Providencia alcalifaciens strains translocate from the gastrointestinal tract and are resistant to lytic activity of serum complement

Vieira, Antonia Benedita Rodrigues; Koh, Ivan Hong Jun; Guth, Beatriz E. C.

doi:10.1099/jmm.0.04993-0

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…This was a significant discovery due to clinical threats caused by this bacterium. P. alcalifaciens can contribute to the development of gastroenteritis in humans and animals (26,27). Bacteriophages active against Providencia spp.…”

Section: Resultsmentioning

confidence: 99%

Isolation of multidrug resistant coliforms and their bacteriophages from swine slurry

Augustyniak¹,

Grygorcewicz²,

Nawrotek³

2018

Turk J Vet Anim Sci

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Slurry management is a contemporary agricultural problem. Although liquid manure is a valuable fertiliser, it may pose a microbiological threat due to spreading of bacteria resistant to various antibiotics. Fermentation has been proposed as a solution to this problem, although it does not fully eliminate the antibiotic-resistant strains. The presence of gram-negative rods resistant to antimicrobials may cause an uncontrolled transmission of resistance factors and genes in the natural environment. Therefore, a biocontrol system is necessary to prevent this phenomenon. The aim of this study was to detect multidrug-resistant (MDR) bacteria and their lytic bacteriophages in raw swine slurry. For that purpose, MDR bacteria from the family Enterobacteriaceae were isolated and tested with bacteriophages using a modified detection method. The study suggests that the bacteriophages present in the slurry are active against MDR bacteria and possibly could be used as a biocontrol agent for reduction of these microorganisms in fertilisers of animal origin. In the scope of the results obtained, a novel approach for the evaluation of slurry based on the preselection method is proposed. Moreover, the study reports the first case of isolation of a bacteriophage active against Providencia alcalifaciens.

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Section: Resultsmentioning

confidence: 99%

Isolation of multidrug resistant coliforms and their bacteriophages from swine slurry

Augustyniak¹,

Grygorcewicz²,

Nawrotek³

2018

Turk J Vet Anim Sci

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“…Interstitial broadening and massive inflammatory cells infiltrated can be seen in histologic sections. However, Vieira et al 22 also demonstrated the ability of P. alcalifaciens to translocate from the intestinal lumen to extraintestinal sites of the host using a small animal model. It was observed that both invasive and noninvasive P. alcalifaciens strains isolated from diarrheal patients were able to resist the human serum bactericidal activity and exhibited the ability to translocate from the gastrointestinal tract to mesenteric lymph nodes, liver, and spleen, which supports the potential role in causing disseminated infection.…”

Section: Clinical Features and Diagnosismentioning

confidence: 99%

Epidemiology and Pathogenesis of Providencia alcalifaciens Infections

Shah

Odoyo

Ichinose

2019

The American Journal of Tropical Medicine and Hygiene

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Providencia alcalifaciens is a member of the family Enterobacteriaceae that has been commonly implicated as a causative agent of diarrheal infection in humans and animals. Recent outbreaks of P. alcalifaciens in both developing and developed countries have raised public health concerns. Several studies have suggested that P. alcalifaciens can cause diarrhea by invading the intestinal mucosa, although its pathogenicity has not been well established. Often routine laboratory investigations that seek etiological agents of diarrhea do not actively pursue P. alcalifaciens detection. Therefore, routine laboratory diagnosis should be given more attention for better understanding the epidemiology and pathogenicity of P. alcalifaciens.

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“…The current study demonstrated the ability of P. vermicola to translocate from the intestinal lumen to extra intestinal when infected orally, Vieira et al found that P.alcalifaciensis as the Enterobacteriaceae member translocation from the gastrointestinal tract to extra intestinal sites and its ability to resist human serum bactericidal activity. (Vieira et al ., 2003). The histological changes in intestine infiltration of inflammatory cells in mucosa and submucosa layers, hyperplasia of goblet cells, accordance to study, there is partial necrosis of the intestinal villi with complete necrosis of surface epithelium and partial necrosis of colonic crypts in the large intestine in mice infected with P.rettgeri (Al-Janabi, 2012).…”

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confidence: 99%

Study the pathogenicity of Providencia Vermicola in mice

Ameer

Al-Gburi

2022

ijhs

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P. vermicola is an opportunistic pathogen of human and animals. To estimate the pathogeneses of P.vermicola in mice infected orally and I/P with 1x108 CFU/ml).The histopathological changes at 24 hrs showed infiltration of inflammatory cells and apoptosis in hepatocytes in the liver, infiltration of inflammatory cells around a congested blood vessel and interstitial tissue of kidney; lung revealed congestion of blood vessels, infiltration of inflammatory cells and alveolar emphysema; intestine appeared infiltration of mononuclear cells in mucosa layer with hyperplasia of goblet cells. In mice infected I/P, the liver showed infiltration of inflammatory cells in a necrotic area with granulomatous lesion formation, the spleen showed depletion of white pulp. The kidney revealed dilatation of bowman’s space with vacuolation of glomeruli. The intestine appeared infiltration of inflammatory cells in mucosa and submucosa layers with hyperplasia of goblet cells, also, the lung showed infiltration of inflammatory cells in interalveolar septa and alveolar emphysema.

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Providencia alcalifaciens strains translocate from the gastrointestinal tract and are resistant to lytic activity of serum complement

Cited by 7 publications

References 21 publications

Isolation of multidrug resistant coliforms and their bacteriophages from swine slurry

Isolation of multidrug resistant coliforms and their bacteriophages from swine slurry

Epidemiology and Pathogenesis of Providencia alcalifaciens Infections

Study the pathogenicity of Providencia Vermicola in mice

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