Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Alizadeh, Shahab; Djafarian, Kurosh; Alizadeh, Hamzeh; Mohseni, Reza; Shab‐Bidar, Sakineh

doi:10.1159/000455914

Cited by 31 publications

(24 citation statements)

References 36 publications

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“…Another approach is the Mendelian randomization (MR) procedure [5], and there are several single nucleotide polymorphisms (SNPs) related to enzymes needed for activation, transport and breakdown of vitamin D, as well as in the VDR. However, the results have not consistently been in favour of vitamin D. Thus, SNPs related to synthesis and breakdown of 25 Similarly, there have been numerous studies on VDR SNPs, in particular regarding cancer, but also these have shown conflicting results [12,13].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the vitamin D system and mortality - The Tromsø study

Jorde

Wilsgaard

Grimnes

2019

Preprint

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Background and objectiveVitamin D deficiency is associated with diabetes, cancer, immunological and cardiovascular diseases as well as increased mortality. It has, however, been difficult to show a causal relation in randomized, controlled trials. Mendelian randomization studies provide another option for testing causality, and results indicate relations between the serum 25hydroxyvitamin D (25(OH)D) level and some diseases, including mortality. We have from the Tromsø Study in 2012 published non-significant relations been vitamin D related single nucleotide polymorphisms (SNPs) and mortality, but have since then genotyped additional subjects, the observation time is longer and new SNPs have been included. Methods Genotyping was performed for SNPs in the NADSYN1, CYP2R1, VDR, CUBILIN and MEGALIN genes in 11 897 subjects who participated in the fourth survey of the Tromsø Study in 1994-1995. Serum 25(OH)D levels were measured in 6733 of these subjects. A genotype score based on SNPs in the NADSYN1 and CYP2R1 genes (related to the serum 25(OH)D level) and serum 25(OH)D percentile groups were created. Mortality data was updated till end of March 2017 and survival analysed with Cox regression adjusted for sex and age. ResultsDuring the observation period 5491 subjects died. The genotype score and the serum 25(OH)D percentile groups were (without Bonferroni correction) significantly related to mortality in favour of high serum 25(OH)D. None of the SNPs in the VDR or MEGALIN genes were related to mortality. However, for the rs12766939 in the CUBILIN gene with the major homozygote as reference, the hazard ratio for mortality for the minor homozygote genotype was 1.17 (1.06 -1.29), P < 0.002. This should be viewed with caution, as rs12766939 was not in Hardy-Weinberg equilibrium. ConclusionOur study confirms a probable causal but weak relation between serum 25(OH)D level and mortality. The relation between rs12766939 and mortality needs confirmation in more homogenous cohorts.

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Section: Introductionmentioning

confidence: 99%

Polymorphisms in the vitamin D system and mortality - The Tromsø study

Jorde

Wilsgaard

Grimnes

2019

Preprint

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“…It is well‐known that VDR is variable across human populations. Several single nucleotide polymorphisms (SNPs) have been described, some of them (e.g., rs1544410, rs731236, rs2228570, and rs7975232, also known as BsmI, TaqI, FokI, and ApaI, respectively) because they are associated with several phenotypes of interest (bone mineral density, protection/susceptibility from ovarian and breast cancer, among others) (Alizadeh, Djafarian, Alizadeh, Mohseni, & Shab‐Bidar, 2017; Nunes et al, 2016; Santoro et al, 2015). Hochberg and Templeton (2010) proposed that VDR alleles belong to the evolutionary complex that adapts humans to UVR to the different exposure levels.…”

Section: Human Skin Color Variation and The Role Of The Vitamin D Undmentioning

confidence: 99%

Adaptation and co‐adaptation of skin pigmentation and vitamin D genes in native Americans

Missaggia

Reales

Cybis

et al. 2020

American J of Med Genetics Pt C

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We carried out an exhaustive review regarding human skin color variation and how much it may be related to vitamin D metabolism and other photosensitive molecules. We discuss evolutionary contexts that modulate this variability and hypotheses postulated to explain them; for example, a small amount of melanin in the skin facilitates vitamin D production, making it advantageous to have fair skin in an environment with little radiation incidence. In contrast, more melanin protects folate from degradation in an environment with a high incidence of radiation. Some Native American populations have a skin color at odds with what would be expected for the amount of radiation in the environment in which they live, a finding challenging the so‐called “vitamin D–folate hypothesis.” Since food is also a source of vitamin D, dietary habits should also be considered. Here we argue that a gene network approach provides tools to explain this phenomenon since it indicates potential alleles co‐evolving in a compensatory way. We identified alleles of the vitamin D metabolism and pigmentation pathways segregated together, but in different proportions, in agriculturalists and hunter‐gatherers. Finally, we highlight how an evolutionary approach can be useful to understand current topics of medical interest.

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“…A recent meta-analysis on 5259 cases with risk of coronary artery disease (CAD) and 1981 controls showed that Fok I, Bsm I, Taq I, and Apa I polymorphisms in the VDR might not be associated with CAD [52].…”

Section: Vdrmentioning

confidence: 99%

Vitamin D and Rehabilitation after Stroke: Status of Art

Siotto¹,

Santoro²,

Aprile³

2020

Applied Sciences

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Stroke is the first cause of disability in the population and post-stroke patients admitted to rehabilitation units often present a malnutrition status which can influence nutritional indices and then vitamin levels. Vitamin D deficiency seems implicated beyond stroke severity and stroke risk, and also affects post-stroke recovery. Some studies on vitamin D levels and outcome in stroke patients are available but very few data on vitamin D levels and outcome after rehabilitation treatment are reported. This literature review shows the possible relationship between vitamin D deficiency and recovery in post-stroke patients undergoing rehabilitation treatment. Moreover, because several studies have reported that single nucleotide polymorphisms and promoter methylation in genes are involved in vitamin D metabolism and might affect circulating vitamin D levels, these aspects are evaluated in the current paper. From the studies evaluated in this review, it emerges that vitamin D deficiency could not only have an important role in the recovery of patients undergoing rehabilitation after a stroke, but that genetic and epigenetic factors related to vitamin D levels could have a crucial role on the rehabilitation outcome of patients after stroke. Therefore, further studies are necessary on stroke patients undergoing rehabilitation treatment, including: (a) the measurement of the 25(OH) vitamin D serum concentrations at admission and post rehabilitation treatment; (b) the identification of the presence/absence of CYP2R1, CYP27B1, CYP24A1 and VDR polymorphisms, and (c) analysis of the methylation levels of these genes pre- and post-rehabilitation treatment.

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Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Cited by 31 publications

References 36 publications

Polymorphisms in the vitamin D system and mortality - The Tromsø study

Polymorphisms in the vitamin D system and mortality - The Tromsø study

Adaptation and co‐adaptation of skin pigmentation and vitamin D genes in native Americans

Vitamin D and Rehabilitation after Stroke: Status of Art

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