Pseudopeptosomes: non-lipidated vesicular assemblies from bispidine-appended pseudopeptides

Abstract

We present a molecular topology-based strategy for creating pseudopeptosomes. These pseudopeptides showed cell penetrating property. X-ray crystal structure and spectroscopic data revealed a Trp zipper arrangement.

Pleomorphism in Biological Units of Life: Morphological Heterogeneity in Cells Does Not Translate Uniformly to Subcellular Components

“…Interestingly, nonbiological and artificial emergent systems lack such variations in independent or dependent relations of the “parts with the whole”. 5 , 43 As we delve deeper into the intricacies of cellular structure, our study lays the foundation for future explorations into the emergent properties of natural biological systems toward a holistic understanding of cellular life.…”

“…“In the case of all things which have several parts and in which the totality is not, as it were a mere heap, but the whole is something besides the parts , ...,” an Aristotle quote has been inspiring numerous researchers to delve into the areas of the emergent nature of various systems in pursuit of understanding the origin of life to ultimately construct an artificially emergent system . Apart from numerous lipid-based vesicles, nonlipids are also being used to study the emergent behavior of biological systems while attempting to define an application area of such systems. − We earlier studied the structural characteristics of reversible self-assemblies of bispidine pseudopeptides, the vesicle of which found their use in the cellular uptake of therapeutic molecules . However, it is imperative to study readily accessible naturally emergent systems, cells ( the basic functional units of life ), and their components thoroughly to gain better insights into the emergence of collective structural properties of biological systems, which recent advances in the field have demonstrated.…”

“… 4 − 6 We earlier studied the structural characteristics of reversible self-assemblies of bispidine pseudopeptides, the vesicle of which found their use in the cellular uptake of therapeutic molecules. 5 However, it is imperative to study readily accessible naturally emergent systems, cells ( the basic functional units of life ), and their components thoroughly to gain better insights into the emergence of collective structural properties of biological systems, which recent advances in the field have demonstrated.…”

Zinc-Induced Luminescent l-Valine-Based Pseudopeptidic Soft Bioinspired Materials for Precise Tuning of Nanoassembly

“…Nature uses molecular self-assembly to construct advanced functional structures by using amino acid building blocks. It is a basic structural unit of protein, peptides, and essential building blocks for all living organisms. − Therefore, amino acid-derived macrocyclic and open-chain molecules show much attention in fields like medicine, synthetic, bioorganic, and supramolecular chemistry . In this context, many efforts have been devoted for developing a moiety constructed from a combination of amino acids with non-natural units for their coordination with numerous metal ions.…”

Expanded triazolophanes: a topological analysis of vesicular assembly

“…Designing molecules that self-assemble into a variety of 2D and 3D structures such as nanotubes, toroids, and vesicles have attracted the interests of chemists. [1][2][3][4][5] Among them, vesicles hold a special place due to their resemblance to cells and their potential applications in biology, chemistry and material sciences. [6][7][8][9] Generally, vesicles are formed from the self-assembly of amphiphilic molecules in solution.…”