PRP and Articular Cartilage: A Clinical Update

Marmotti, Antonio; Rossi, Roberto; Castoldi, Filippo; Roveda, Eliana; Michielon, Gianni; Peretti, Giuseppe M.

doi:10.1155/2015/542502

Cited by 92 publications

(66 citation statements)

References 110 publications

(130 reference statements)

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“…[33] In the advanced stages of OA, PRP might not have a direct effect on the chondrocyte anabolic process, but an anti-inflammatory effect through the regulation of joint homeostasis and the cytokine level. [29,34] However, contrary to this opinion, Calis et al showed that PRP administered three times at weekly intervals to patients with grade 3 and 4 knee OA reported improvements in their quality of life, and reduced levels of pain, and had increased cartilage thickness as measured by ultrasonography at the 6-month follow up. [35] To a lesser extent patient selections parameters such as gender and BMI should be considered, with females and high BMI being associated with worse outcomes.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Platelet-Rich Plasma in the Treatment of Moderate Knee Osteoarthritis

Munde¹,

Jha²,

Malik³

2017

Ann. Int. Med. Den. Res.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Platelet-Rich Plasma in the Treatment of Moderate Knee Osteoarthritis

Munde¹,

Jha²,

Malik³

2017

Ann. Int. Med. Den. Res.

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“…Plateletrich plasma has emerged as a promising augmentation method given its positive healing effects in degenerative knee pathologies. 28 However, more studies are needed to elucidate the effects of platelet-rich plasma augmentation on BMAC effectiveness.…”

Section: Bone Marrow Aspirate Concentrate Techniquementioning

confidence: 99%

Bone Marrow Aspirate Concentrate Harvesting and Processing Technique

Chahla

Mannava

Cinque

et al. 2017

Arthroscopy Techniques

129

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Bone marrow obtained by iliac crest aspiration is a common source for harvesting mesenchymal stem cells, other progenitor cells, and associated cytokine/growth factors. Recent studies have reported good to excellent outcomes with the use of bone marrow aspirate concentrate (BMAC) for pain relief in the treatment of focal chondral lesions and osteoarthritis of the knee. However, the harvesting and processing technique are crucial to achieve satisfactory results. Several studies have examined outcomes after BMAC injection, with encouraging results, but there is a lack of consensus in terms of the frequency of injection, the amount of BMAC that is injected, and the timing of BMAC injections. The purpose of this Technical Note was to describe a standardized bone marrow aspiration harvesting technique and processing method. Bone marrow obtained by iliac crest aspiration is a common source for harvesting mesenchymal stem cells, other progenitor cells, and associated cytokine/ growth factors. Because the use of bone marrow aspirate concentrate (BMAC) is currently approved by the United States Food and Drug Administration, it represents one of the few means for acquiring progenitor cells and growth factors for subsequent injection.

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“…In advanced OA stages, PRP may not affect the anabolic process of chondrocyte directly, but it regulates joint homeostasis and the cytokine level thus it has an anti-inflammatory effect (24).…”

Section: Discussionmentioning

confidence: 99%

Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis

2017

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Objective: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended to clarify the effect of PRP on the functional status of the osteoarthritic knee joint. Material and Methods:Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according to Kellgren-Lawrence grading scale (KL) into (Group Ι): including patients with KL grade < 3 and (Group ΙΙ): including patients with KL grade ≥3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was prepared and injected immediately into the affected knee. Serum Coll2-1 (S.Coll2-1) concentration was measured by enzyme-linked immunosorbent assay (ELISA) kit pre and 3 months after PRP injection.Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p<0.001) and (p<0.05) in group Ι and group ΙΙ respectively as well as significant improvements in WOMAC total and WOMAC sub-scores values were noted after single intra-articular PRP injection with maximal functional improvements were achieved after 3 months (p<0.001). Mild cases experienced favorable results with no remarkable adverse reactions were observed. Conclusion:Reduction in specific OA biomarker S.Coll2-1 following intra-articular PRP injection emphasize that PRP could be a promising safe and tolerable effective therapeutic option which improves function from basal states in primary knee OA patients.

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PRP and Articular Cartilage: A Clinical Update

Cited by 92 publications

References 110 publications

Effectiveness of Platelet-Rich Plasma in the Treatment of Moderate Knee Osteoarthritis

Effectiveness of Platelet-Rich Plasma in the Treatment of Moderate Knee Osteoarthritis

Bone Marrow Aspirate Concentrate Harvesting and Processing Technique

Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis

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