Screening of flavonoid “quercetin” from the rhizome of Smilax china Linn. for anti–psoriatic activity

Vijayalakshmi, A.; Ravichandiran, V.; Velraj, Malarkodi; Nirmala, Sankaradoss; Jayakumari, S.

doi:10.1016/s2221-1691(12)60021-5

Cited by 66 publications

(44 citation statements)

References 14 publications

(19 reference statements)

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“…Amazon' da birçok şaman ve tıp adamı lepra ve cilt hastalıklarının (psoriasis ve dermatit) tedavisinde kullanmıştır (23). Klinik araştırmalar sedef hastalığı, egzama, akne ve cüzzam gibi cilt hastalıkları için geleneksel sarsaparilla kullanımını doğrulamıştır (24). …”

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Sedef Hastalığında kullanılan Aloe vera, Smilax excelsa ve Juniperus oxycedrus Bitkilerinin Yaprak Anatomik Özellikleri

Koçyiğıt¹,

Tümer²

2017

Marmara Pharmaceutical Journal

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ÖZSedef hastalığı-psöriazis (psoriazis), keskin sınırlı, eritemli plak veya papüller üzerinde yerleşmiş parlak, sedefi-beyaz pullarla karakterize, kronik seyirli, bulaşıcı olmayan inflamatuvar bir hastalıktır. Pulların renginden dolayı halk arasında 'Sedef Hastalığı' olarak bilinmektedir. Bu çalışmada Türkiye' de halk arasında sedef hastalığında kullanılan bitkilerden üçünün

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Sedef Hastalığında kullanılan Aloe vera, Smilax excelsa ve Juniperus oxycedrus Bitkilerinin Yaprak Anatomik Özellikleri

Koçyiğıt¹,

Tümer²

2017

Marmara Pharmaceutical Journal

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“…[37] Such reports have shown that best docked analogues of quercetin and kaempferol do have favorable ligand-protein molecular interactions, similar to the interaction of cyclosporin A with calcineurin. [33] In our present docking analysis, datasets of 80 analogues each of kaempferol and quercetin flavonoids were docked at the active site of calcineurin protein using PyRx software.…”

Section: Discussionmentioning

confidence: 99%

Virtual Screening and Docking Analysis of Novel lavonoidanalogues as Antipsoriaticagents

2018

IJCRR

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Introduction: Psoriasis is an immune-mediated chronic, inflammatory skin disease characterized by hyper proliferative keratinocytes and their infiltration into the dermis of T cells, dendritic cells, macrophages and neutrophils. There is ample evidence suggesting the key role of dysregulation of immune cells in the skin, particularly T cells, in the pathogenesis of psoriasis. Calcineurin, a calcium and calmodulin dependent serine/threonine protein phosphatase plays a major role in increasing the production of T cells and thus in the development of psoriasis. Flavonoids such as quercetin and kaempferol are known to inhibit development of psoriasis.

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“…This characteristic could be advantageous for the treatment of multi-causal diseases caused by oxidative stress, including psoriasis. In an earlier work, Vijayalakshmi et al .,[14] reported that the flavonoid quercetin showed significant reduction in epidermal thickness with respect to control in Perry's mouse tail model. Jadranka Skuric et al .,[15] reported that the flavonoids from propolis offer some protection against psoriatic complications through their roles as inhibitors of inflammation and as free-radical scavengers on animal model psoriasis, induced by the di-n-propyl disulfide irritant (PPD).…”

Section: Discussionmentioning

confidence: 99%

Anti-psoriatic activity of Givotia rottleriformis in rats

Vijayalakshmi¹,

Geetha²

2014

Indian J Pharmacol

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Objectives:To evaluate the antipsoriatic activity of Givotia rottleriformis bark in rats.Materials and Methods:The antipsoriatic activity of the ethanol extract was investigated using ultraviolet B (UV-B)-induced photodermatitis model in rats. The animals were divided into four groups (6/groups). The vehicle-control group animals received normal saline (10 ml/kg, p.o.) and standard group received retinoic acid (0.5 mg/kg, p.o.). Remaining groups were treated orally with the ethanolic extract of bark of Givotia rottleriformis (200 and 400 mg/kg, p.o.) and data were analyzed using one-way analysis of variance (ANOVA). The extract was standardized using chemical markers by high-performance liquid chromatography (HPLC) analysis.Results:In case of psoriasis model, histopathological analysis revealed that in the section, there were absence of Munro's microabscess, elongation of rete ridges, and capillary loop dilation in ethanol extract (400 mg/Kg) and standard group. The ethanolic extract (200 and 400 mg/Kg) exhibited significant reduction (P < 0.01) in percentage of relative epidermal thickness as compared with positive control. In the HPLC analysis, 4 flavonoids were quantified by comparison to a calibration curve derived from the standard, rutin (0.215 mg/gm) quercetin (1.36 mg/gm), kaempferol (6.36 mg/gm) and luteolin (8.64 mg/gm).Conclusion:The crude extract containing ethanolic extract of Givotia rottleriformis bark have potent antipsoriatic activity in UV-B-induced psoriasis in rat.

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Screening of flavonoid “quercetin” from the rhizome of Smilax china Linn. for anti–psoriatic activity

Cited by 66 publications

References 14 publications

Sedef Hastalığında kullanılan Aloe vera, Smilax excelsa ve Juniperus oxycedrus Bitkilerinin Yaprak Anatomik Özellikleri

Sedef Hastalığında kullanılan Aloe vera, Smilax excelsa ve Juniperus oxycedrus Bitkilerinin Yaprak Anatomik Özellikleri

Virtual Screening and Docking Analysis of Novel lavonoidanalogues as Antipsoriaticagents

Anti-psoriatic activity of Givotia rottleriformis in rats

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