Effect of psoriasis activity on serum adiponectin and leptin levels

Baran, Anna; Flisiak, Iwona; Jaroszewicz, Jerzy; Świderska, Magdalena

doi:10.5114/pdia.2014.40960

Cited by 51 publications

(51 citation statements)

References 42 publications

(85 reference statements)

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“…Along these lines, TNF-α plasma concentration negatively and significantly correlated with plasma adiponectin levels, whereas plasma leptin levels were not correlated [57]. Conversely, in another study, both serum adiponectin and leptin levels were significantly decreased in psoriatic patients in comparison with the control group [58]. Other reports detected significantly lower levels of adiponectin and visfatin, and significantly higher levels of vaspin, omentin, chemerin, and resistin in psoriatic patients as compared to the control group [42, [59][60][61][62].…”

mentioning

confidence: 72%

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

Chiricozzi

Raimondo

Lembo

et al. 2016

Expert Review of Clinical Immunology

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Psoriasis is a chronic skin disorder associated with several comorbid conditions. In psoriasis pathogenesis, the role of some cytokines, including TNF-α and IL-17, has been elucidated. Beside their pro-inflammatory activity, they may also affect glucose and lipid metabolism, possibly promoting insulin resistance and obesity. On the other hand, adipose tissue, secreting adipokines such as chemerin, visfatin, leptin, and adiponectin, not only regulates glucose and lipid metabolism, and endothelial cell function regulation, but it may contribute to inflammation. Areas covered: This review provides an updated 'state-of-the-art' about the reciprocal contribution of a small subset of conventional cytokines and adipokines involved in chronic inflammatory pathways, upregulated in both psoriasis and increased adiposity. A systematic search was conducted using the PubMed Medline database for primary articles. Expert commentary: Because psoriasis is associated with increased adiposity, it would be important to define the contribution of chronic skin inflammation to the onset of obesity and vice versa. Clarifying the pathogenic mechanism underlying this association, a therapeutic strategy having favorable effects on both psoriasis and increased adiposity could be identified.

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mentioning

confidence: 72%

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

Chiricozzi

Raimondo

Lembo

et al. 2016

Expert Review of Clinical Immunology

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“…Te ostatnie biorą udział w utrzymaniu homeostazy organizmu, regulacji metabolizmu węglowodanów i tłuszczów, hemostazy, rozwoju insulinooporności, miażdżycy oraz procesów zapalnych i immunologicznych. W licznych badaniach udowodniono rolę różnych adipokin w patogenezie łuszczycy w powiązaniu z chorobami ogólnoustro-jowymi [61][62][63][64].…”

Section: Obesityunclassified

“…The latter take part in maintaining systemic homeostasis, regulation of carbohydrate and lipid metabolism, haemostasis, insulin resistance, atherosclerosis, and inflammatory and immune processes. Numerous studies demonstrated the role of various adipokines in the pathogenesis of psoriasis in association with systemic diseases [61][62][63][64].…”

Section: Obesitymentioning

confidence: 99%

The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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Psoriasis, affecting 2-4% of the world's population, is a chronic recurrent inflammatory skin disease. Its multifactorial aetiopathogenesis consists of, for example, abnormal epidermal proliferation, immune disturbances, and genetic, psychosomatic, environmental and hormonal factors. Psoriasis is also considered to be a systemic disorder closely associated with cardiovascular diseases, atherosclerosis, diabetes mellitus, obesity or metabolic syndrome. Lipids have a variety of biological functions. They participate not only in energy storage and expenditure or the formation of cell membranes, but also in inflammatory and metabolic signalling pathways. Disturbances in their homeostasis lead to the development of immunometabolic disorders, including psoriasis. Based on the available literature, this article presents selected molecular and clinical aspects involved in the multidirectional effect of lipids on psoriasis.streszczenie Łuszczyca, która występuje u 2-4% populacji na świecie, jest przewlekłą i nawrotową chorobą zapalną skóry. Na jej wieloczynnikową etiopatogenezę składają się m.in. nieprawidłowa proliferacja naskórka, zaburzenia immunologiczne, czynniki genetyczne, psychosomatyczne, środowiskowe i hormonalne. Łuszczyca jest również uznawana za schorzenie ogólnoustrojowe, związane z chorobami układu sercowo--naczyniowego, miażdżycą, cukrzycą, otyłością i zespołem metabolicznym. Lipidy pełnią wiele biologicznych funkcji, biorą udział nie tylko w magazynowaniu i wydatkowaniu energii, tworzeniu błon komórko-wych, lecz także w zapalnych i metabolicznych szlakach sygnałowych. Zaburzenia ich homeostazy powodują rozwój schorzeń immunometabolicznych, w tym łuszczycy. W niniejszej pracy przedstawiono na podstawie dostępnego piśmiennictwa wybrane aspekty molekularne i kliniczne wielokierunkowego wpływu lipidów na łuszczycę.

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“…Various adipokines have been examined and previously published studies have reported their potential role in the development of certain diseases, such as diabetes, obesity, metabolic syndrome, systemic sclerosis and also psoriasis (6). Especially leptin, adiponectin, resistin or visfatin have been widely studied in patients with psoriasis and considered as linking this disease with its comorbidities (7)(8)(9)(10). Lipocalins belonging to adipokines have been of interest in various medical fields and psoriasis as well.…”

Section: Introductionmentioning

confidence: 99%