Prothrombotic gene polymorphisms and plasma factors in young north Indian survivors of acute myocardial infarction

Kaur, Rupinder; Das, Reena; Ahluwalia, Jasmina; Kumar, Rohit; Kk, Talwar

doi:10.1007/s11239-012-0734-6

Cited by 25 publications

(25 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further subgroup analysis based on comparison of the PlA1/A1 versus PlA2/A2 genotype failed to show a significant association ( n = 23,836; OR 1.023, 95% CI 0.877–1.192; p = 0.774) [70]–[72], [81], [82], [86]–[91], [95], [98]–[100], [102]–[104], [106]–[108], [111]–[114], [116], [117], [120], [122], [124], [128] (Figure 3); however, within this analysis, the number of subjects with the PlA2/A2 genotype was small, consisting of 333 cases and 1,504 controls.…”

Section: Resultsmentioning

confidence: 99%

“…For subjects ≤45 years old, carriage of the PlA2 allele produced a pooled OR for MI of 1.205 ( n = 9,547; 95% CI 1.067–1.360; p = 0.003) with significant heterogeneity (I 2 = 70.3%, p<0.001), and analysis using the random-effects model again increased the level of association (OR 1.356, 95% CI 1.044–1.762; p = 0.022) [72], [82], [84], [86], [91], [97], [107], [116], [121]–[123]. Significant heterogeneity and an increased level of association as compared with the total population were also observed using the random-effects model for the ≤55 and ≤65 year-old subgroups.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

2014

View full text Add to dashboard Cite

BackgroundThe PlA2 polymorphism of glycoprotein IIIa (GPIIIa) has been previously identified as being associated with myocardial infarction (MI), but whether this represents a true association is entirely unclear due to differences in findings from different studies. We performed a meta-analysis to evaluate whether this polymorphism is a risk factor for MI.MethodsElectronic databases (MEDLINE and EMBASE) were searched for all articles evaluating genetic polymorphisms of GPIIIa. For studies where acute coronary events were recorded in association with genetic analysis, pooled odds ratios (ORs) were calculated using fixed-effects and random-effects models. The primary outcome measure was MI, and a secondary analysis was also performed for acute coronary syndromes (ACS) more generally.Findings57 studies were eligible for statistical analysis and included 17,911 cases and 24,584 controls. Carriage of the PlA2 allele was significantly associated with MI (n = 40,692; OR 1.077, 95% CI 1.024–1.132; p = 0.004) but with significant publication bias (p = 0.040). The degree of association with MI increased with decreasing age of subjects (≤45 years old: n = 9,547; OR 1.205, 95% CI 1.067–1.360; p = 0.003) and with adjustment of data for conventional cardiovascular risk factors (n = 12,001; OR 1.240, 95% CI 1.117–1.376; p<0.001). There was a low probability of publication bias for these subgroup analyses (all p<0.05).ConclusionsThe presence of significant publication bias makes it unclear whether the association between carriage of the PlA2 allele and MI is true for the total population studied. However for younger subjects, the relative absence of conventional cardiovascular risk factors results in a significant association between carriage of the PlA2 allele and MI.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

2014

View full text Add to dashboard Cite

show abstract

“…The causes of this ethnic predisposition to CAD are likely to be multi-factorial ie interaction between genetic and environmental factors. The role of inherited predisposition to coronary thrombosis is limited to certain genetic factors as shown by a recent study [23] in young north Indian survivors of AMI. More importantly, several studies [19][20][21][22] have shown that Indians are prone to developing metabolic abnormalities at a lower BMI and lower waist circumference.…”

Section: Discussionmentioning

confidence: 99%

Acute myocardial infarction: Clinical features and outcomes in young adults in Singapore

Wong

Loh²,

Loh³

et al. 2012

WJC

View full text Add to dashboard Cite

AIM:To investigate the clinical features and in-hospital outcomes of young adults with acute myocardial infarction (AMI) in Singapore. METHODS:Between January 2005 to September 2010, 333 consecutive patients aged ≤ 45 years old were diagnosed to have AMI at our institution. As Singapore is a multi-ethnic society, we also analysed whether ethnic differences exist between the three dominant ethnic groups, Malay, Chinese and Indian with regards to the clinical features. Clinical data was collected retrospectively on demographic characteristics, presenting signs and symptoms, blood investigation, angiographic findings and in-hospital clinical outcomes. RESULTS:The mean age at presentation was 40.2 ± 4.0 years with male predominance (94%). The majority of patients were Chinese (51%) followed by Indians (31%) and Malays (18%). The most common risk factor was smoking (74%) followed by hypertension (28.5%) and hyperlipidemia (20.0%). 37% of patients were obese. The majority of patients had single vessel disease (46%) on coronary angiography. The mean total cholesterol, low-density lipoprotein and highdensity lipoprotein levels were 5.6 ± 1.2 mmol/L, 3.8 ± 1.1 mmol/L and 0.93 ± 0.25 mmol/L respectively. The mean left ventricular function was 44% ± 10% with the incidence of heart failure 3% and cardiogenic shock 4.5%. Overall in-hospital mortality was low with 4 deaths (1.2%). For ethnic subgroup analysis, Indians have a 3-fold risk of developing premature AMI when compared to other ethnic groups. CONCLUSION:Young AMI patients in Singapore are characterized by male predominance, high incidence of smoking and obesity. Overall in-hospital clinical outcomes are favourable. Among the 3 ethnic groups, Indians have the highest risk of developing premature AMI.

show abstract

“…CAD is caused by a thrombotic occlusion of coronary arteries triggered by atherosclerotic plaque disruption, resulting in an activation of coagulation processes [4]. It is a complex, multifactorial, and polygenic disorder that involves an interaction between genetic predisposition and environmental factors [5]. It has been shown that traditional risk factors, including diet, obesity, diabetes, hypertension, dyslipidemia, inflammation, smoking, and alcohol consumption, allow the prediction of only about 50% of the absolute risk of a cardiovascular event in individual patients [6,7], and the remaining risk is attributed to genetic influences [8].…”

Section: Introductionmentioning

confidence: 99%

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Alizadeh¹,

Djafarian²,

Alizadeh

et al. 2017

Lifestyle Genomics

View full text Add to dashboard Cite

Background and Aims:ApaI, FokI, TaqI, and BsmI polymorphisms in the vitamin D receptor (VDR) gene have been reported to be associated with the risk of coronary artery disease (CAD), although the results of previous studies have been inconsistent. The aim of this study was to explore whether these polymorphisms play a role in the genetic susceptibility to CAD. Methods: A comprehensive search of Medline and Embase databases was conducted for studies evaluating the association between the VDR polymorphisms and CAD risk. Odds ratios with 95% confidence intervals were calculated to assess the strength of association in the dominant model, recessive model, allelic model, and genotypes contrast. Results: Nine studies involving a total of 5,259 cases and 1,981 controls were finally included in this meta-analysis. Overall, no significant associations were found between ApaI, FokI, TaqI, and BsmI polymorphisms and the risk of CAD in any of the genetic models (all p ˃ 0.05). Moreover, a subgroup analysis by ethnicity did not reveal a significant relationship between any of the examined polymorphisms and CAD risk in Caucasians and East-Asians for any model (all p ˃ 0.05). Conclusion: Current evidence suggests that the ApaI, FokI, TaqI, and BsmI polymorphisms of the VDR gene might not be associated with genetic susceptibility to CAD. Further well-designed studies with large sample sizes are needed to confirm our results.

show abstract

Prothrombotic gene polymorphisms and plasma factors in young north Indian survivors of acute myocardial infarction

Cited by 25 publications

References 27 publications

The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

Acute myocardial infarction: Clinical features and outcomes in young adults in Singapore

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About