Protective effects of the phytogenic feed additive “comfort” on growth performance via modulation of hypothalamic feeding- and drinking-related neuropeptides in cyclic heat-stressed broilers

Greene, Elizabeth S.; Cauble, Reagan N; Kadhim, Hakeem J.; Mallmann, Barbara; Gu, Inah; Lee, S.-O.; Orlowski, Sara; Dridi, Sami

doi:10.1016/j.domaniend.2020.106487

Cited by 18 publications

(26 citation statements)

References 72 publications

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“…This PFA consists of encapsulated essential oils, dried herbs and spices, saponins, and bulking and anticaking agents (personal communication with Delacon, Austria). Phenolic content and total antioxidant activity of the 3 diets have been previously reported ( Greene et al., 2020 ). At 8 am on day 21, the temperature was increased to 35°C in 6 of the chambers to induce HS for 12 h, after which it was reduced to 24°C each night.…”

Section: Methodsmentioning

confidence: 86%

“…Diet composition, feed intake, water consumption, body weights, and body temperature from this bird trial have been previously reported ( Greene et al., 2020 ). All animal care and procedures were approved by the Institutional Animal Care and Use Committee at the University of Arkansas.…”

Section: Methodsmentioning

confidence: 89%

“…In addition, as elevated global temperature has become a pressing concern, the impact of HS on the inflammatory response in poultry may be a significant contributor to the reductions seen in growth and productivity ( Lara and Rostagno, 2013 ), and understanding this response is necessary to better design targeted treatments or interventions. As a previous study showed that supplementation with a PFA, “Comfort”, partially ameliorated heat stress productivity loss (BW, body core temperature, and so on) ( Greene et al., 2020 ), we sought to further define here its mode of action by determining the expression profile of circulating cytokines, chemokines, and inflammasome genes in whole blood of cyclic heat-stressed broilers.…”

Section: Results and Dicussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Previously, we reported that the newly developed PFA “Comfort” (PFA-C; Delacon, Steyregg, Austria) had a high total phenolic content and antioxidant activity ( Greene et al., 2020 ). Dietary supplementation with PFA-C decreased body core temperature, increased feed and water intake, and improved BW in heat-stressed broilers ( Greene et al., 2020 ). As PFA can have differing effects based on their composition and the majority of the literature focuses on tissue-specific effects, in the present study, we sought to further explore the effect of the PFA-C supplements on the expression profile of circulating inflammasomes, cytokines, and 11``chemokines in broilers exposed to chronic cyclic HS.…”

Section: Introductionmentioning

confidence: 99%

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Research Note: Phytobiotics modulate the expression profile of circulating inflammasome and cyto(chemo)kine in whole blood of broilers exposed to cyclic heat stress

2021

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Heat stress ( HS ) is a critical concern to the poultry industry as it affects both productivity and well-being. Various managerial and nutritional strategies have been proposed to mitigate the negative effects of HS in chickens, with plant-based additives showing promise. Recently, we reported the positive effect of a phytogenic feed additive ( PFA ) on growth performance in HS birds. Owing to the antioxidant nature of these compounds, we sought to further explore the effect of PFA on whole blood circulating chemokines, cytokines, and inflammasomes in HS broilers. Broilers (600 males, 1 d) were randomly assigned to 12 environmental chambers, subjected to 2 environmental conditions (12 h cyclic heat stress, HS, 35°C vs. thermoneutral condition [ TN ], 24°C) and fed 3 diets (control, PFA-C 250 ppm, PFA-C 400 ppm) in a 2 × 3 factorial design. After 21 d of cyclic HS, blood samples were collected for target gene expression analysis. HS upregulated the expression of superoxide dismutase 1 ( SOD1 ) and downregulated glutathione peroxidase-3 ( GPX-3 ), and there was diet × temperature interaction for SOD2, GPX-1, and GPX-3, where gene expression was increased by PFA-C250 during HS but was unchanged for PFA-C400. Plasma total antioxidant capacity ( TAC ) and malondialdehyde ( MDA ) content were increased by HS. Gene expression of interleukin-18 ( IL-18 ) was decreased by HS, without further effect of PFA. HS increased tumor necrosis factor α ( TNFα ), but this effect was mitigated by PFA-C400. C-C motif chemokine ligands 4 and 20 ( CCL4 and CCL20 ) showed a similar pattern to TNFα, with PFA-C400 ameliorating the negative effect of HS. The nucleotide-binding, leucine-rich repeat and pyrin domain containing 3 ( NLRP3 ) inflammasome was decreased by HS and further lowered by PFA-C400, but the nucleotide-binding oligomerization domain, leucine-rich repeat, and CARD domain containing 3 ( NLRC3 ) and nucleotide-binding, leucine-rich repeat containing X1 ( NLRX1 ) inflammasomes were increased by PFA under TN conditions, with no effects of HS. Heat shock proteins ( HSP ) and heat shock factors ( HSF ) were unaffected by PFA or HS. Together these data indicate that gene expression of circulating inflammatory factors are dysregulated during HS, and supplemental dietary PFA may be protective.

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Section: Methodsmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 89%

Section: Results and Dicussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Research Note: Phytobiotics modulate the expression profile of circulating inflammasome and cyto(chemo)kine in whole blood of broilers exposed to cyclic heat stress

2021

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The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs

Bacanlı

2024

Arch Toxicol

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Antibiotics, which have been used for many years to treat infections, also play an important role in food contamination with antibiotic residues. There is also unnecessary use of antibiotics, particularly to increase production efficiency. Non-compliance with withdrawal periods and maximum residue limits (MRLs) for antibiotics used in food-producing animals results in undesirable events, such as allergic reactions, teratogenicity, carcinogenicity, changes in the microbiota and, in particular, antibiotic resistance. Therefore, it may be useful to avoid unnecessary use of antibiotics, to limit the use of antibiotics and to turn to alternatives that can be used instead of antibiotics. The aim of this review is to provide information on the undesirable effects of antibiotic residues in food-producing organisms and in the environment, their determination, and the precautions that can be taken.

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Constant and cyclic chronic heat stress models differentially influence growth performance, carcass traits and meat quality of broilers

Teyssier

Preynat²,

Cozannet³

et al. 2022

Poultry Science

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Protective effects of the phytogenic feed additive “comfort” on growth performance via modulation of hypothalamic feeding- and drinking-related neuropeptides in cyclic heat-stressed broilers

Cited by 18 publications

References 72 publications

Research Note: Phytobiotics modulate the expression profile of circulating inflammasome and cyto(chemo)kine in whole blood of broilers exposed to cyclic heat stress

Research Note: Phytobiotics modulate the expression profile of circulating inflammasome and cyto(chemo)kine in whole blood of broilers exposed to cyclic heat stress

The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs

Constant and cyclic chronic heat stress models differentially influence growth performance, carcass traits and meat quality of broilers

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