Pseudoangiosarcomatous squamous cell carcinoma: first case report on penis

Barbosa, Liseana O; Neto, José Osvaldo Barbosa; Teixeira-Júnior, Antonio; Nogueira, Leudivan Ribeiro; Calixto, José de Ribamar Rodrigues; Cunha, Isabela; Pinho, Jaqueline Diniz; Nascimento, Francisco Sérgio Moura Silva do; Melo, Syomara Pereira da Costa; Soares, Fernando Augusto; Silva, Gyl Eanes Barros

doi:10.21037/tau-20-1234

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…In our series, when we searched for tumors that were negative for koilocytosis, HPV infection, and p16 INK4a overexpression, only one case was not positive for any of these three parameters. Interestingly, this was the first case report of pseudoangiosarcomatous squamous cell carcinoma on the penis, an uncommon and highly aggressive variant of squamous cell carcinoma [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease

et al. 2022

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Background Although penile cancer (PC) is uncommon in developed countries, it is widespread in developing countries. The state of Maranhão (Northeast, Brazil) has the highest global incidence recorded for PC, and, despite its socioeconomic vulnerability, it has been attributed to human papillomavirus (HPV) infection. This study aimed to determine the histopathological features, the prevalence of HPV infection, and the immunohistochemical profile of PC in Maranhão. Methods A retrospective cohort of 200 PC cases were evaluated. HPV detection was performed using nested-PCR followed by direct sequencing for genotyping. Immunohistochemistry (IHC) was performed using monoclonal antibodies anti-p16INK4a, p53, and ki-67. Results Our data revealed a delay of 17 months in diagnosis, a high rate of penile amputation (96.5%), and HPV infection (80.5%) in patients from Maranhão (Molecular detection). We demonstrated the high rate of HPV in PC also by histopathological and IHC analysis. Most patients presented koilocytosis (75.5%), which was associated with those reporting more than 10 different sexual partners during their lifetime (p = 0.001). IHC revealed frequent p16INK4a overexpression (26.0%) associated with basaloid (p < 0.001) and high-grade tumors (p = 0.008). Interestingly, p16 appears not to be a better prognostic factor in our disease-free survival analysis, as previously reported. We also demonstrated high ki-67 and p53 expression in a subset of cases, which was related to worse prognostic factors such as high-grade tumors, angiolymphatic and perineural invasion, and lymph node metastasis. We found a significant impact of high ki-67 (p = 0.002, log-rank) and p53 (p = 0.032, log-rank) expression on decreasing patients’ survival, as well as grade, pT, stage, pattern, and depth of invasion (p < 0.05, log-rank). Conclusions Our data reaffirmed the high incidence of HPV infection in PC cases from Maranhão and offer new insights into potential factors that may contribute to the high PC incidence in the region. We highlighted the possible association of HPV with worse clinical prognosis factors, differently from what was observed in other regions. Furthermore, our IHC analysis reinforces p16, ki-67, and p53 expression as important diagnosis and/or prognosis biomarkers, potentially used in the clinical setting in emerging countries such as Brazil.

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Section: Discussionmentioning

confidence: 99%

A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease

et al. 2022

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“…Pseudoangiosarcoma squamous cell carcinoma (PAS-CC) is a rare type of squamous cell carcinoma that is prone to recurrence and metastasis (1). The lack of pathological diagnosis and standardized clinical treatment plan are the important factors affecting the poor prognosis (2).…”

Section: Introductionmentioning

confidence: 99%

“…According to the World Health Organization (WHO), PASCC (also known as pseudoangiomatoid or pseudovascular adenoid SCC) is an uncommon original disease entity and a highly aggressive variant of SCC (1)(2)(3). The disease was first introduced by Nappi et al in 1992 (4).…”

Section: Introductionmentioning

confidence: 99%

Pseudoangiosarcomatous squamous cell carcinoma: a rare subtype of squamous cell carcinoma that needs to be differentiated from angiosarcoma and has a poor prognosis

Zhan¹,

Wan²,

Wu³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Clinical, Dermoscopic, and Molecular Features of Acantholytic Squamous Cell Carcinoma: A Systematic Review

Zhu,

Mija,

Conte

et al. 2024

Cancers

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Introduction: Acantholytic squamous cell carcinoma (aSCC) is a rare clinicopathological subtype of cutaneous squamous cell carcinoma, accounting for approximately 4.9% of all SCC cases. However, there are currently no standardized criteria for the diagnosis of aSCC. This systematic review is the first to summarize the clinical and molecular features of aSCC. Methods: A systematic search of Medline, Embase, Scopus, and PubMed was performed. All articles in English or French were included, with no restriction of publication date. All articles with original data pertaining to clinical or molecular characteristics of aSCC were included. Two reviewers screened articles and resolved conflicts. Results: Our systematic review included 52 studies on the clinical and molecular features of aSCC, including a total of 482 patients (76% male, mean age at diagnosis 68.9 years): 430 cases assessed clinical features, while 149 cases assessed molecular features. The most common location of aSCC was the head and neck (n = 329/430; 76.5%). In terms of morphology, most lesions were described as nodules (n = 93/430, 21.6%), with common surface changes being hyperkeratosis (n = 6), erosion (n = 6), ulceration (n = 5), and crusting (n = 3). With regard to dermoscopy, only six cases were noted in the literature, including findings such as ulceration (n = 3), keratin clots (n = 2), and erosions (n = 2). Thirty-four studies discussed the molecular markers of aSCC, with the most prevalent markers being cytokeratins. CD15 negativity was noted in 23 cases, while common endothelial vascular markers such as CD34 (n = 16), CD31 (n = 15), factor VIII-related antigen (n = 10), and ERG (n = 1) were often not expressed. Finally, expression of intracellular adhesion molecules (i.e., E-cadherin, CD138) was markedly decreased compared to non-acantholytic invasive SCC. Conclusions: This systematic review summarizes the clinical characteristics and molecular features of aSCC. As clinical differentiation can be difficult, clinicopathological correlation with molecular markers may help ensure proper diagnosis.

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Pseudoangiosarcomatous squamous cell carcinoma: first case report on penis

Cited by 3 publications

References 8 publications

A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease

A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease

Pseudoangiosarcomatous squamous cell carcinoma: a rare subtype of squamous cell carcinoma that needs to be differentiated from angiosarcoma and has a poor prognosis

Clinical, Dermoscopic, and Molecular Features of Acantholytic Squamous Cell Carcinoma: A Systematic Review

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