Psilocybin Efficacy and Mechanisms of Action in Major Depressive Disorder: a Review

Prouzeau, Damien; Conejero, Ismaël; Voyvodic, Peter L.; Bécamel, Carine; Abbar, Mocrane; López-Castromán, Jorge

doi:10.1007/s11920-022-01361-0

Cited by 17 publications

(18 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A related and essential question is "how does psychedelic therapy work?" Already, several theories propose mechanisms of action, 3 ranging from cellular to behavioral (Figure). These proposed mechanisms are not mutually exclusive and likely interact in ways that are key to the assumed action, representing interactive and superimposed levels of a dynamic system.…”

Section: What Are the Therapeutic Mechanisms Of Action?mentioning

confidence: 99%

Emerging Challenges for Psychedelic Therapy

2023

View full text Add to dashboard Cite

show abstract

Section: What Are the Therapeutic Mechanisms Of Action?mentioning

confidence: 99%

Emerging Challenges for Psychedelic Therapy

2023

View full text Add to dashboard Cite

show abstract

“…This evidence suggests that, despite the therapeutic effect on psychotically healthy people as mentioned previously, the ingestion of psilocybin could result in the exacerbation of mental illness or even the onset of mental illness. However, these appeared side effects are considered mild, and limited to a short period after dosing [22].…”

Section: Side Effectmentioning

confidence: 99%

Application of psilocybin in mental health disorders

Chen

2023

TNS

View full text Add to dashboard Cite

Psilocybin is a naturally occurring psychoactive compound, which has been used for ages in traditional settings for religious and therapeutic use. Recent studies have renewed interest in psilocybin for its potential therapeutic benefits in treating depression and anxiety. The pharmacodynamics of psilocybin are complex, involving its rapid conversion to psilocin and its activity on various serotonin receptors, particularly the 5HT2A/C and 5HT1A receptors. In addition, psilocybin can increase glutamate release, which is believed to be an important mechanism underlying its therapeutic effects. Clinical trials have demonstrated that psilocybin has a long-lasting antidepressant effect, with little to no side effects. However, it is necessary to further study the mechanisms underlying its therapeutic potential and to optimize its use in clinical settings. Overall, the promising findings suggest that psilocybin may offer a valuable alternative to traditional antidepressant therapies for individuals suffering from depression and anxiety. Meanwhile, studies have shown that this drug also has certain benefits for mental disorders such as addiction and obsessive-compulsive disorder. Thus, it is necessary to continue exploring the potential of psilocybin as a novel strategy in treating mental health disorders.

show abstract

“…Psilocybin has shown promise as a novel pharmacological intervention for treatment of depression, where post-acute effects of psilocybin treatment have been associated with increased positive mood and decreased pessimism (1)(2)(3). Although accumulating evidence indicates that psilocybin is effective for treatment of psychiatric disorders, the information processing mechanisms underlying the effects of psilocybin are not well understood (4,5). Establishing the information processing mechanisms of psilocybin could significantly benefit our understanding of the drug's therapeutic actions, potentially helping to improve its efficacy and specificity, which could assist in informing clinical decisions.…”

Section: Introductionmentioning

confidence: 99%

“…𝑔(𝐸(𝑦)) = β 0 + 𝛽 1 𝐺𝑟𝑜𝑢𝑝 + 𝑓(𝐷𝑎𝑦, 𝑏𝑦 = 𝐺𝑟𝑜𝑢𝑝) + 𝑓 𝐼𝐷 (𝐷𝑎𝑦) + 𝜖, where Group encoded a two-level factor variable reflecting treatment allocation (psilocybin, control) and Day encoded the consecutive sequence of test sessions(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Thin-plate regression splines(43) were used to model changes in 𝑦 over Day for each level of Group.…”

mentioning

confidence: 99%

Psilocybin increases optimistic engagement over time: computational modelling of behavior in rats

Fisher,

Smith,

Corcoran

et al. 2024

Preprint

View full text Add to dashboard Cite

Psilocybin has shown promise as a novel pharmacological intervention for treatment of depression, where post-acute effects of psilocybin treatment have been associated with increased positive mood and decreased pessimism. Although psilocybin is proving to be effective in clinical trials for treatment of psychiatric disorders, the information processing mechanisms affected by psilocybin are not well understood. Here, we fit computational models of underlying decision-making mechanisms to behaviour in rats. The model revealed that rats treated with psilocybin achieve more rewards through increased task engagement, mediated by modification of forgetting rates and reduced loss aversion. These findings suggest that psilocybin may afford an optimism bias that arises through altered belief updating, with translational potential for clinical populations characterised by lack of optimism.

show abstract

Psilocybin Efficacy and Mechanisms of Action in Major Depressive Disorder: a Review

Cited by 17 publications

References 54 publications

Emerging Challenges for Psychedelic Therapy

Emerging Challenges for Psychedelic Therapy

Application of psilocybin in mental health disorders

Psilocybin increases optimistic engagement over time: computational modelling of behavior in rats

Contact Info

Product

Resources

About