Psoriasis and metabolic disease: epidemiology and pathophysiology

Azfar, Rahat S.; Gelfand, Joel M.

doi:10.1097/bor.0b013e3283031c99

Cited by 252 publications

(287 citation statements)

References 50 publications

Supporting

Mentioning

238

Contrasting

Unclassified

Order By: Relevance

“…This inflammatory cascade is named 'psoriatic march', and psoriasis patients are now considered to be at higher risk of developing metabolic syndrome 11 . Systemic inflammation induced by obesity and metabolic syndrome, in turn, could exacerbate local skin inflammation via blood flow, which may consequently expand psoriasis inflammation 12 . The link between local and systemic inflammation is further supported by recent vast reports focusing on the high percentages of psoriasis patients who have cardiovascular and metabolic comorbidities [12][13][14][15][16][17] .…”

mentioning

confidence: 99%

Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells

et al. 2015

View full text Add to dashboard Cite

Accumulating epidemiologic evidence has revealed that metabolic syndrome is an independent risk factor for psoriasis development and is associated with more severe psoriasis. Adiponectin, primarily recognized as a metabolic mediator of insulin sensitivity, has been newly drawing attention as a mediator of immune responses. Here we demonstrate that adiponectin regulates skin inflammation, especially IL-17-related psoriasiform dermatitis. Mice with adiponectin deficiency show severe psoriasiform skin inflammation with enhanced infiltration of IL-17-producing dermal Vg4 þ gd-T cells. Adiponectin directly acts on murine dermal gd-T cells to suppress IL-17 synthesis via AdipoR1. We furthermore demonstrate here that the adiponectin level of skin tissue as well as subcutaneous fat is decreased in psoriasis patients. IL-17 production from human CD4-or CD8-positive T cells is also suppressed by adiponectin. Our data provide a regulatory role of adiponectin in skin inflammation, which would imply a mechanism underlying the relationship between psoriasis and metabolic disorders.

show abstract

mentioning

confidence: 99%

Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The methanol extract (100 and 200 mg/kg) and isolated flavonoid quercetin (25 and 50 mg/kg) were formulated in the form of a cream, using liquid paraffin (10 mL) and bees wax (3 …”

Section: Extracts Testedmentioning

confidence: 99%

“…It affects the patients physically, mentally and socially [1,2] . In psoriasis, epidermal hyperproliferation, abnormal keratinocyte differentiation, angiogenesis with blood vessel dilatation and excess Th-1 and Th-17 inflammation can be observed [3] . Early and active psoriatic lesions are characterized by intraepidermal penetration of activated polymorphonuclear leukocytes, which causes uncontrolled production of reactive oxygen species (ROS), leading to peroxidative damage to membranes of the skin and contributing to the exacerbation of lesions.…”

Section: Introductionmentioning

confidence: 99%

Screening of flavonoid “quercetin” from the rhizome of Smilax china Linn. for anti–psoriatic activity

Vijayalakshmi¹,

Ravichandiran²,

Velraj³

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

“…It is a multifactorial immunologic disease in which patients inherit the predispostion to develop psoriasis [4]. Psoriasis is characterized by hyperproliferation and abnormal differentiation of epidermal keratinocytes, infiltration by T-lymphocytes [5]. The exact cause of psoriasis is still unknown [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Healing Effect of Moringa oleifera Lam against UV-B Induced Psoriasis form Changes in Rats

Dilawar¹,

Shah²,

Hussain³

et al. 2017

Biochem Pharmacol (Los Angel)

View full text Add to dashboard Cite

Moringa oleifera extracts have been used in herbal medicines by various communities in different parts of the world. It is a multipurpose tree with a magnificent profile of medicinal uses, high nutritional values and pharmacological activities. Various parts of this plant such as the flower, seed, immature pod, stem bark, leaf and root, possesses anti-oxidant, anticancer, antimicrobial, anti-ulcer, anti-hepatotoxic, antihypertensive, antihyperlipidemia, antidiabetic, antispasmodic, antiepileptic, antipyretic, anti-inflammatory and analgesic properties. An attempt was made to evaluate the healing properties of the methanolic extract of different aerial parts of Ultraviolet light-B was used to induce psoriasisform changes in rats. Irradiated rats were divided into 8 groups (6 rats/groups). The first group left untreated served as a control were given normal lab feed and a second group which served as the standard was administered retinoic acid (0.5 mg/kg) orally. Group III to Group VIII were administered orally with the methanolic extracts from aerial parts of M. oleifera (200 mg/kg bw) and (400 mg/kg bw). Data collected in this study was analyzed using statistical package for social sciences (SPSS) version 16. There was a significant difference (P<0.05) in epidermal thickness of control and drugs treated group. The methanolic extracts from aerial parts of M. oleifera used for treatment, enhanced fibroplasia, reduced inflammation and produced high amounts of scar tissue and enhanced the rate of wound healing and re-epithelisation compared to control. The plant extracts were effective against psoriasiform changes in rats. Though, more studies are required to assess which of its known ingredients are responsible for the antipsoriatic effects. The constituents of M. oleifera should be considered for further studies.

show abstract

Psoriasis and metabolic disease: epidemiology and pathophysiology

Cited by 252 publications

References 50 publications

Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells

Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells

Screening of flavonoid “quercetin” from the rhizome of Smilax china Linn. for anti–psoriatic activity

Healing Effect of Moringa oleifera Lam against UV-B Induced Psoriasis form Changes in Rats

Contact Info

Product

Resources

About