Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion-induced ischaemia/reperfusion injury in rats

Tuglu, Devrim; Yuvanç, Ercan; Ozan, Tunç; Bal, Fatih; Yı́lmaz, Erdal; Atasoy, Pınar; Kısa, Üçler; Batı̇slam, Ertan

doi:10.1111/and.12499

Cited by 15 publications

(12 citation statements)

References 33 publications

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“…It also shows beneficial effects on improving histopathological parameters caused by torsion. Other phosphodiesterase inhibitors, like trapidil and dipyridamole, decreased histological damage caused by testicular torsion (16)(17)(18). Since vitamin C is a potent antioxidant, it reduces the damage caused by testicular torsion.…”

Section: Discussionmentioning

confidence: 99%

The protective effects of vasopressin on experimental testicular torsion-detorsion in male rats

Hasanvand¹,

Ahmadizar²,

Ebrahimi-Ghalaei³

et al. 2018

J Nephropharmacol

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Testicular torsion is an urgent condition in pediatric urology. Testicular torsion refers to testicular rotation around its vascular axis (spermatic cord), which results in obstruction and stoppage of blood flow and eventually the loss of living tissue (infarction). Ischemic condition causes damage to the testes due to the blood flow disruption. Furthermore, reperfusion of blood flow after ischemia (detorsion) can exacerbate the damage to the testis. Vasopressin as an antidiuretic hormone (ADH), is a pituitary hormone found in most mammals including humans. It is mainly made in supra-optic nuclei. Vasopressin is a polypeptide hormone with nine amino acids and is similar to the oxytocin hormone. In an experimental study, we found that vasopressin possesses intracellular mechanisms similar to the protective preconditioning mechanism which can reduce damages caused by ischemia-reperfusion.

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Section: Discussionmentioning

confidence: 99%

The protective effects of vasopressin on experimental testicular torsion-detorsion in male rats

Hasanvand¹,

Ahmadizar²,

Ebrahimi-Ghalaei³

et al. 2018

J Nephropharmacol

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“…The protective effect of udenafil citrate, piracetam and dexmedetomidine in different doses was evaluated by Tuglu et al[90] and found that all these agents have antioxidant effects on I/R injury.…”

Section: Searchmentioning

confidence: 99%

Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?

Vaos

Zavras

2017

WJM

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Testicular torsion (TT) is a medical emergency that primary affects newborns and young adolescents. It causes testicular injury due to the torsion of the spermatic cord and its components, initially in the venous blood flow and finally in the arterial blood flow. Prompt diagnosis and early surgical management are necessary in managing this urgent situation. The process of the pathophysiological events in ischemia-reperfusion is multifactorial and deals with the perception of the oxidative stress responsible for the consequences of ischemia/reperfusion (I/R) stress following TT. Duration and severity of torsion also play a significant role in the oxidative stress. A detrimental result of the defense system of the testes takes place resulting finally in testicular atrophy and impaired function. Antioxidant factors have been experimentally studied in an effort to front this state. They have been classified as endogenous or exogenous antioxidants. Endogenous antioxidants comprise a structure of enzymic enzymatic and non-enzymic enzymatic particles presented within cytoplasm and numerous other subunits in the cells. Exogenous antioxidants include a variety of natural and pharmaceutical agents that may prevent or ameliorate the harmful effects of I/R injury. In this study we review those factors and their ability to enhance the oxidative status of the testis. A feature insight into where we are heading is attempted.

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“…Testicular torsion is the most common cause of urological emergency in young and adolescent males (Tuglu et al, 2016 ). Once diagnosed, clinical treatment should be adopted to restore blood flow to the testis within an appropriate time frame (Kim et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

MiR-29a Suppresses Spermatogenic Cell Apoptosis in Testicular Ischemia-Reperfusion Injury by Targeting TRPV4 Channels

Ning

et al. 2017

Front. Physiol.

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Background: MicroRNAs (miRNAs) have emerged as gene expression regulators in the progression of ischemia-reperfusion injury (IRI). Accumulating evidences have indicated miR-29a play roles in myocardial and cerebral IRI. However, the role of miR-29a in testicular IRI has not been elucidated.Methods: Changes in expression of miR-29a and Transient Receptor Potential Vanilloid 4 (TRPV4) in animal samples and GC-1 spermatogenic cells were examined. The effects of miR-29a on spermatogenic cell apoptosis in testicular IRI were analyzed both in vitro and in vivo.Results: The expression of MiR-29a was negatively correlated with the expression of TRPV4 and significantly downregulated in animal samples and GC-1 cells as testicular IRI progressed. Further studies revealed TRPV4 as a downstream target of miR-29a. Inhibition of miR-29a expression increased the expression of TRPV4 and promoted spermatogenic cell apoptosis, whereas overexpression of miR-29a downregulated TRPV4 expression and suppressed spermatogenic cell apoptosis caused by testicular IRI in vitro and in vivo.Conclusion: Our results suggest that miR-29a suppresses apoptosis induced by testicular IRI by directly targeting TRPV4.

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Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion-induced ischaemia/reperfusion injury in rats

Cited by 15 publications

References 33 publications

The protective effects of vasopressin on experimental testicular torsion-detorsion in male rats

The protective effects of vasopressin on experimental testicular torsion-detorsion in male rats

Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?

MiR-29a Suppresses Spermatogenic Cell Apoptosis in Testicular Ischemia-Reperfusion Injury by Targeting TRPV4 Channels

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