Pseudomyxoma Peritonei: Case Report and Literature Review

Garcia, Keishla M; Flores, Karla M.; Ruiz, Alejandro; González, F López; Rodríguez, Ángel M

doi:10.1007/s12029-018-00192-8

Cited by 6 publications

(5 citation statements)

References 60 publications

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“…[ 25 – 27 ] Our results also recognized advanced age as an independent risk factor while predicting OS and CSS of PMP patients. In accordance with our findings, previous studies have demonstrated that the average age when PMP occurs is 53 years [ 28 , 29 ] ; further, age is a crucial survival-related factor in patients with PMP. [ 30 ] In addition, tumor differentiation degree is an important prognostic factor in cancer patients.…”

Section: Discussionsupporting

confidence: 93%

Development and validation of prognostic nomograms for pseudomyxoma peritonei patients after surgery

Chen¹,

Su²,

Yang³

et al. 2020

Medicine

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Background: The aim of study was to develop and validate nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) of patients with pseudomyxoma peritonei (PMP) and compare the predictive accuracy with the American Joint Committee on Cancer (AJCC) staging system. Methods: Data of 4959 PMP patients who underwent surgical resection were collected between 2004 and 2015 from the Surveillance Epidemiology and End Results (SEER) database. All included patients were divided into training (n = 3307) and validation (n = 1652) cohorts. The Kaplan–Meier method and Cox proportional hazard model were applied. Nomograms were validated by discrimination and calibration. Finally, concordance index (C-index) was used to compare the predictive performance of nomograms with that of the AJCC staging system. Results: According to the univariate and multivariate analyses of training sets, both nomograms for predicting OS and CSS combining age, grade, location, N stage, M stage, and chemotherapy were identified. Nomograms predicting OS also incorporated T stage and the number of lymph nodes removed (LNR). The calibration curves showed good consistency between predicted and actual observed survival. Moreover, C-index values demonstrated that the nomograms predicting both OS and CSS were superior to the AJCC staging system in both cohorts. Conclusion: We successfully developed and validated prognostic nomograms for predicting OS and CSS in PMP patients. Two nomograms were more accurate and applicable than the AJCC staging system for predicting patient survival, which may help clinicians stratify patients into different risk groups, tailor individualized treatment, and accurately predict patient survival in PMP.

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Section: Discussionsupporting

confidence: 93%

Development and validation of prognostic nomograms for pseudomyxoma peritonei patients after surgery

Chen¹,

Su²,

Yang³

et al. 2020

Medicine

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“…A specific sonography marker is the so-called "onion skin sign" and its "dumbbell structure" [18]. Typical CT appearance is 'scalloping' of the surface of the liver and spleen, which distinguishes mucinous from fluid ascites [1,11]. A computed tomography scan can also show low-attenuation lesions or loculated ascites scattered throughout the peritoneal cavity and individual peritoneal or omental nodules (omental cake in advance disease).…”

Section: Diagnosismentioning

confidence: 99%

“…Pseudomyxoma peritonei (PMP) is a rare and an uncommon condition, characterized by the presence of mucinous ascites in the abdominal cavity [1,2]. The most common cause of PMP is mucinous adenocarcinoma of the appendix, followed by neoplasm of the ovary, endocervix, fallopian tube alimentary organs, urachus, urinary bladder, lung, mucinous cyst of the spleen, and breast [3,4].…”

Section: Introductionmentioning

confidence: 99%

Pseudomyxoma peritonei of appendiceal origin mimicking ovarian cancer – a case report with literature review

Kostov

Kornovski²,

Slavchev³

et al. 2021

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Pseudomyxoma peritonei (PMP) is a rare and uncommon condition, characterized by the presence of mucinous ascites in the abdominal cavity. The most common cause of PMP is mucinous adenocarcinoma of the appendix, followed by neoplasms of the ovary, endocervix, fallopian tube, alimentary organs, urachus, urinary bladder, lung, mucinous cyst of the spleen, and breast.Herein, we report a case of a 64-year-old postmenopausal woman (gravida 2, para 2) who presented at the department of gynecology with a short history of nausea and abdominal distention. Abdominal and vaginal ultrasonography showed a large amount of free fluid in the pelvis with hyperechoic echogenicity and right pelvic tumor with mixed echogenicity. Computed tomography demonstrated the presence of a heterogeneous, hypodense mass, without contrast enhancement, located on the right side of the pelvis, near the right ovary. Laparotomy was performed. Revision of the abdominal cavity revealed a large amount of yellow gelatinous mucinous ascites -approximately 1.5 l. A tumor (6 x 7 cm in diameter), arising from the appendix and located in the pouch of Douglas near the right ovary, was observed. Histopathology examination revealed poorly differentiated mucinous appendiceal adenocarcinoma, comprising up to 50% signet ring cells.Gastrointestinal tumors such as appendiceal neoplasms combined with PMP may mimic ovarian carcinomas. Computed tomography, abdominal/vaginal ultrasonography and tumor marker levels (carcino-embryonic antigen, carbohydrate antigen 19.9, carbohydrate antigen Ca-125) may establish the diagnosis.A differential diagnosis with appendiceal tumors should be considered for patients with right pelvic masses.

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“…1 PMP, described as "jelly belly," is featured with the intraperitoneal accumulation of mucin produced by malignant mucus-secreting cells in the peritoneum or omentum, which contributes to scattering and progressively aggravating mucinous ascites and gelatinous masses. 2,3 The first clinical case conformed to PMP appeared in 1842, as described by Rokitansky. 4 It was in 1884 that Werth initially put forward the term PMP and explained the origin that concerned with a mucinous carcinoma of the ovary.…”

mentioning

confidence: 96%

“…Pseudomyxoma peritonei (PMP) is an infrequent clinical disease with an estimated prevalence of 1 to 3 persons per million annually 1. PMP, described as “jelly belly,” is featured with the intraperitoneal accumulation of mucin produced by malignant mucus-secreting cells in the peritoneum or omentum, which contributes to scattering and progressively aggravating mucinous ascites and gelatinous masses 2,3. The first clinical case conformed to PMP appeared in 1842, as described by Rokitansky 4.…”

mentioning

confidence: 99%

Comprehensive Understanding and Evolutional Therapeutic Schemes for Pseudomyxoma Peritonei

Zheng

2022

American Journal of Clinical Oncology

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Pseudomyxoma peritonei is an infrequent solid tumor in clinical practice. The low morbidity and deficient understanding of this mucus-secreting malignant disease increase the risks of delayed identification or uncontrollable deterioration. In quite a lot cases, patients go through complete cytoreduction surgery and hyperthermic intraperitoneal chemotherapy could receive a long time survival over 5 years. But the recurrence rate is also hard to overlook. Unlike other types of cancer, the standard treatment for this considerable groups has not been confirmed yet. With the advanced medical progression, studies have been carrying out based on pathogenesis, biological characters, and mutated gene location. All but a few get statistical survival benefits, let alone the breaking progress on research or therapeutic practice in the field. We try to give a comprehensive exposition of pseudomyxoma peritonei around the epidemiology, radiologic features, clinical manifestation, present treatment and promising schemes, hoping to arise much attention and reflection on the feasible solutions, especially for the recrudescent part.

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Pseudomyxoma Peritonei: Case Report and Literature Review

Cited by 6 publications

References 60 publications

Development and validation of prognostic nomograms for pseudomyxoma peritonei patients after surgery

Development and validation of prognostic nomograms for pseudomyxoma peritonei patients after surgery

Pseudomyxoma peritonei of appendiceal origin mimicking ovarian cancer – a case report with literature review

Comprehensive Understanding and Evolutional Therapeutic Schemes for Pseudomyxoma Peritonei

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