“…When compared with Pb265, virulent strain Pb18 co-cultured with neutrophils has a higher expression of PADG_08528, which is a hypothetical protein in the fungus genome (Desjardins et al, 2011), suggesting that this gene may be related to the production of DNAse-like protein (Zonta et al, 2020). In addition to degrading chromatins, degrading NETs proteins by Saps secreted by C.albicans is another available method (Rapala-Kozik et al, 2015;Gogol et al, 2016;Karkowska-Kuleta et al, 2021). LL-37 and histones are most sensitive components to Saps, especially Saps3 and Saps9, which are most effective in NETs proteins degradation and weakening NETs (Rapala-Kozik et al, 2015;Karkowska-Kuleta et al, 2021).…”