Macrocyclic compounds M1-M3 with different ring sizes containing amide and triazole units were synthesized. These triazolophanes displayed a variety of self-assembled structures such as hemi-toroids, toroids, and vesicles in a concentration dependent manner. Detailed ultramicroscopic and crystallographic investigations delineated a hierarchical mechanism of self-assembly.
Anion receptors have attracted growing interest because of their role in chemistry, the environment, biology and medicine. The mis-regulation of anion flux causes a variety of lethal human diseases. Recently, triazole has been found to be an excellent motif for molecular recognition. This review depicts an overall picture of developments in the design and synthesis of anion receptors along with an up-to-date emphasis on the triazole unit as a motif for anion recognition. The acidic CH of triazole is involved in binding with the anions, which makes these receptors different from other classes of receptors. The chemo-and regio-selectivity of the click reaction provides further impetus for future developments in this area.
We report a series of hybrid peptide molecules that display spontaneous vesiculation. A closer look at their vesicle formation revealed a toroidal intermediate en route to the final vesicular form.
We report cystine-based macrocyclic compounds showing very unique self-assembling behavior. 24-membered disulfide macrocycle 3 shows a helical and tubular organization and also forms an insoluble plaque that is birefringent with congo red dye. 48-membered macrocycle 4 shows a vesicle-like assembly with capability for encapsulation, as demonstrated by rhodamine B encapsulation.
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