Pseudomonas aeruginosa multiresistente em unidade de cuidados intensivos: desafios que procedem?

Ferrareze, Maria Verônica Guilherme; Leopoldo, Vanessa Cristina; Andrade, Denise de; Silva, Magda Fabbri Issac; Haas, Vanderlei José

doi:10.1590/s0103-21002007000100002

Cited by 14 publications

(12 citation statements)

References 32 publications

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“…A study [44] reported the presence of MDR Enterobacteria in 22.2% of 18 sampled surfaces, which is consistent with our findings (19.44%) for the AICU of Hospital A. European data [45] showed a high level of contamination by P. aeruginosa in sink isolates and tap biofilms. In line with this, our study recovered P. aeruginosa from 25% of sink samples, which attests that this pathogen is commonly associated with humid sites in the hospital environment and is the main microorganism isolated in ICUs [46]. In contrast, from a total of seventeen P. aeruginosa isolates found in this study, eleven were non-MDR isolates from door knobs of the ER, which is not a humid environment.…”

Section: Discussionsupporting

confidence: 84%

Epidemiology of bacterial contamination of inert hospital surfaces and equipment in critical and non-critical care units: a Brazilian multicenter study

Rodrigues

Peixoto²,

Barros³

et al. 2019

Preprint

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27The hospital environment is an important reservoir of microorganisms, including 28 multidrug-resistant pathogens, which can cause in-patient contamination and healthcare-29 related infections. The objective of this study was to analyze the epidemiology of bacterial 30 contamination (contaminated sites, pathogen species and their antimicrobial 31 susceptibility, and tracking of multidrug-resistant microorganisms -MDR) of inert 32 hospital surfaces and medical equipment in two public hospitals in Northern Brazil. 33 This was a cross-sectional study with 243 samples (n = 208, from Hospital A; and n = 35, 34 from Hospital B) collected by friction with swabs moistened in Brain Heart Infusion from 35 inert surfaces and equipment. The samples were cultivated and bacterial species were 36identified by the classical approach and tested for their susceptibility through agar 37 diffusion assay according to the Clinical and Laboratory Standards Institute (CLSI). 38Most inert surfaces and equipment analyzed presented bacterial contamination (95.5%). 39Staphylococcus aureus was the main pathogen of clinical significance detected both in 40 Hospital A (61.8%) and B (68.6%). Hospital A showed higher rates of isolated MDR 41 bacteria than Hospital B, especially in the Adult Intensive Care Unit, which included 42 methicillin-resistant Staphylococcus aureus (MRSA) (52.7%), Enterobacteria resistant to 43 4 th generation cephalosporins (19.4%), and multidrug-resistant Pseudomonas aeruginosa 44 (2.78%). The failures in the prevention and control of infections in the two hospitals 45 analyzed reinforce the need for a revised protocol for cleaning and disinfection of inert 46 surfaces and medical equipment, and for regulation of antibiotic dispensing, mainly in the 47 AICU of Hospital A, which was found to be a reservoir of MDR pathogens. This study is 48 innovative because it is the pioneer in Western Bahia that describes the epidemiology of 49 contamination of hospital surfaces, opportuning futures studies in this field. 50 Introduction 51Healthcare-associated infections (HAI) are a major public health concern 52 commonly associated with extended length of hospital stay. HAI account for high hospital 53 costs and contribute to increased morbidity and mortality of infected patients [1]. 54HAI are usually caused by pathogenic bacteria that may emerge from the patient's 55 endogenous microflora during antibiotic therapy in approximately 70% of the cases [2,3]. 56HAI may also be acquired from the exogenous environment (30% of the cases) in that the 57 hospital setting plays a significant role in contagion and transmission outbreaks [3,4]. 58In the hospital setting, patients, staff and visitors represent the main reservoir of 59 microorganisms, whereas secondary reservoirs include all environments where nutrients, 60 moisture, and temperature are suitable for microbial survival, such as air humidifiers and 61 nebulizers [5,6]. In addition, dry and inanimate surfaces can also serve as a reservoir of 62 pathogens [3,5,7-9], as in mattre...

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Section: Discussionsupporting

confidence: 84%

Epidemiology of bacterial contamination of inert hospital surfaces and equipment in critical and non-critical care units: a Brazilian multicenter study

Rodrigues

Peixoto²,

Barros³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Com isso, pode-se perceber que a maioria das amostras foi isolada a partir do material do trato respiratório (68%). Esse fato também foi constatado por Menezes et al (26) , o que de certa forma já era esperado, uma vez que relatamos, em nosso estudo, grande quantidade de cepas isoladas de Pseudomonas aeruginosa, microrganismo comum em patologias respiratórias (13,15,35) . Estudando esse patógeno, encontramos a maioria de cepas provindas do trato respiratório.…”

Section: Figura -Perfil De Resistência Aos Antimicrobianos De Pacientunclassified

Prevalência de bacilos Gram-negativos não fermentadores de pacientes internados em Porto Alegre-RS

Deliberali¹,

Myiamoto²,

Neto³

et al. 2011

J. Bras. Patol. Med. Lab.

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“…e 0 r, resulting in approximately 300,000 deaths (Ferrareze et al, 2007). The risk of nosocomial infection is related to the patient's length of stay in hospital, the patient's immunological and nutritional status, patient's age, the use of immunosuppressants and antibiotics and invasive procedures (Ferrareze et al, 2007;Santos, 2004).…”

mentioning

confidence: 99%

Prevalence of resistance and molecular characterization of extended spectrum beta-lactamase (ESBL)-producing bacteria isolated in a hospital in Southern Brazil

Dexheimer¹,

Prediger²,

Weidlich³

et al. 2015

Afr. J. Microbiol. Res.

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Pseudomonas aeruginosa multiresistente em unidade de cuidados intensivos: desafios que procedem?

Cited by 14 publications

References 32 publications

Epidemiology of bacterial contamination of inert hospital surfaces and equipment in critical and non-critical care units: a Brazilian multicenter study

Epidemiology of bacterial contamination of inert hospital surfaces and equipment in critical and non-critical care units: a Brazilian multicenter study

Prevalência de bacilos Gram-negativos não fermentadores de pacientes internados em Porto Alegre-RS

Prevalence of resistance and molecular characterization of extended spectrum beta-lactamase (ESBL)-producing bacteria isolated in a hospital in Southern Brazil

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