2019
DOI: 10.1002/cia2.12061
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Efficacy of anti‐immunoglobulin E therapy in patients with prurigo: A pilot study

Abstract: Objectives Chronic prurigo is a reactive skin disease marked by multiple pruriginous lesions such as papules, nodules, and erythema. We previously showed that basophil infiltration into the pruriginous lesions and basophil activation in blood are frequently observed. Therefore, basophils may be involved in the pathogenesis of chronic prurigo. In this study, we examined the efficacy of anti‐immunoglobulin E (IgE) therapy with omalizumab, which blocks basophil activation, in patients with prurigo. Methods Seven … Show more

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Cited by 1 publication
(5 citation statements)
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References 17 publications
(42 reference statements)
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“…Analysis of treatment outcomes revealed that the efficacy of traditional therapy, such as topical steroids and UV radiotherapy, was not different in individuals with PN and PCM. In contrast, a previous clinical trial involving the treatment of chronic prurigo with omalizumab, which blocks basophil and mast cell function, reported that this compound successfully treated some patients with PCM and ameliorated eosinophilia (our preliminary data). Omalizumab was not, however, successful for other types of prurigo.…”
Section: Discussioncontrasting
confidence: 72%
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“…Analysis of treatment outcomes revealed that the efficacy of traditional therapy, such as topical steroids and UV radiotherapy, was not different in individuals with PN and PCM. In contrast, a previous clinical trial involving the treatment of chronic prurigo with omalizumab, which blocks basophil and mast cell function, reported that this compound successfully treated some patients with PCM and ameliorated eosinophilia (our preliminary data). Omalizumab was not, however, successful for other types of prurigo.…”
Section: Discussioncontrasting
confidence: 72%
“…basophil and mast cell function, reported that this compound successfully treated some patients 7,8 with PCM and ameliorated eosinophilia (our preliminary data). Omalizumab was not, however, successful for other types of prurigo.…”
Section: Discussionmentioning
confidence: 54%
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