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The development of a simple and reproducible route to prepare uniform core@TiO(2) structures is urgent for realizing multifunctional responses and harnessing multiple interfaces for new or enhanced functionalities. Here, we report a versatile kinetics-controlled coating method to construct uniform porous TiO(2) shells for multifunctional core-shell structures. By simply controlling the kinetics of hydrolysis and condensation of tetrabutyl titanate (TBOT) in ethanol/ammonia mixtures, uniform porous TiO(2) shell core-shell structures can be prepared with variable diameter, geometry, and composition as a core (e.g., α-Fe(2)O(3) ellipsoids, Fe(3)O(4) spheres, SiO(2) spheres, graphene oxide nanosheets, and carbon nanospheres). This method is very simple and reproducible, yet important, which allows an easy control over the thickness of TiO(2) shells from 0 to ~25, ~45, and ~70 nm. Moreover, the TiO(2) shells possess large mesoporosities and a uniform pore size of ~2.5 nm, and can be easily crystallized into anatase phase without changing the uniform core-shell structures.

The rational design and controllable synthesis of strongly coupled inorganic/graphene hybrids represents a long-standing challenge for developing advanced catalysts and energy-storage materials. Here, we report a simple sol-gel method toward creating ultradispersed TiO2 nanoparticles on graphene with an unprecedented degree of control based on the precise separation and manipulation of nanoparticles nucleated, grown, anchored, and crystallized and the reduction of graphene oxide (GO). The hybrid materials show ultradispersed anatase nanoparticles (~5 nm), ultrathin thickness (≤3 layers), and a high surface area of ~229 m(2)/g and exhibit a high specific capacity of ~94 mA h g(-1) at ~59 C, which is twice as that of mechanically mixed composites (~41 mA h g(-1)), demonstrating the potential of strongly synergistic coupling effects for advanced functional systems.

Herein, prussian blue nanoparticles, an ancient dye, were explored as a new generation of near-infrared laser-driven photothermal ablation agents for cancer therapy alternative to traditional agents due to their good photothermal efficiency and high photothermal stability but low cost and particularly clinically approved biosafety.

Aus dem Kokon geschlüpft: Wasserlösliche N‐dotierte Kohlenstoffnanokugeln von ca. 70 nm Größe können in großen Mengen durch einen einfachen hydrothermalen Prozess unter Verwendung von Kokonseide synthetisiert werden. Die Nanokugeln zeigen exzellente Photolumineszenzeigenschaften und sind biokompatibel für einen Einsatz in der In‐vivo‐Bildgebung.

The capabilities of using gold nanoparticle based surface-enhanced Raman spectroscopy (SERS) to obtain blood serum biochemical information for non-invasive colorectal cancer detection were presented in this paper. SERS measurements were performed on two groups of blood serum samples: one group from patients (n = 38) with pathologically confirmed colorectal cancer and the other group from healthy volunteers (control subjects, n = 45). Tentative assignments of the Raman bands in the measured SERS spectra suggested interesting cancer specific biomolecular changes, including an increase in the relative amounts of nucleic acid, a decrease in the percentage of saccharide and proteins contents in the blood serum of colorectal cancer patients as compared to that of healthy subjects. Both empirical approach and multivariate statistical techniques, including principal components analysis (PCA) and linear discriminant analysis (LDA) were employed to develop effective diagnostic algorithms for classification of SERS spectra between normal and colorectal cancer serum. The empirical diagnostic algorithm based on the ratio of the SERS peak intensity at 725 cm(-1) for adenine to the peak intensity at 638 cm(-1) for tyrosine achieved a diagnostic sensitivity of 68.4% and specificity of 95.6%, whereas the diagnostic algorithms based on PCA-LDA yielded a diagnostic sensitivity of 97.4% and specificity of 100% for separating cancerous samples from normal samples. Receiver operating characteristic (ROC) curves further confirmed the effectiveness of the diagnostic algorithm based on PCA-LDA technique. The results from this exploratory study demonstrated that gold nanoparticle based SERS serum analysis combined with PCA-LDA has tremendous potential for the non-invasive detection of colorectal cancers.

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