2016
DOI: 10.1007/s00281-016-0567-z
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New insights into basophil heterogeneity

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Cited by 27 publications
(23 citation statements)
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References 158 publications
(232 reference statements)
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“…Other studies have proposed that TSLP‐elicited basophils play a central role in the induction of Th2 responses, whereas IL‐3‐elicited basophils act as late‐phase effector cells by exhibiting IgE‐mediated degranulation and histamine release . Topical corticosteroid suppressed the upregulation of mRNA expression of IL‐4 and IL‐3 but not that of TSLP in the MC903‐treated skin of epicutaneously sensitized mice.…”
Section: Discussionmentioning
confidence: 89%
“…Other studies have proposed that TSLP‐elicited basophils play a central role in the induction of Th2 responses, whereas IL‐3‐elicited basophils act as late‐phase effector cells by exhibiting IgE‐mediated degranulation and histamine release . Topical corticosteroid suppressed the upregulation of mRNA expression of IL‐4 and IL‐3 but not that of TSLP in the MC903‐treated skin of epicutaneously sensitized mice.…”
Section: Discussionmentioning
confidence: 89%
“…Recently, the epithelial cell-derived cytokines TSLP and IL-33 have been shown to be master initiators of type 2 inflammation via their effects on a variety of cells including Th2 cells, ILC2s, and basophils (Hammad and Lambrecht, 2015; Oetjen et al, 2016). These cytokines are believed rapidly signal barrier breach in order to generate innate immune responses and help prime adaptive immune cells.…”
Section: Discussionmentioning
confidence: 99%
“…IL‐3‐elicited basophils exhibit elevated expressions of CD11b and CD62L, and higher β‐hexosaminidase release in response to IgE cross‐linking . Transcriptomic analysis revealed divergent gene expression profiles between TSLP‐ and IL‐3‐elicited murine basophils . TSLP‐elicited basophils play a role in the development of Th2‐mediated inflammation associated with helminth infections and an atopic dermatitis model …”
Section: Activating Receptors On Human Mast Cells and Basophilsmentioning
confidence: 99%
“…5 Transcriptomic analysis revealed divergent gene expression profiles between TSLP-and IL-3-elicited murine basophils. 76 TSLP-elicited basophils play a role in the development of Th2-mediated inflammation associated with helminth infections and an atopic dermatitis model. 5,6,77 It has been reported that more than 70% of activated (overnight incubation with IL-3) human basophils expressed TSLPR, and basophils isolated from the peripheral blood of patients with eosinophilic esophagitis exhibited higher levels of IL-33R.…”
Section: Tslp and Its Receptormentioning
confidence: 99%