Proteinuria in preeclampsia: Not essential to diagnosis but related to disease severity and fetal outcomes

Dong, Xin; Gou, Wei; Li, Chunfang; Wu, Min; Han, Zhen; Li, Xuelan; Chen, Qi

doi:10.1016/j.preghy.2017.03.005

Cited by 67 publications

(69 citation statements)

References 21 publications

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“…In addition, 75 percent of patients who showed no severe preeclampsia features had proteinuria levels of less than 3 g/day. This data is similar to that in the literature [11].…”

Section: Discussionsupporting

confidence: 93%

“…This study showed significantly high rates of retinal detachment and pleural effusion in patients with massive proteinuria, while in our study, we observed none of these complications. The same study also showed similar eclampsia rates between patients with massive vs. mild proteinuria [11]. Mateus et al found no significant relationship between eclampsia and the amount of proteinuria in a recent study they did in 2017 [12].…”

Section: Discussionmentioning

confidence: 66%

“…The preeclampsia without proteinuria rate is about 10 percent [9]. Many studies showed that high levels of proteinuria were highly related to fetal and maternal morbidity [10][11][12][13]. In our clinic, we did not have any preeclampsia patients without proteinuria on the given dates, so no group was formed as "patients with no proteinuria or patients with proteinuria less than 300 mg. " The reason for that might be the accustomed strong coexistence of preeclampsia with proteinuria in most of the clinicians' minds.…”

Section: Discussionmentioning

confidence: 94%

“…There is no solid evidence about the threshold of proteinuria which classifies it as severe. Some studies identify the 24-hour urine protein level threshold for severe proteinuria as being at least 3 g or more, and some identify it as 5 g or more in the literature [11,20,21]. Because only 6 percent of our patient population had a proteinuria level of at least 5 g or more, in order to have an appropriate statistical analysis between groups, we identified the severe proteinuria threshold as 3 g.…”

Section: Discussionmentioning

confidence: 99%

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Proteinuria in preeclampsia: is it important?

et al. 2018

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“…In addition, 75 percent of patients who showed no severe preeclampsia features had proteinuria levels of less than 3 g/day. This data is similar to that in the literature [11].…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Proteinuria in preeclampsia: is it important?

et al. 2018

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“…Hypertension and proteinuria are very common outside the postpartum period in Cameroonian women with severe PE and eclampsia [28]. In severe PE with proteinuria >3 g/L showed that the amount of proteinuria is not associated with severe PE, although proteinuria is detected, prematurity may occur [29]. Serum cytoglobin was significantly more effective and higher in patients with early-onset preeclampsia (EO-PE) and slow onset of preeclampsia (LOPE), compared with healthy pregnant women [30].…”

Section: Biomarker In Pementioning

confidence: 99%

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

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Preeclampsia (PE) have a high risk of pregnancy disorder and can cause liver and kidney disease. PE is a dangerous disease in Indonesia with a high risk of cardiovascular death. PE has biomarkers such as proteinuria, blood pressure, dipstick test, renin-angiotensin system, adipsin, calcium/ creatinine (Cr) ratio, albumin/Cr ratio, and uric acid. Apoptosis occurs in the placenta’s PE, where trophoblasts invade and overhaul the uterine spiral artery in the epidermal growth factor signaling system, and the expression of miRNA in PE is targeting genes in a variety of pathophysiological processes can cause kidney and hepatic disease. In this review, we will discuss role of HSP, miRNA, Immunology cell and the risk of kidney and hepatic disease of patient of Preeclampsia.

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Proteinuria in predicting adverse outcomes in women with severe features of pre‐eclampsia from a developing country: A prospective cohort study

Murali,

Rengaraj,

Priyamvada

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo study the adverse maternal and perinatal outcomes in women with severe pre‐eclampsia (SPE) among different ranges of proteinuria.MethodsThis prospective cohort study was conducted in Jawaharlal Institute of Postgraduate Medical Education and Research, India. After obtaining informed written consent, the 202 singleton women fulfilling the criteria of severe features of pre‐eclampsia were stratified based on the value of urine protein‐creatinine ratio (UPCR) as mild, moderate, severe, and massive proteinuria during pregnancy. Clinical outcomes were assessed and patients were followed up until 12 weeks postpartum to identify persistent proteinuria and hypertension.ResultsOf the 202 women with SPE, adverse maternal outcomes were seen in 34.65% (n = 70) and adverse perinatal outcomes in 75.74% (n = 153). The demographic and clinical factors were similar among women with increasing severity of proteinuria, except for mean systolic blood pressure, serum creatinine and total serum protein. UPCR was found to have a significant correlation with composite adverse perinatal outcome (P < 0.001) and individual outcomes of neonatal intensive care unit admission for >48 h (P = 0.01) and neonatal sepsis (P = 0.02) but not adverse maternal outcomes (P = 0.201). The optimum UPCR cutoff for adverse perinatal outcomes was 1.6 (sensitivity, 73.2%; specificity, 52.7%). In addition, 14.85% of the women had a persistently elevated UPCR and 3.96% had hypertension at 3 months postpartum.ConclusionIn women with SPE, severe and massive proteinuria were related to composite adverse perinatal outcome but not composite adverse maternal outcome. Moreover, antenatal 24‐h proteinuria was significantly associated with persistent proteinuria. Significant proteinuria in women with SPE poses a risk for chronic renal dysfunction, requiring follow‐up.

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Proteinuria in preeclampsia: Not essential to diagnosis but related to disease severity and fetal outcomes

Cited by 67 publications

References 21 publications

Proteinuria in preeclampsia: is it important?

Proteinuria in preeclampsia: is it important?

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Proteinuria in predicting adverse outcomes in women with severe features of pre‐eclampsia from a developing country: A prospective cohort study

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