PRP-chitosan thermoresponsive hydrogel combined with black phosphorus nanosheets as injectable biomaterial for biotherapy and phototherapy treatment of rheumatoid arthritis

Pan, Wenzhen; Dai, Chengbai; Li, Yang; Yin, Yiming; Gong, Li; Machuki, Jeremiah Ong’achwa; Yang, Yun; Qiu, Shang; Guo, Kaijin; Gao, Fenglei

doi:10.1016/j.biomaterials.2020.119851

Cited by 133 publications

(96 citation statements)

References 57 publications

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“…In recent years, NIR light-assisted phototherapy has been recognized as a promising strategy, not only for anticancer therapy, but also for antibacterial and anti‑inflammation therapies 15 , 58 , 83 . The NIR light-responsive nanomaterials could be coated onto the bone implants, exhibiting outstanding photothermal and photodynamic therapeutic effects to destroy bacterial integrity or biofilm structure via hyperthermia and ROS generation 16 .…”

Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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“…By introducing BP nanosheets, CaP (calcium phosphate) crystal formation and excellent mechanical properties were induced, and concurrent osteogenic differentiation of osteoblasts provided a favorable ECM microenvironment to promote the repair and regeneration of defective bone. Pan et al combined BP nanosheets into a platelet rich plasma (PRP) chitosan thermal response hydrogel for the treatment of arthritis and bone defects caused by rheumatoid arthritis (RA) [ 157 ]. The local heat generated by BP under NIR and the generated reactive oxygen species (ROS) are transferred to the diseased joint to remove the proliferative synovial tissue, meanwhile, the release of BP degradation products can be precisely controlled, providing sufficient raw materials for osteogenesis, and promoting the repair of bone defects caused by RA.…”

Section: Application Of Bp- Based Hydrogel In Bone Regenerationmentioning

confidence: 99%

Black phosphorus-based 2D materials for bone therapy

Cheng

Cai

Zhao

et al. 2020

Bioactive Materials

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Since their discovery, Black Phosphorus (BP)-based nanomaterials have received extensive attentions in the fields of electromechanics, optics and biomedicine, due to their remarkable properties and excellent biocompatibility. The most essential feature of BP is that it is composed of a single phosphorus element, which has a high degree of homology with the inorganic components of natural bone, therefore it has a full advantage in the treatment of bone defects. This review will first introduce the source, physicochemical properties, and degradation products of BP, then introduce the remodeling process of bone, and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels, polymer membranes, microspheres, and three-dimensional (3D) printed scaffolds. Finally, we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application.

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“…After NIR irradiation, these photonic nanoagents achieve photothermal-energy conversion to generate hyperthermia effect. Meanwhile, cytotoxic ROS is generated at the inflammation site to promote the apoptosis of target cells (Gulzar et al, 2018 ; Pan et al, 2020 ). In addition to excellent photonic-therapeutic effect, CuS NPs and BPNs are conducive to alleviate cartilage and bone erosion caused by RA (Lu et al, 2018a , b ; Pan et al, 2020 ).…”

Section: Photo-based Energy-conversion Nanotherapy For Ra Treatmentmentioning

confidence: 99%

“…Meanwhile, cytotoxic ROS is generated at the inflammation site to promote the apoptosis of target cells (Gulzar et al, 2018 ; Pan et al, 2020 ). In addition to excellent photonic-therapeutic effect, CuS NPs and BPNs are conducive to alleviate cartilage and bone erosion caused by RA (Lu et al, 2018a , b ; Pan et al, 2020 ). Nanoparticles with bone protection ability can greatly avoid the deformity and disability of joints in advanced RA patients, which effectively ameliorate their life quality.…”

Section: Photo-based Energy-conversion Nanotherapy For Ra Treatmentmentioning

confidence: 99%

“…Analog to Cu 7.2 S 4 nanoparticles, black phosphorus nanosheets (BPNs) exert profound photo-therapeutic effects in RA treatment based on both PTT and PDT effects. Pan et al ( 2020 ) integrated BPNs with heat-sensitive chitosan nanogels containing platelet-rich plasma (PRP) to construct heat-responsive nanocomposites for intra-articular treatment of RA. Unlike chitosan nanogels for PDT developed by Schmitt et al ( 2010 ), BPNs gave BPNs/Chitosan/PRP thermosensitive hydrogel better photonic-therapeutic effect (a 43.19% photothermal conversion efficiency and excellent ROS generation capacity) to excise RA proliferating synoviocytes.…”

Section: Photo-based Energy-conversion Nanotherapy For Ra Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment

Wang

et al. 2020

Front. Bioeng. Biotechnol.

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Rheumatoid arthritis (RA) is characterized by synovial hyperplasia and cartilage/bone destruction, which results in a high disability rate on human health and a huge burden on social economy. At present, traditional therapies based on drug therapy still cannot cure RA, in accompany with the potential serious side effects. Based on the development of nanobiotechnology and nanomedicine, energy conversion-based nanotherapy has demonstrated distinctive potential and performance in RA treatment. This strategy employs specific nanoparticles with intrinsic physiochemical properties to target lesions with the following activation by diverse external stimuli, such as light, ultrasound, microwave, and radiation. These nanoagents subsequently produce therapeutic effects or release therapeutic factors to promote necrotic apoptosis of RA inflammatory cells, reduce the concentration of related inflammatory factors, relieve the symptoms of RA, which are expected to ultimately improve the life quality of RA patients. This review highlights and discusses the versatile biomedical applications of energy conversion-based nanotherapy in efficient RA treatment, in together with the deep clarification of the facing challenges and further prospects on the final clinical translations of these energy conversion-based nanotherapies against RA.

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PRP-chitosan thermoresponsive hydrogel combined with black phosphorus nanosheets as injectable biomaterial for biotherapy and phototherapy treatment of rheumatoid arthritis

Cited by 133 publications

References 57 publications

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Black phosphorus-based 2D materials for bone therapy

Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment

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