Proteomic analysis reveals differentially secreted proteins in the urine from patients with clear cell renal cell carcinoma

Sandim, Vanessa; Pereira, Denise de Abreu; Kalume, Dário Eluan; Oliveira-Carvalho, Ana Lúcia; Ornellas, Antônio Augusto; Soares, Márcia Regina; Alves, Gilda; Zingali, Russolina B.

doi:10.1016/j.urolonc.2015.07.016

Cited by 35 publications

(27 citation statements)

References 29 publications

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“…Other evidence suggested that elevated cellular APOD expression correlated with malignant transformation of the prostate . The content of APOD was increased in the urine of patients with renal cell cancer …”

Section: Apolipoproteins and Cancermentioning

confidence: 99%

Apolipoproteins and cancer

Ren

Wan

et al. 2019

Cancer Medicine

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The role of apolipoproteins in cardiovascular disease has been well investigated, but their participation in cancer has only been explored in a few published studies which showed a close link with certain kinds of cancer. In this review, we focused on the function of different kinds of apolipoproteins in cancers, autophagy, oxidative stress, and drug resistance. The potential application of apolipoproteins as biomarkers for cancer diagnosis and prognosis was highlighted, together with an investigation of their potential as drug targets for cancer treatment. Many important roles of apolipoproteins and their mechanisms in cancers were reviewed in detail and future perspectives of apolipoprotein research were discussed.

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Section: Apolipoproteins and Cancermentioning

confidence: 99%

Apolipoproteins and cancer

Ren

Wan

et al. 2019

Cancer Medicine

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“…Multidimensional analyses have also been applied by Sandim et al. to evaluate the differentially secreted proteins in the urine of three groups of patients (control group, CG; good prognosis group, GP; poor prognosis group, PP) with clear cell renal cell carcinoma. These strategies involved the use of: 1DE combined with LC‐MS/MS; label‐free 1D LC‐MS (1D LC‐MS) after in‐solution digestion of proteins, and 2DE combined with MALDI‐TOF/TOF or LC‐MS/MS.…”

Section: Multidimensional Chromatography and Complementarity With Othmentioning

confidence: 99%

Do the complementarities of electrokinetic and chromatographic procedures represent the “Swiss knife” in proteomic investigation? An overview of the literature in the past decade

et al. 2017

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This report reviews the literature of the past decade dealing with the combination of electrokinetic and chromatographic strategies in the proteomic field. Aim of this article is to highlight how the application of complementary techniques may contribute to substantially improve protein identification. Several studies here considered demonstrate that exploring the combination of these approaches can be a strategy to enrich the extent of proteomic information achieved from a sample. The coupling of "top-down" and "bottom-up" proteomics may result in the generation of a hybrid analytical tool, very efficient not only for large-scale profiling of complex proteomes but also for studying specific subproteomes. The range of applications described, while evidencing a continuous boost in the imagination of researchers for developing new combinations of methods for protein separation, also underlines the adaptability of these techniques to a wide variety of samples. This report points out the general usefulness of combining different procedures for proteomic analysis, an approach that allows researchers to go deeper in the proteome of samples under investigation.

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“…To identify markers predictive for poor prognosis, Sandim et al assessed the urinary proteome of ccRCC patients using three independent MS platforms. The authors identified decreased expression of KNG1, UMOD, APOD, polyubiquitin (UBB and UBC) and CD59 in patients with poor prognosis compared to those with good prognosis [52]. Standardization of technology platforms and sample preparation will have to be achieved before the clinical utility of these markers can be realized.…”

Section: Clinical Application In Cancermentioning

confidence: 99%

Proteomics and peptidomics: moving toward precision medicine in urological malignancies

2016

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Urological malignancies are a major cause of morbidity and mortality worldwide. Advances in early detection, diagnosis, prognosis and prediction of treatment response can significantly improve patient care. Proteomic and peptidomic profiling studies are at the centre of kidney, prostate and bladder cancer biomarker discovery and have shown great promise for improved clinical assessment. Mass spectrometry (MS) is the most widely employed method for proteomic and peptidomic analyses. A number of MS platforms have been developed to facilitate accurate identification of clinically relevant markers in various complex biological samples including tissue, urine and blood. Furthermore, protein profiling studies have been instrumental in the successful introduction of several diagnostic multimarker tests into the clinic. In this review, we will provide a brief overview of high-throughput technologies for protein and peptide based biomarker discovery. We will also examine the current state of kidney, prostate and bladder cancer biomarker research as well as review the journey toward successful clinical implementation.

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Proteomic analysis reveals differentially secreted proteins in the urine from patients with clear cell renal cell carcinoma

Cited by 35 publications

References 29 publications

Apolipoproteins and cancer

Apolipoproteins and cancer

Do the complementarities of electrokinetic and chromatographic procedures represent the “Swiss knife” in proteomic investigation? An overview of the literature in the past decade

Proteomics and peptidomics: moving toward precision medicine in urological malignancies

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