Protective Properties of Colloidal Bismuth Subcitrate on Gastric Mucosa

Comparison of qid and bd administration of De‐Nol in the short term treatment of duodenal ulcer

“…CBS's action giving ‘physical protection’ to the ulcer lesion, as well as its ability to induce the synthesis of endogenous gastric prostaglandins, is of short duration 12 , 13 ; this would support, if anything, a more frequent daily administration of the drug. In agreement with Hollanders 4 , we believe that it is possible to suggest a positive role for CBS in affecting the qualitative composition of mucus, in increasing gastric bicarbonates (as a barrier) and in the regeneration of duodenal mucosal microvilli, the latter probably favoured by the accumulation of the drug within the lysosomes of the duodenal enterocytes 14 .…”

Effects of famotidine on gastric mucus of the rat

“…In order to stimulate synthesis of prostaglandin E2 (PGE2) the specimens were vortexed for 60 s and a 0.5 ml buffer containing 200 gM indomethacin was added to stop further prostaglandin synthesis [5]. PGE2 was determined in the supernatant using a sensitive radioimmunoassay (RIA) (Clinical Assays, Cambridge, Massa.).…”

Bismuth subcitrate in eradication regimens

“…Он выступает своеобразным стабилизатором клеточных мембран эпителиоцитов, что позволяет быстро восстановить нормальную архитектуру эпителия. Кроме защитных свойств, трикалия дицитрат висмута, попадая на поверхность слизистой оболочки эпителия, стимулирует локальный синтез простагландинов, в частности простагландина Е2 [5,11,14]. Через эту пленку уже не могут воздействовать агрессивные среды желудка -соляная кислота, ферменты.…”