Prussian blue nanoparticles operate as a new generation of photothermal ablation agents for cancer therapy

Fu, Gengtao; Liu, Wei; Feng, Shouhua; Yue, Xiuli

doi:10.1039/c2cc36456e

Cited by 296 publications

(263 citation statements)

References 18 publications

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“…A solid-state NIR laser (Ocean Optics), which emits light, (785 nm, 500 mW) was guided through an optical fiber the end of which was placed at 2 cm over the liquid/air interface. The temperature was measured using a TES 1326S/1327K infrared thermometer after irradiation pulses (Hong et al 2011;Fu et al 2012).…”

Section: Synthesis and Characterization Of Pani-npsmentioning

confidence: 99%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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Polyaniline nanoparticles (PANI-Nps) have been used in several applications; however, there are few publications related to the use in the photothermal therapy. PANI-Nps have high optical absorbance in the near-infrared region and in this wavelength range, biological systems are relatively transparent. For this reason, these materials can be used to absorb energy and to generate heat that destroys cancer cells selectively. PANI-Nps with average size of ca. 200 nm and neutral zeta potential were synthesized and characterized by DLS, SEM, and zeta potential. The kinetics of incorporation of PANINps into LM2 cell line was monitored using UV-Vis spectrophotometry. The analysis of cell viability after PANI-Nps exposure shows that these nanoparticles are not cytotoxic even at high concentration and show no change in cell morphology and metabolic activity. Furthermore, we found that nanoparticle cell uptake reaches the maximum value c.a. 3 h after incubation. Cells were targeted by Pani-Nps and irradiated, resulting in significant elevation of intracellular ROS and heat production. One of the mechanisms of PANINps-mediated photothermal killing of cancer cells apparently involved oxidative stress resulting in apoptotic cell death.

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Section: Synthesis and Characterization Of Pani-npsmentioning

confidence: 99%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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“…Prussian blue (PB), which has been approved by FDA for the treatment of radioactive exposure in the clinic, has also been investigated as a photothermal agent by several groups including ours [73][74][75]. In our latest work [74], PEGylated PB nanocubes (PB-PEG NCs) were fabricated and i.v.…”

Section: Other Organic Ptt Agentsmentioning

confidence: 99%

Recent advances in the development of organic photothermal nano-agents

2014

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Recently, photothermal therapy (PTT) has attracted tremendous attention because of its high efficacy in tumor ablation and minimal damage to normal tissues. While many inorganic nanomaterials, especially various gold nanostructures and nanocarbons, have been extensively explored for near-infrared (NIR) light triggered PTT in the past decade, a variety of organic photothermal agents have also emerged in recent years, aiming at replacing their inorganic counterparts which usually are not biodegradable. In this mini-review, we will summarize several typical classes of recently developed NIR-absorbing organic PTT nanoagents, which include NIR dye-containing micelles, porphysomes, protein-based agents, conjugated polymers, and organic/inorganic nanocomposites. The development of imaging-guided PTT and combination therapy will be introduced as well. Finally, the perspectives and challenges in the future development of PTT will be discussed.

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“…[19][20][21][22] These PB and analogue micro/nanostructures show intriguing size-or shape-dependent magnetism, [23,24] optics, [25,26] gas storage, [17,18] and electrochemistry properties. [27,28] Despite the wide variety of morphologies and properties afforded by the PB family, little attention has been paid to micro/nanoscale objects made of octacyanometalate-based CPs. This is partly due to significant difficulties in their synthesis, because the complex molecular structure and changeful coordination modes cause uncertainty in the structures of the final CP products.…”

Section: Introductionmentioning

confidence: 99%

Shape and Size Tunable Synthesis of Coordination Polymer Mn₂W(CN)₈·xH₂O Microcrystals through a Simple Solution Chemical Route

et al. 2013

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Along with reduced graphene oxide (RGO), water soluble Prussian blue nanoparticles (PBNPs, around 6 nm) are synthesized and broadly characterized. These two types of highly stable, low‐cost and chemically compatible nanomaterials are exploited as building ingredients to prepare electrically enhanced and functionally endorsed nanohybrid electrocatalysts, which are further transformed into free‐standing graphene papers. PBNPs doped graphene papers show highly efficient electrocatalysis towards reduction of hydrogen peroxide and can be used alone as flexible chemical sensors for potential applications in detection of hydrogen peroxide or/and other organic peroxides. The as‐prepared PBNPs–RGO papers are further capable of biocompatible accommodation of enzymes for development of free‐standing enzyme based biosensors. In this regard, glucose oxidase is used as an example for electrocatalytic oxidation and detection of glucose. The present work demonstrates a facile and highly reproducible way to construct free‐standing and flexible graphene paper doped with electroactive catalyst. Thanks to high stability, low‐cost and efficient electrocatalytic characteristics, this kind of nanohybrid material has potential to be produced on a large scale, and offers a broad range of possible applications, particularly in the fabrication of flexible sensing devices and as a platform for electrocatalytic energy conversion.

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Prussian blue nanoparticles operate as a new generation of photothermal ablation agents for cancer therapy

Cited by 296 publications

References 18 publications

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Recent advances in the development of organic photothermal nano-agents

Shape and Size Tunable Synthesis of Coordination Polymer Mn₂W(CN)₈·xH₂O Microcrystals through a Simple Solution Chemical Route

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Prussian blue nanoparticles operate as a new generation of photothermal ablation agents for cancer therapy

Cited by 296 publications

References 18 publications

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Recent advances in the development of organic photothermal nano-agents

Shape and Size Tunable Synthesis of Coordination Polymer Mn2W(CN)8·xH2O Microcrystals through a Simple Solution Chemical Route

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Shape and Size Tunable Synthesis of Coordination Polymer Mn₂W(CN)₈·xH₂O Microcrystals through a Simple Solution Chemical Route