Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study

Başoğlu, Harun; Bilgin, Mehmet; Demir, Mustafa M.

doi:10.1016/j.pdpdt.2015.12.010

Cited by 37 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PVT enhanced the antitumor activity in these models by inducing apoptotic tumor vascular endothelial cell death and platelet aggregation. Recently, Basoglu et al formulated PpIX inside magnetoliposomes (MLs) that also contained magnetic nanoparticles (Fe 3 O 4 ) . Hyperthermia induced by local magnetic field (8.947 ± 2%, 50 Hz) reduced the MCF‐7 cell viability to 66% using 350 nM PpIX‐loaded MLs, however, complete cell death was observed when 250 nM PpIX‐loaded MLs were exposed to LED white light for 5 min.…”

Section: Light‐responsive Liposomesmentioning

confidence: 99%

Stimuli‐responsive liposomes for drug delivery

Lee

Thompson

2017

WIREs Nanomed Nanobiotechnol

308

177

View full text Add to dashboard Cite

The ultimate goal of drug delivery is to increase the bioavailability and reduce the toxic side effects of the active pharmaceutical ingredient (API) by releasing at a specific site of action. In the case of antitumor therapy, association of the therapeutic agent with a carrier system can minimize damage to healthy, non-target tissues, while limit systemic release and promoting long circulation to enhance uptake at the cancerous site due to the enhanced permeation and retention effect (EPR). Stimuli-responsive systems have become a promising way to deliver and release payloads in a site-selective manner and carrier systems have been derived from a wide variety of materials, including inorganic nanoparticles, lipids, and polymers that have been imbued with stimuli-sensitive properties to accomplish triggered release. The unique features in the tumor microenvironment can serve as an endogenous stimulus (pH, redox potential, or unique enzymatic activity) or the locus of an applied external stimulus (heat or light) to trigger the controlled release of API. Triggered release is generally based on the principle of membrane destabilization from local defects within bilayer membranes to effect release of liposome-entrapped drugs. This review focuses on the literature appearing between November 2008–February 2016 that reports new developments in stimuli-sensitive liposomal drug delivery strategies using pH change, enzyme transformation, redox reactions, and photochemical mechanisms of activation.

show abstract

Section: Light‐responsive Liposomesmentioning

confidence: 99%

Stimuli‐responsive liposomes for drug delivery

Lee

Thompson

2017

WIREs Nanomed Nanobiotechnol

308

177

View full text Add to dashboard Cite

show abstract

“…PDT comprises a photosensitizer, laser and dioxygen, and each substance is harmless to cells ( 12 ). The rapid development of the photosensitizer and laser irradiation systems has led to PDT gradually becoming a new method used in the treatment of various types of tumor ( 13 ). The biological mechanism of PDT has been fully understood.…”

Section: Discussionmentioning

confidence: 99%

Curative effect of the recent photofrin photodynamic adjuvant treatment on young patients with advanced colorectal cancer

Sun

Liu

2016

Oncology Letters

View full text Add to dashboard Cite

Advanced colorectal cancer has a high mortality rate and conventional treatments have poor therapeutic effects. The aim of the present study was to analyze the recent curative effect and adverse reaction of photofrin photodynamic adjuvant treatment on young patients with advanced colorectal cancer. A total of 23 patients with advanced colorectal cancer who had accepted semiconductor laser photodynamic adjuvant treatment were selected as the observation group. In addition, 30 patients who had accepted concurrent radiotherapy and chemotherapy during the same period served as the control group. The observation group received photofrin (2 mg/kg) intravenously in 100 ml of 5% glucose, followed by the introduction of the endoscopic optical fiber to deliver laser radiation with an intensity of 630 nm wavelength pulse power. After 2 days, necrotic tissues were removed and irradiation of the original or new tumor lesions was performed and necrotic tissues were removed. The total effective rate and survival time was higher and the length of hospital stay was shorter in the observation group in comparison with the control group. The differences were statistically significant (P<0.05). The number of patients in the control and observation groups with symptoms of hematochezia, change in bowel habit, intestinal stimulation and incomplete intestinal obstruction were reduced. Additionally, the reduced ratio of the observation group was significantly increased in comparison with the control group (P<0.05). The adverse reaction rate of the observation group was lower than that of the control group and this difference was also statistically significant (P<0.05). In conclusion, use of photodynamic treatment for young patients with advanced colorectal cancer can effectively improve the clinical symptoms and reduce complications.

show abstract

“…For example, liposomes carrying the photosensitizer chlorin e6 (Ce6) were modified with AuNCs, where the AuNCs inhibited thioredoxin reductase to improve the efficacy of 1 O 2 produced by Ce6 . Liposomes have also been modified with IONPs to provide magnetic targeting capabilities for protoporphyrin delivery . Likewise, MOFs have been conjugated with photosensitizers and nanozymes for two-step PDT in which the nanozymes generate O 2 from H 2 O 2 before photosensitizer radiation converts O 2 to 1 O 2 , overcoming the PDT limiting factor of tumor hypoxia .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Hybrid Nanosystems for Biomedical Applications

et al. 2021

View full text Add to dashboard Cite

Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy at overcoming obstacles not readily surmounted by nonhybridized counterparts. Currently, hybrid nanosystems are implemented for gene therapy, drug delivery, and phototherapy in addition to tissue regeneration, vaccines, antibacterials, biomolecule detection, imaging probes, and theranostics. Though diverse, these nanosystems can be classified according to foundational inorganic/organic components, accessory moieties, and architecture of hybridization. Within this Review, we begin by providing a historical context for the development of biomedical hybrid nanosystems before describing the properties, synthesis, and characterization of their component building blocks. Afterward, we introduce the architectures of hybridization and highlight recent biomedical nanosystem developments by area of application, emphasizing hybrids of distinctive utility and innovation. Finally, we draw attention to ongoing clinical trials before recapping our discussion of hybrid nanosystems and providing a perspective on the future of the field.

show abstract

Protoporphyrin IX-loaded magnetoliposomes as a potential drug delivery system for photodynamic therapy: Fabrication, characterization and in vitro study

Cited by 37 publications

References 30 publications

Stimuli‐responsive liposomes for drug delivery

Stimuli‐responsive liposomes for drug delivery

Curative effect of the recent photofrin photodynamic adjuvant treatment on young patients with advanced colorectal cancer

Hybrid Nanosystems for Biomedical Applications

Contact Info

Product

Resources

About