes with the risk of psoriasis vulgaris in Chinese population

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