Protein detecting with smartphone-controlled electrochemical impedance spectroscopy for point-of-care applications

Zhang, Diming; Lu, Yanli; Zhang, Qian; Liu, Lei; Li, Shuang; Yao, Yao; Jiang, Jing; Liu, Gang Logan; Liu, Qingjun

doi:10.1016/j.snb.2015.09.041

Cited by 117 publications

(65 citation statements)

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“…Bluetooth, used in [9,32], is another communication method that can be found in most new mobile devices. The major benefits of Bluetooth are the higher data rate (270 kbps using Bluetooth Low Energy compared to <2 kbps in this work) and the ability to physically separate the electronic module from the phone, which is especially advantageous for wearable applications [32].…”

Section: Resultsmentioning

confidence: 99%

“…Finally, while all the other electrochemical biosensors using the headphone jack have batteries, our device is able to harvest its power directly from the smartphone. While these batteries offer enough power to perform more types of tests [13] as well as implement more intensive techniques [9], we have shown that harvesting power from the headphone port is enough to implement a CV based biosensor with comparable sensitivity. Furthermore, power harvesting eliminates the hassle of having to either replace or charge a battery in addition to the phone’s battery improving user convenience for periodic use.…”

Section: Resultsmentioning

confidence: 99%

“…Developing peripheral molecular sensors, which detect and monitor a variety of disease biomarkers, for mobile phones would enable numerous POC applications allowing doctors to conduct diagnostic tests in remote settings and individuals to run simple medical tests without visiting a lab, improving the convenience, speed, and quality of medical diagnoses. While devices exist that use a part of the mobile phone for molecular tests, such as the camera [3–8], Bluetooth [9], proprietary ports [10–12], or the audio port [13,14], our intention was to develop a platform that integrates seamlessly with the smartphone by using sensitive electrochemical detection to forgo bulky external equipment typical of optical sensing methods and reducing redundant electronics in the peripheral that already exists on the phone. By focusing on making the peripheral more closely integrated with the mobile device and easier both to manage and carry around, a platform can be developed that can be more readily adopted by individuals and can encourage and promote adherence to frequent POC monitoring and testing.…”

Section: Introductionmentioning

confidence: 99%

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An efficient power harvesting mobile phone-based electrochemical biosensor for point-of-care health monitoring

Sun

Yao

Venkatesh

et al. 2016

Sensors and Actuators B: Chemical

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Cellular phone penetration has grown continually over the past two decades with the number of connected devices rapidly approaching the total world population. Leveraging the worldwide ubiquity and connectivity of these devices, we developed a mobile phone-based electrochemical biosensor platform for point-of-care (POC) diagnostics and wellness tracking. The platform consists of an inexpensive electronic module (< $20) containing a low-power potentiostat that interfaces with and efficiently harvests power from a wide variety of phones through the audio jack. Active impedance matching improves the harvesting efficiency to 79%. Excluding loses from supply rectification and regulation, the module consumes 6.9 mW peak power and can measure < 1 nA bidirectional current. The prototype was shown to operate within the available power budget set by mobile devices and produce data that matches well with that of an expensive laboratory grade instrument. We demonstrate that the platform can be used to track the concentration of secretory leukocyte protease inhibitor (SLPI), a biomarker for monitoring lung infections in cystic fibrosis patients, in its physiological range via an electrochemical sandwich assay on disposable screen-printed electrodes with a 1 nM limit of detection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An efficient power harvesting mobile phone-based electrochemical biosensor for point-of-care health monitoring

Sun

Yao

Venkatesh

et al. 2016

Sensors and Actuators B: Chemical

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“…In this sense, only few attempts of potentiostat miniaturization can be found in the literature [6][7][8][9], and some important concerns always arise. Some authors focused on adapting already existing portable electronics to perform cyclic voltammetry.…”

Section: Introductionmentioning

confidence: 99%

“…This is the case of Cruz et al [6], who integrated a LMP91000EVM commercial chip and a BeagleBone (Texas Instruments, Dallas, TX, USA) development board. As for portable impedance measurements, an interesting work is presented by Zhang et al [7], who, according to the same philosophy, integrated a commercial miniaturized impedance analyzer AD5933 (Analog Devices, Norwood, MA, USA) with an Arduino UNO board and a Bluetooth module for BSA immunosensing applications. Similarly, Li et al [8] developed a detector combined with a 3D-printed USB-compatible chip to sense aflatoxins in rice.…”

Section: Introductionmentioning

confidence: 99%

Low-Cost Impedance Measurements for Lab-on-a-Chip Architectures: Towards Potentiostat Miniaturization

Pruna

Palacio

Baraket

et al. 2017

Proceedings of Eurosensors 2017, Paris, France, 3–6 September 2017

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Abstract:The development of miniaturized potentiostats capable of measuring in a wide range of conditions and with full characteristics (e.g., wide bandwidth and capacitive/inductive contribution to sensor's impedance) is still an unresolved challenge in bioelectronics. We present a simple analogue design coupled to a digital filter based on a lock-in amplifier as an alternative to complex architectures reported hitherto. A low-cost, miniaturized and fully integrated acquisition electronic system was developed, tested for a fully integrated three-lead electrochemical biosensor and benchmarked against a commercial potentiostat. The portable potentiostat was coupled to an array of miniaturized gold working electrodes to perform complex impedance analyses for tumor necrosis factor α (TNF-α) cytokine detection. This wearable potentiostat is very promising for the development of low-cost point-of-care (POC) with low power consumption.

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Chemical and Biochemical Sensors, 2. Applications

Bârsan

Gauglitz

Oprea

et al. 2016

Ullmann's Encyclopedia of Industrial Chemistry

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The article contains sections titled: 1. Introduction 2. Chemical Sensors 2.1. Gas Sensors 2.1.1. Humidity Sensors 2.1.1.1. General Considerations 2.1.1.2. Humidity Sensors Types 2.1.1.3. Humidity Sensors in Applications 2.1.2. Semiconducting Metal Oxides 2.1.2.1. History and Current Status 2.1.2.2. Operation Principle and Materials 2.1.2.3. Fabrication Technology 2.1.2.4. Electronic Circuitries for Signal Generation 2.1.2.5. Sensor Properties and Specifications 2.1.2.6. Fields of Application 2.1.2.7. Future Trends 2.2. Electronic Noses and Tongues 2.2.1. Applications 2.2.2. Issues of Concern 2.2.3. Outlook 3. Biochemical Sensors 3.1. Assays 3.1.1. Assay Types and Flow Injection Analysis (FIA) 3.1.2. Marker–Label Free 4. Gas Sensors 4.1. Fields of Application 4.1.1. Indoor Air Quality Control 4.1.2. Indoor Gas Sensors for Toxic and Explosive Gases 4.1.3. Breath Gas Analysis 4.1.4. Automotive 4.2. Process Control 4.2.1. Industrial Process Sensors 4.2.1.1. Process Analytical Technology 4.2.1.2. Sensor Market 4.2.1.3. Sensors for Plant Safety 4.2.1.4. Requirements for Industrial Process Sensors 4.2.2. Sensor Integration in Process Environment 4.2.2.1. Sampling Systems 4.2.2.2. Sensor Communication 4.2.2.3. Feedback and Feedforward Control Loops 4.2.3. Application: Process Control in the Production of Renewable Energy 4.2.3.1. Biogas 4.2.3.2. Process Analytics during Fermentation and Purification 4.2.3.3. Process Analytics of Downstream Processes 4.2.3.4. Monitoring Quality Parameters and Perspectives 4.3. Point of Care Diagnostics 4.3.1. Introduction to Special Requirements 4.3.2. Areas of Application 4.3.2.1. Ambulance and Home Care 4.3.2.2. Personalized Medicine 4.3.2.3. Infections 4.3.2.4. POCT and Telemedicine 4.3.3. Devices 4.3.3.1. Lateral Flow 4.3.3.2. Benchtop 4.3.3.3. Lab‐on‐Chip Platforms 4.3.4. Trends and Perspectives 4.4. Environmental and Food Analytics 4.4.1. Introduction 4.4.1.1. Water Analysis 4.4.1.2. Food 4.4.2. Trends and Perspectives 4.5. Sensors with Multiplexing Approaches: Microplates and Microarrays 4.6. Further Applications 4.6.1. Special Fluorescence Sensor Applications 4.6.1.1. Blood Monitoring 4.6.1.2. Pressure Sensitive Paints 4.6.2. Mass Sensitive Sensors 4.6.2.1. Gas Phase 4.6.2.2. Liquid Phase 4.6.2.3. Biosensors

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Protein detecting with smartphone-controlled electrochemical impedance spectroscopy for point-of-care applications

Cited by 117 publications

References 50 publications

An efficient power harvesting mobile phone-based electrochemical biosensor for point-of-care health monitoring

An efficient power harvesting mobile phone-based electrochemical biosensor for point-of-care health monitoring

Low-Cost Impedance Measurements for Lab-on-a-Chip Architectures: Towards Potentiostat Miniaturization

Chemical and Biochemical Sensors, 2. Applications

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