New insights into basophil heterogeneity

Oetjen, Landon K.; Noti, Mario; Kim, Brian

doi:10.1007/s00281-016-0567-z

Cited by 28 publications

(23 citation statements)

References 158 publications

(232 reference statements)

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“…Other studies have proposed that TSLP‐elicited basophils play a central role in the induction of Th2 responses, whereas IL‐3‐elicited basophils act as late‐phase effector cells by exhibiting IgE‐mediated degranulation and histamine release . Topical corticosteroid suppressed the upregulation of mRNA expression of IL‐4 and IL‐3 but not that of TSLP in the MC903‐treated skin of epicutaneously sensitized mice.…”

Section: Discussionmentioning

confidence: 89%

Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice

Kawasaki

Ito

Murai

et al. 2018

Allergy

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Section: Discussionmentioning

confidence: 89%

Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice

Kawasaki

Ito

Murai

et al. 2018

Allergy

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“…Recently, the epithelial cell-derived cytokines TSLP and IL-33 have been shown to be master initiators of type 2 inflammation via their effects on a variety of cells including Th2 cells, ILC2s, and basophils (Hammad and Lambrecht, 2015; Oetjen et al, 2016). These cytokines are believed rapidly signal barrier breach in order to generate innate immune responses and help prime adaptive immune cells.…”

Section: Discussionmentioning

confidence: 99%

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Oetjen

Mack

Feng

et al. 2017

Cell

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722

786

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SUMMARY Mammals have evolved neurophysiologic reflexes such as coughing and scratching to expel invading pathogens and noxious environmental stimuli. It is well established that these responses are also associated with chronic inflammatory diseases such as asthma and atopic dermatitis. However, the mechanisms by which inflammatory pathways promote sensations such as itch remain poorly understood. Here, we show that type 2 cytokines directly activate sensory neurons in both mice and humans. Further, we demonstrate that chronic itch is dependent on neuronal IL-4Rα and JAK1 signaling. We also observe that patients with recalcitrant chronic itch that failed other immunosuppressive therapies markedly improve when treated with JAK inhibitors. Thus, signaling mechanisms previously ascribed to the immune system may represent novel therapeutic targets within the nervous system. Collectively, this study reveals an evolutionarily conserved paradigm in which the sensory nervous system employs classical immune signaling pathways to influence mammalian behavior.

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“…IL‐3‐elicited basophils exhibit elevated expressions of CD11b and CD62L, and higher β‐hexosaminidase release in response to IgE cross‐linking . Transcriptomic analysis revealed divergent gene expression profiles between TSLP‐ and IL‐3‐elicited murine basophils . TSLP‐elicited basophils play a role in the development of Th2‐mediated inflammation associated with helminth infections and an atopic dermatitis model …”

Section: Activating Receptors On Human Mast Cells and Basophilsmentioning

confidence: 99%

“…5 Transcriptomic analysis revealed divergent gene expression profiles between TSLP-and IL-3-elicited murine basophils. 76 TSLP-elicited basophils play a role in the development of Th2-mediated inflammation associated with helminth infections and an atopic dermatitis model. 5,6,77 It has been reported that more than 70% of activated (overnight incubation with IL-3) human basophils expressed TSLPR, and basophils isolated from the peripheral blood of patients with eosinophilic esophagitis exhibited higher levels of IL-33R.…”

Section: Tslp and Its Receptormentioning

confidence: 99%

Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

121

131

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Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory responses. However, a closer understanding of their precise roles in allergies and other pathological conditions has been marred by the considerable heterogeneity that these cells display, not only between mast cells and basophils themselves but also across different tissue locations and species. While both cell types share the ability to rapidly degranulate and release histamine following high-affinity IgE receptor cross-linking, they differ markedly in their ability to either react to other stimuli, generate inflammatory eicosanoids or release immunomodulating cytokines and chemokines. Furthermore, these cells display considerable pharmacological heterogeneity which has stifled attempts to develop more effective anti-allergic therapies. Mast cell- and basophil-specific transcriptional profiling, at rest and after activation by innate and adaptive stimuli, may help to unravel the degree to which these cells differ and facilitate a clearer understanding of their biological functions and how these could be targeted by new therapies.

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New insights into basophil heterogeneity

Cited by 28 publications

References 158 publications

Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice

Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Human mast cells and basophils—How are they similar how are they different?

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