Psoralen Prophylaxis Against Skin Cancer: Report of Clinical Trial II

Hopkins, Carl E.; Belisario, John C.; Macdonald, Eleanor J.; Davis, Charlotte T.

doi:10.1038/jid.1963.99

Cited by 15 publications

(3 citation statements)

References 14 publications

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“…The important genera of plants that contain furocoumarins are the Umbelliferae (eg, parsley) and Rutaceae (eg, citrus). Only a few, but very widely used, furocoumarin-containing plant species belong to the Leguminosae (eg, beans), and Moraceae (eg, figs).6 So far, 28 different furocoumarins have been iso¬ lated from natural sources. Only psoralen, methoxsalen (Xanthotoxin) and 5-methoxypsoralen (Bergapten) have been found to in¬ duce cutaneous photosensitization and melanogenesis effectively.…”

mentioning

confidence: 83%

Hydroquinone and Psoralens in the Therapy of Hypermelanosis and Vitiligo

Fitzpatrick¹,

Arndt²,

El-Mofty³

et al. 1966

Arch Dermatol

112

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mentioning

confidence: 83%

Hydroquinone and Psoralens in the Therapy of Hypermelanosis and Vitiligo

Fitzpatrick¹,

Arndt²,

El-Mofty³

et al. 1966

Arch Dermatol

112

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“…8-MOP was also tested as a prophylaxis against skin cancer and it was found that the effect of the therapy was nil [9,10]. The aim of this study was to investigate the effects of 8-MOP and UV treatment on fibroblast cells cultured over a long period in vitro and to find a correlation with the events occurring in the skin of patients who had been treated with the prescribed therapy (PUVA) [7,8],…”

Section: -Methoxypsoralenmentioning

confidence: 99%

Induction of Multinucleate Cells by 8-MOP and UV Treatment <i>in vitro</i> and <i>in vivo</i>

Omar¹,

Wiesmann²,

Krebs³

1977

Dermatology

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Fibroblast cells were treated with a single dose of 8-methoxypsoralen (8-MOP) and long-wave UV irradiation in vitro and the cytotoxic effects of the treatment followed up for 5 passages. During the first passage, there was an inhibition in cell proliferation, the induction of chromosomal aberrations and the production of macrocells as well as cells with more than one nucleus. In the subsequent passages, the proliferation rate of the cells gradually normalized but there was a concomitant increase in chromosomal aberrations and in the number of macrocells and multinucleate cells. Specimens, which were taken from the uninvolved skin of psoriatic patients who had been treated between 20 and 40 times with an oral dose of 8-MOP and black light irradiation (PUVA) also revealed the presence of binucleate, tetranucleate and multinucleate epidermal cells as well as binucleate and tetranucleate dermal fibroblasts.

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“…8-MOP can be used both locally and orally, each having its advantages and disadvantages (Table i). Since the discussions ofthe possible systemic side effects of 8-MOP (Becker, i960;Griffin, 1959;Hopkins et a/., 1963;Joseph et al, 1974;Langner et al, 1975;O'Neal & Griffin, 1957;Townsend, Wright & Hopwood, 1971;Urbach, 1959;Urbach, Forbes & Davies, 1975) are yet to be concluded, one of our first aims was to simplify the local application of 8-MOP.…”

mentioning

confidence: 99%

Simplification of local therapy of psoriasis with 8-methoxypsoralen.

Schaefer

Kentsch

et al. 1976

Br J Dermatol

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Local 8-methoxypsoralen black-light treatment was carried out on sixty-two patients. For the first time, oil was employed as a preparation base in order to increase the transparency and so the effectiveness of irradiation. Also the need for a descaling pretreatment was avoided. In investigations still being carried out, 27.5% patients showed very good improvement, 48-4% good and 24-2% unsatisfactory results of treatment. In many cases, less than fifteen irradiation sessions were necessary for clinical healing. However, to obtain a uniform pigmentation, additional irradiation proved necessary.

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Psoralen Prophylaxis Against Skin Cancer: Report of Clinical Trial II

Cited by 15 publications

References 14 publications

Hydroquinone and Psoralens in the Therapy of Hypermelanosis and Vitiligo

Hydroquinone and Psoralens in the Therapy of Hypermelanosis and Vitiligo

Induction of Multinucleate Cells by 8-MOP and UV Treatment <i>in vitro</i> and <i>in vivo</i>

Simplification of local therapy of psoriasis with 8-methoxypsoralen.

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