Apolipoproteins and cancer

Ren, Liwen; Yi, Jie; Wan, Li; Zheng, Xiangjin; Liu, Jinyi; Wang, Jinhua; Du, Guanhua

doi:10.1002/cam4.2587

Cited by 88 publications

(74 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 6 shows the resulting estimates (log-rank test P < 10 −5 ). Apolipoprotein D (APOD) is primarily down-divergent in the gene expression data, and low expression of it has been noted to be associated with poor prognosis in breast cancer [ 17 , 18 ]. Regulator of G protein signaling 6 (RGS6), which is down-divergent in most tumor samples, has been observed to be a suppressor of breast cancer [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

An R package for divergence analysis of omics data

Dinalankara

Geman

et al. 2021

PLoS ONE

View full text Add to dashboard Cite

Given the ever-increasing amount of high-dimensional and complex omics data becoming available, it is increasingly important to discover simple but effective methods of analysis. Divergence analysis transforms each entry of a high-dimensional omics profile into a digitized (binary or ternary) code based on the deviation of the entry from a given baseline population. This is a novel framework that is significantly different from existing omics data analysis methods: it allows digitization of continuous omics data at the univariate or multivariate level, facilitates sample level analysis, and is applicable on many different omics platforms. The divergence package, available on the R platform through the Bioconductor repository collection, provides easy-to-use functions for carrying out this transformation. Here we demonstrate how to use the package with data from the Cancer Genome Atlas.

show abstract

Section: Resultsmentioning

confidence: 99%

An R package for divergence analysis of omics data

Dinalankara

Geman

et al. 2021

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…They transport lipids and hydrophobic vitamins in the blood, cerebrospinal fluid and lymph (Ren et al . 2019). APOs act as ligands for cell membrane receptors and enzyme cofactors (e.g.…”

Section: Resultsmentioning

confidence: 99%

“…Apolipoproteins and related proteins Apolipoproteins (APOs) are proteins that bind lipids to form lipoprotein particles. They transport lipids and hydrophobic vitamins in the blood, cerebrospinal fluid and lymph (Ren et al 2019). APOs act as ligands for cell membrane receptors and enzyme cofactors (e.g.…”

Section: Transport and Metabolism Of Lipidsmentioning

confidence: 99%

Insights into gene expression responses to infections in teleosts using microarray data: a systematic review

Caruffo

Mandaković²,

Cabrera³

et al. 2020

Reviews in Aquaculture

View full text Add to dashboard Cite

The rapid growth of production in aquaculture in the last decades has brought unwanted consequences affecting fish health and increasing the susceptibility to different infections. This systematic review aimed to analyse and summarize the current knowledge of gene expression responses to infectious diseases in teleosts using viruses, bacteria, fungi and parasites as agents through published microarray data. We conducted searches in electronic databases, including PubMed, Web of Science and SCOPUS until 1 May 2019. We identified 862 citations across databases and manual searches. After removing duplicates, we screened 455 unique references using titles and abstracts, of which 262 proved potentially eligible and evaluated using full text. A total of 79 articles proved eligible for this review. From the articles retrieved, we examined 261 different experiments (or 'studies') and more than a hundred thousand differentially expressed genes (DEGs). This systematic review represents the first catalogue of genes (and their associated processes) that differentially transcribe in different teleost species (13 species) due to infections generated by a large variety of pathogens (38 types). Although the obtained gene expression results are in considerable measure associated with expected immune response, other genes showed surprising significant transcriptional outcomes that may unravel unknown functions related to fish infections. This type of investigations facilitates the visualization of existing gaps in researches that may inspire future analysis in non-traditional but relevant host or pathogen species.

show abstract

“…In keeping with these observations, APOLs were suspected to be involved in several cancers, including cervical, ovarian, breast, thyroid, bladder, prostate and colorectal cancers [12,112–116].…”

Section: Apols and Cancermentioning

confidence: 94%

The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection

Pays

2020

The FEBS Journal

View full text Add to dashboard Cite

The discovery that apolipoprotein L1 (APOL1) is the trypanolytic factor of human serum raised interest about the function of APOLs, especially following the unexpected finding that in addition to their protective action against sleeping sickness, APOL1 C-terminal variants also cause kidney disease. Based on the analysis of the structure and trypanolytic activity of APOL1, it was proposed that APOLs could function as ion channels of intracellular membranes and be involved in mechanisms triggering programmed cell death. In this review, the recent finding that APOL1 and APOL3 inversely control the synthesis of phosphatidylinositol-4-phosphate (PI(4)P) by the Golgi PI(4)-kinase IIIB (PI4KB) is commented. APOL3 promotes Ca 2+-dependent activation of PI4KB, but due to their increased interaction with APOL3, APOL1 C-terminal variants can inactivate APOL3, leading to reduction of Golgi PI(4)P synthesis. The impact of APOLs on several pathological processes that depend on Golgi PI(4)P levels is discussed. I propose that through their effect on PI4KB activity, APOLs control not only actomyosin activities related to vesicular trafficking, but also the generation and elongation of autophagosomes induced by inflammation.

show abstract

Apolipoproteins and cancer

Cited by 88 publications

References 147 publications

An R package for divergence analysis of omics data

An R package for divergence analysis of omics data

Insights into gene expression responses to infections in teleosts using microarray data: a systematic review

The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection

Contact Info

Product

Resources

About