Effectiveness of Platelet-Rich Plasma in the Treatment of Moderate Knee Osteoarthritis

A comparative study of 60 patients to compare the efficacy of P-PRP (Pure-platelet rich plasma) v/s hyaluronic acid injection in treatment of osteoarthritis of knee

“…The improvement in pain was significantly better in Group A when compared to Group B after 4 weeks, 12 weeks and 24 weeks as per ANOVA test (p<0.05). This is comparable to the studies of Lana JFSD et al [49] , Munde SL et al [38] , Sampson S et al [32] , Kon E et al [20] and Raeissadat SA et al [37] In the advanced stages of OA, PRP might not have a direct effect on the chondrocyte anabolic process, but an antiinflammatory effect through the regulation of joint homeostasis and the cytokine level [20,50] . Calis HT et al [51] study showed that PRP administered three times at weekly intervals to patients with grade 3 and 4 knee OA reported improvements in their quality of life, and reduced levels of pain, and had increased cartilage thickness as measured by ultrasonography at the 6-month follow up.…”

“…Calis HT et al [51] study showed that PRP administered three times at weekly intervals to patients with grade 3 and 4 knee OA reported improvements in their quality of life, and reduced levels of pain, and had increased cartilage thickness as measured by ultrasonography at the 6-month follow up. [38] , Lana JFSD et al [49] , Sanchez M et al [52] , Raeissadat SA et al [37] , Spakova T et al [34] , Kon E et al [33] and Patel S et al [53] . Thus according to VAS score initial results may appear superior for hyalonuric acid but on long term the results of prp are superior and in terms of WOMAC score prp is superior throughout.…”