2015
DOI: 10.4049/jimmunol.1401032
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Protective Role of STAT6 in Basophil-Dependent Prurigo-like Allergic Skin Inflammation

Abstract: Prurigo is a common, but treatment-resistant, skin disease characterized by persistent papules/nodules and severe itching. Prurigo occurs in association with various underlying diseases, such as diabetes, chronic renal failure, and internal malignancies. Atopic dermatitis is occasionally complicated by prurigo lesions. However, the pathology of prurigo is completely undefined. We demonstrate that repeated intradermal administration of Ag to IgE-transgenic mice causes persistent and pruritic papulonodular skin … Show more

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Cited by 33 publications
(40 citation statements)
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“…p-STAT6 is closely related to epithelial cell hyperplasia, which is the cause of ulcerative colitis, lung inflammation and skin inflammation. [11][12][13] To investigate whether p-STAT6 plays a similar role in GD, we first explored p-STAT6 expression in TECs from GD patients and control individuals.…”
Section: Resultsmentioning
confidence: 99%
“…p-STAT6 is closely related to epithelial cell hyperplasia, which is the cause of ulcerative colitis, lung inflammation and skin inflammation. [11][12][13] To investigate whether p-STAT6 plays a similar role in GD, we first explored p-STAT6 expression in TECs from GD patients and control individuals.…”
Section: Resultsmentioning
confidence: 99%
“…In line with its ability to down-regulate FcεRI, these patients respond to treatment with omalizumab therapy [70,79]. Further, we would predict in this setting that IL-3-elicited basophils are the primary pathogenic basophil subset since basophils are known to be critical for the pathogenesis of IgE-mediated dermatitis in mice [19,8082]. Whether omalizumab can improve outcomes in other IgE- and basophil-associated diseases such as food allergy is currently under investigation [83].…”
Section: Classical Regulators Of Basophil Function: Il-3 and Igementioning
confidence: 99%
“…2) [81,82,144]. Macrophages undergo alternative activation in the presence of IL-4 or IL-13 which is characterized by increased expression of signature genes including Arginase-I, chitinase-like molecules and resistin-like molecule α (Relmα).…”
Section: Impacts Of Basophil Heterogeneity On Other Immune Cellsmentioning
confidence: 99%
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