Triazole: a new motif for anion recognition

Abstract

Anion receptors have attracted growing interest because of their role in chemistry, the environment, biology and medicine. The mis-regulation of anion flux causes a variety of lethal human diseases. Recently, triazole has been found to be an excellent motif for molecular recognition. This review depicts an overall picture of developments in the design and synthesis of anion receptors along with an up-to-date emphasis on the triazole unit as a motif for anion recognition. The acidic CH of triazole is involved in binding with the anions, which makes these receptors different from other classes of receptors. The chemo-and regio-selectivity of the click reaction provides further impetus for future developments in this area.

Influence of the Substitution and Conformation of CH‐Bond‐Based Bis‐Triazole Acceptors in Anion‐Binding Catalysis

“…In our initial studies, [12] a new family of bis (1,2,3-triazole)s [13] BisTri was designed to develop C À H-based anion accept-ors [14][15][16] for anion-binding organocatalysis. The alkylation of several amines with N-trityldimethylaminopyridinium chloride as ionic electrophile was chosen as model reaction (Scheme 1).…”

1-[4-(Dimethylamino)benzylidene]-4-o-tolylthiosemicarbazide

“…For details of anion recognition, see: Sessler et al (2006); Amendola et al (2006); Fahlbusch et al (2006); Gale & Quesada (2006); Perez & Riera (2008); Willans et al (2009); Amendola & Fabbrizzi (2009); Haridas et al (2012). For applications of thiosemicarbazides, see: Basuli et al (1998); Pandeya et al (1999); Kowol et al (2010).…”

Synthesis, Optical and Antibacterial, Antifungal Studies on Functionalized Triazolophanes: A New Class of Cyclophane

“…The optical properties of the synthesized triazolophanes would be more interesting and the electron acceptor nature of the nitro substituted functionality in the triazolophanes 7 and the oxadiazole unit in the triazolophane 9 would significantly alter the optical properties. The UV-vis absorption and emission spectra of triazolophanes 1-9 were recorded in CHCl 3 at a concentration of 1 3 10 À5 M and the lmax and lem values are summarized in Table 1. In the absorbance spectrum, the triazolophanes 1-9 showed two absorption bands between 243-251 nm and 290-315 nm (Figure 2a).…”

“…The 13 C NMR spectrum of the triazolophane 1 showed three signals at d 39.5, 51.0 and 62.7, NH-methylene, N-methylene, O-methylene and the triazole carbon at d 130. 3,138.7 in addition to the signals for aromatic carbons. The appearance of molecular ion peak at m/z 373 in the mass spectrum and the elemental analysis also confirmed the structure of the triazolophane 1.…”