Provisional evidence that the arginine vasopressin 1a receptor gene is associated with musical memory

Granot, Roni; Frankel, Yoav; Gritsenko, Vladimir; Lerer, Elad; Gritsenko, Inga; Bachner‐Melman, Rachel; Israel, Salomon; Ebstein, Richard P.

doi:10.1016/j.evolhumbehav.2007.05.003

Cited by 46 publications

(66 citation statements)

References 29 publications

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“…Because also vasopressin has strong connections with sociality [59], spatial and social memory [60,61], as well as with higher cognitive functions such as memory and learning in humans and other mammals [62], a series of studies started to investigate the role of vasopressin also in human music and dance. Such a coalition has been reported in several studies: the gene responsible for vasopressin receptor, AVPR1a, was associated with the dance phenotype [63], musical short-term memory [64], musical skills [65], and lifelong active listening to music [66]. Similarly, intranasal administration of vasopressin increased musical short-term memory performances [67].…”

Section: Vasopressin Courtship and Musicmentioning

confidence: 83%

Sexual arousal and rhythmic synchronization: A possible effect of vasopressin

Miani

2016

Medical Hypotheses

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Section: Vasopressin Courtship and Musicmentioning

confidence: 83%

Sexual arousal and rhythmic synchronization: A possible effect of vasopressin

Miani

2016

Medical Hypotheses

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“…Morley and colleagues investigated the AVPR1A and SLC6A4 polymorphisms that were previously associated with musical abilities [60,72] (but see [62] for non-replication) and creative dancing [58], testing for their association with choir participation in 523 subjects [61]. Significant association was detected for a SLC6A4 polymorphism but not found for AVPR1A haplotypes proposed to be connected with musical skills in other studies.…”

Section: Genetic Contributions To Individual Differences In the Genermentioning

confidence: 99%

“…The choice of candidate genes has been motivated by prior studies outside the music domain; for example, some studies of musical memory have targeted arginine vasopressin receptor 1a (AVPR1A) and serotonin transporter (SLC6A4) genes, because common polymorphisms of those genes had been previously reported to be associated with creative dance performance [58]. A study of musical and phonological memory in 82 students found provisional evidence that these skills were associated with a gene Â gene epistatic interaction between promoter region polymorphisms of the two candidate genes [72]. In a follow-up to this work, intranasal administration of the arginine vasopressin hormone in 25 males was reported to affect musical working memory as well as mood and attentiveness levels, without influencing digit span test scores, suggesting a complex interaction between this hormone, musical memory and affective states [73].…”

Section: Genetic Contributions To Individual Differences In the Genermentioning

confidence: 99%

Defining the biological bases of individual differences in musicality

Gingras

Honing

Peretz

et al. 2015

Phil. Trans. R. Soc. B

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One contribution of 12 to a theme issue 'Biology, cognition and origins of musicality'. Advances in molecular technologies make it possible to pinpoint genomic factors associated with complex human traits. For cognition and behaviour, identification of underlying genes provides new entry points for deciphering the key neurobiological pathways. In the past decade, the search for genetic correlates of musicality has gained traction. Reports have documented familial clustering for different extremes of ability, including amusia and absolute pitch (AP), with twin studies demonstrating high heritability for some music-related skills, such as pitch perception. Certain chromosomal regions have been linked to AP and musical aptitude, while individual candidate genes have been investigated in relation to aptitude and creativity. Most recently, researchers in this field started performing genome-wide association scans. Thus far, studies have been hampered by relatively small sample sizes and limitations in defining components of musicality, including an emphasis on skills that can only be assessed in trained musicians. With opportunities to administer standardized aptitude tests online, systematic large-scale assessment of musical abilities is now feasible, an important step towards high-powered genome-wide screens. Here, we offer a synthesis of existing literatures and outline concrete suggestions for the development of comprehensive operational tools for the analysis of musical phenotypes.

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“…Genomic DNA was extracted from peripheral blood with standard phenol-chloroform procedure. Genotyping of the highly variable microsatellites RS3 (corresponding to (CT) 4 -TT-(CT) 8 (GT) 24 ) and RS1 (corresponding to (GATA) 14 ) residing in the promoter region and AVR (corresponding to (GT) 14 (GA) 13 (A) 8 ) microsatellite in the intron of the AVPR1A gene was performed ( Figure 2). 22 The SLC6A4 promoter region 5-HTTLPR and the VNTR microsatellite were genotyped as described by Ukkola et al 8 Primer sequences are available on request from the authors.…”

Section: Laboratory Proceduresmentioning

confidence: 99%

“…11-12 SLC6A4 together with AVPR1A polymorphisms have been reported to associate with artistic creativity in professional dancers 13 and with short-term musical memory. 14 The human serotonin transporter (SLC6A4; 5-HTT) is expressed in the brain, mainly in the areas involved with emotions in the cortex and limbic systems. SLC6A4 removes serotonin released into the synaptic cleft and has been shown to affect amygdala activation.…”

Section: Introductionmentioning

confidence: 99%

Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music

et al. 2011

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Music is listened in all cultures. We hypothesize that willingness to produce and perceive sound and music is social communication that needs musical aptitude. Here, listening to music was surveyed using a web-based questionnaire and musical aptitude using the auditory structuring ability test (Karma Music test) and Carl Seashores tests for pitch and for time. Three highly polymorphic microsatellite markers (RS3, RS1 and AVR) of the arginine vasopressin receptor 1A (AVPR1A) gene, previously associated with social communication and attachment, were genotyped and analyzed in 31 Finnish families (n¼437 members) using family-based association analysis. A positive association between the AVPR1A haplotype (RS1 and AVR) and active current listening to music (permuted P¼0.0019) was observed. Other AVPR1A haplotype (RS3 and AVR) showed association with lifelong active listening to music (permuted P¼0.0022). In addition to AVPR1A, two polymorphisms (5-HTTLPR and variable number of tandem repeat) of human serotonin transporter gene (SLC6A4), a candidate gene for many neuropsychiatric disorders and previously associated with emotional processing, were analyzed. No association between listening to music and the polymorphisms of SLC6A4 were detected. The results suggest that willingness to listen to music is related to neurobiological pathways affecting social affiliation and communication.

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Provisional evidence that the arginine vasopressin 1a receptor gene is associated with musical memory

Cited by 46 publications

References 29 publications

Sexual arousal and rhythmic synchronization: A possible effect of vasopressin

Sexual arousal and rhythmic synchronization: A possible effect of vasopressin

Defining the biological bases of individual differences in musicality

Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music

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