Comprehensive Understanding and Evolutional Therapeutic Schemes for Pseudomyxoma Peritonei

Ye, Suiting; Zheng, Song

doi:10.1097/coc.0000000000000911

Cited by 2 publications

(2 citation statements)

References 111 publications

(226 reference statements)

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“…That had also improved people’s confidence in the effectiveness of chemotherapy for MARP. In addition, the research of Ye S et al [ 9 ] shows that intraperitoneal hyperthermic perfusion chemotherapy has a good effect on peritoneal pseudomyxoma. This also increases the treatment methods and treatment confidence for patients with intraperitoneal metastasis of MARP.…”

Section: Discussionmentioning

confidence: 99%

Nephron-sparing surgery for primary mucinous adenocarcinoma of renal pelvis in horseshoe kidney: A case report

Zhang

Wang

et al. 2023

Medicine

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Rationale: Mucinous adenocarcinoma of the renal pelvis is extremely rare in malignancy of the renal pelvis, and <100 cases have been reported so far. However, horseshoe kidneys appear to be more prone to this mucinous gland metaplasia. Due to the lack of a specific diagnostic basis, it is difficult to confirm the diagnosis before surgery, which is easy to cause misdiagnosis. Patient concerns: We report a 64-year-old male patient who found a cystic mass in the left kidney during physical examination. CT examination showed a horseshoe kidney with a cystic mass 9.5 × 8.0 cm in front of the left kidney, lacking obvious diagnostic features. Diagnosis: It was misdiagnosed as cystic teratoma before the operation, and was diagnosed as mucinous adenocarcinoma of the renal pelvis through pathological examination after the operation. Interventions: Resection of the tumor by nephron-sparing surgery and postoperative chemotherapy. Outcomes: No tumor recurrence was found at 6 years of follow-up. After 7 years, the patient had multiple metastases in the abdominal wall and peritoneum, and no tumor recurrence was found in the urinary system. The patient received chemotherapy again and survived well. Lessons: The prognosis of nephron-sparing tumor resection for MRAP is not significantly different from that of radical nephroureterectomy + bladder cuff excision. Because it can reduce the risk that patients can not tolerate follow-up chemotherapy due to abnormal renal function after surgery, which may be more beneficial in patients with kidney abnormalities or chronic disease.

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Section: Discussionmentioning

confidence: 99%

Nephron-sparing surgery for primary mucinous adenocarcinoma of renal pelvis in horseshoe kidney: A case report

Zhang

Wang

et al. 2023

Medicine

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“…The Peritoneal Surface Oncology Group International (PSOGI) classification, which has been validated on several occasions ( 7 , 8 ), divides PMP into four groups based on histological characteristics: i) acellular mucin (AM), ii) low-grade mucinous carcinoma (LG-PMP), iii) high-grade mucinous carcinoma (HG-PMP), and iv) PMP with the presence of signet ring cells (SRC) ( 4 ). However, histopathology does not completely predict tumor behavior ( 9 ). On the other hand, mucin from PMP is classified into soft, semi-hard, and hard mucin samples based on physical and chemical properties as well as visual appearance ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Intraoperative oxygen tension and redox homeostasis in Pseudomyxoma peritonei: A short case series

et al. 2023

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IntroductionPseudomyxoma peritonei (PMP) is a rare malignant disease characterized by a massive multifocal accumulation of mucin within the peritoneal cavity. The current treatment option is based on complete cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy. However, the recurrence is frequent with subsequent progression and death. To date, most of the studies published in PMP are related to histological and genomic analyses. Thus, the need for further studies unveiling the underlying PMP molecular mechanisms is urgent. In this regard, hypoxia and oxidative stress have been extensively related to tumoral pathologies, although their contribution to PMP has not been elucidated.MethodsIn this manuscript, we have evaluated, for the first time, the intratumoral real-time oxygen microtension (pO2mt) in the tumor (soft and hard mucin) and surrounding healthy tissue from five PMP patients during surgery. In addition, we measured hypoxia (Hypoxia Inducible Factor-1a; HIF-1α) and oxidative stress (catalase; CAT) markers in soft and hard mucin from the same five PMP patient samples and in five control samples.ResultsThe results showed low intratumoral oxygen levels, which were associated with increased HIF-1α protein levels, suggesting the presence of a hypoxic environment in these tumors. We also found a significant reduction in CAT activity levels in soft and hard mucin compared with healthy tissue samples.DiscussionIn conclusion, our study provides the first evidence of low intratumoral oxygen levels in PMP patients associated with hypoxia and oxidative stress markers. However, further investigation is required to understand the potential role of oxidative stress in PMP in order to find new therapeutic strategies.

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Comprehensive Understanding and Evolutional Therapeutic Schemes for Pseudomyxoma Peritonei

Cited by 2 publications

References 111 publications

Nephron-sparing surgery for primary mucinous adenocarcinoma of renal pelvis in horseshoe kidney: A case report

Nephron-sparing surgery for primary mucinous adenocarcinoma of renal pelvis in horseshoe kidney: A case report

Intraoperative oxygen tension and redox homeostasis in Pseudomyxoma peritonei: A short case series

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