Effects of famotidine on gastric mucus of the rat

Abstract

The influence of famotidine on the production of gastric mucus was studied at experimental level. We measured the quantity of the intracellular mucus, the surface adherent mucus gel thickness, and the biosynthesis of prostaglandin E2 (PGE2) by the rat gastric mucosa, in pretreated animals. Both the intracellular mucus accumulation and the adherent mucus gel thickness revealed a highly statistically significant increase (P < 0.0002). PGE2 assay showed that famotidine also led to a statistically significant increase (P = 0.02) of PGE2 in treated versus control animals. These findings raise the question of whether despite its common antisecretory pathway of action this H2-receptor antogonist could play a role in the protection of gastric mucosa. Further research is necessary to determine this.

Physical training in patients on hemodialysis has a beneficial effect on the levels of eicosanoid hormone-like substances

“…Additionally, PGE2 increases the Glomerular Filtration Rate (GFR), inhibits the reabsorption of chloride ions (Cl -) and results in increased renin secretion and erythropoeitin release. 1,2,[6][7][8][9][10][11][12][13][14] Prostacyclin Ι2 (PGI2) is another local hormone which belongs to the family of eicosanoid hormonelike substances. PGI2 has a powerful vasodilative action, inhibits the accumulation of platelets and obstructs the vasocostrictive action of thromboxane Α2.…”