Pseudoexfoliation syndrome: <i>in vivo</i> confocal microscopy analysis

Martone, Gianluca; Casprini, Fabrizio; Traversi, Claudio; Lepri, Francesca; Pichierri, Patrizia; Caporossi, Aldo

doi:10.1111/j.1442-9071.2007.01535.x

Cited by 29 publications

(26 citation statements)

References 5 publications

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“…This special endotheliopathy can cause early corneal endothelial decompensation and may have been previously misdiagnosed as an atypical non-guttata Fuchs' endothelial dystrophy (8,18,19) . In addition, in vivo confocal microscopy studies have shown significant morphologic alterations in the corneas of PXS patients (5,(20)(21)(22) . Data are indicated as mean ± standard deviation.…”

Section: Discussionmentioning

confidence: 99%

“…Tissue differentiation predisposes to several intraocular and surgical complications, including glaucoma, zonular dehiscence, phacodonesis and lens subluxation, capsular rupture or vitreous loss during cataract surgery, blood-aqueous barrier dysfunction, and corneal endothelial decompensation (3,4) . In previous studies, the deposition of exfoliation material on the corneal endothelium, decreased endothelial cell density, changes of the basal epithelium with the alterations of the subepithelial nerve plexus, decreased corneal sensation, and dry eye with the disturbances of the precorneal tear film have been reported (5)(6)(7)(8) . However, there are conflicting studies about central corneal thickness (CCT) in patients with PXS or pseudoexfoliative glaucoma.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of anterior segment parameters in patients with pseudoexfoliation syndrome using Scheimpflug imaging

Güneş¹,

Yigit²,

Tök³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Süleyman Demirel University (# 72867572-050). ABSTRACT Purpose:To evaluate anterior segment parameters in patients with pseudoexfoliation syndrome (PXS) using Scheimpflug imaging. Methods: Forty-three PXS patients and 43 healthy control subjects were included in this cross-sectional study. All participants underwent a detailed ophthalmologic examination. Anterior segment parameters were measured using a Scheimpflug system. Results: Considering the PXS and control groups, the mean corneal thicknesses at the apex point (536 ± 31 and 560 ± 31 µm, respectively, p=0.001), at the center of the pupil (534 ± 31 and 558 ± 33 µm, respectively, p=0.001), and at the thinnest point (528 ± 30 and 546 ± 27 µm, respectively, p=0.005) were significantly thinner in PXS patients. Visual acuity was significantly lower (0.52 ± 0.37 versus 0.88 ± 0.23, p<0.001) and axial length was significantly longer (23.9 ± 0.70 mm versus 23.2 ± 0.90 mm, p=0.001) in the PXS eyes than in the control eyes. There were no statistically significant differences in the mean values of keratometry, anterior chamber angle, anterior chamber depth, corneal volume, and anterior chamber volume between the PXS and control eyes. Conclusions: The patients with PXS had thinner corneas, worse visual acuity, and longer axial length compared with those in the healthy controls.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of anterior segment parameters in patients with pseudoexfoliation syndrome using Scheimpflug imaging

Güneş¹,

Yigit²,

Tök³

et al. 2016

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

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“…И ни в одном из них не оценивались такие показатели, как распростра-нённость дендритических клеток и гиперрефлек-тивных межклеточных микровключений, выра-женность очагов десквамации поверхностного эпителия и уплотнения боуменовой мембраны. Martone et al указали на единичный случай на-личия дендритических клеток и гиперрефлектив-ных межклеточных микровключений при ПЭС [23]. Несколько авторов отметили возможность визуализации ПЭМ на эндотелии роговицы при помощи конфокальной микроскопии [12,24,25].…”

Section: Discussionunclassified

The influence of pseudoexfoliative syndrome on corneal morphology based on in vivo confocal microscopy

Потемкин

Витальевич²,

Varganova

et al. 2017

Ophthalmology Reports

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 Конфокальная микроскопия -современный метод исследования, позволяющий в режиме реального времени оценить неинвазивно in vivo структуру роговицы, лимба и конъюнктивы. Цель -оценить основные морфологические изменения роговицы, наблюдаемые при конфокальной микроскопии у пациентов с псевдоэксфолиативным синдромом (ПЭС). Материалы и методы. Был обследован 21 пациент. Основную группу составили 12 пациентов с ПЭС, группу контроля -9 пациентов без ПЭС. Результаты. У пациентов с ПЭС наблюдалось снижение плотности клеток эпителия и стромы роговицы, большое количество гиперрефлективных межклеточных микровключений и дендритических клеток (p < 0,05). Ключевые слова: конфокальная микроскопия; псевдоэксфолиативный синдром.  Confocal microscopy is a modern examination method, which provides in real-time mode a noninvasive in vivo imaging of the cornea, limb, and conjunctiva. Purpose. To evaluate main morphological changes observed by confocal microscopy in patients with pseudoexfoliation (PEX) syndrome. Methods. 21 patients were examined. 12 patients with PEX syndrome were enrolled as the main group, and 9 patients without PEX -as controls. Results. In patients with PEX, there was a decreased cell density in the epithelium and the stroma of the cornea, as well as a lot of hyperreflective intercellular microdeposits and dendritic cells (p < 0.05). THE INFLUENCE OF PSEUDOEXFOLIATIVE SYNDROME ON CORNEAL MORPHOLOGY BASED ON IN VIVO CONFOCAL MICROSCOPY Key words: confocal microscopy; pseudoexfoliation syndrome. ВВЕДЕНИЕПсевдоэксфолиативный синдром (ПЭС) -системное, ассоциированное с возрастом забо-левание, для которого характерна продукция и накопление внеклеточного амилоидподобного материала [3,[5][6][7]. ПЭС поражает множество тканей и органов, но именно офтальмологиче-ские проявления являются основой для поста-новки диагноза [3,4,6]. Это возможно благо-даря тому, что рутинного биомикроскопического исследования достаточно для обнаружения псев-доэксфолиативного материала (ПЭМ). Типичным

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“…A few studies in the literature have used in vivo corneal confocal microscopy to study the corneas of patients with PEX. Martone et al detected hyperreflective deposits and den dritic cells infiltrating the basal epithelial cell layer in one case using in vivo corneal confocal microscopy (7) . They also found fibrillar subepithelial structures, and the endothelial layer showed cellular anomalies.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have described the changes in the histopathological endothelial characteristics (3,7,12) , although few used in vivo cor neal confocal microscopy to analyze the possible differences between patients with and without PEX. Zheng et al observed not only lower endothelial cell density but also increased degrees of pleomorphism and polymegathism and a higher coefficient of variation in the cell sizes in the patients with PEX compared with those in the healthy control subjects (3) .…”

Section: Discussionmentioning

confidence: 99%